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COR1-TCELL SIGNED

Analysis of the role for coronin 1-dependent cell density signalling in T-cell homeostasis

Total Cost €

0

EC-Contrib. €

0

Partnership

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 COR1-TCELL project word cloud

Explore the words cloud of the COR1-TCELL project. It provides you a very rough idea of what is the project "COR1-TCELL" about.

cancer    survival    density    uncharacterized    organs    combine    mass    adoptive    biology    lymphopenic    culture    harnessing    unknown    wd    transfer    dependent    immunotherapy    microbial    suggest    environment    expansion    stimulating    immunity    vivo    prevention    ad    technologies    co    potentiate    requirement    autoimmune    post    reveal    mechanism    ablation    found    receptors    regulated    cell    anti    peripheral    hitherto    antigen    newborns    experiments    rna    sequencing    cytokine    newly    utilising    delineate    knockout    mouse    mechanisms    interleukin    contributes    coronin    recognising    molecular    histocompatibility    repeat    homeostasis    stage    peptides    depends    preliminary    explore    protein    originally    fellowship    recapitulates    vitro    successful    family    hoc    signalling    presenting    single    edge    sensing    inducible    cutting    cells    maintenance    biochemical    mediated    molecules    elucidate    neonatal    loaded    career    spectrometry    disorders    reconstituted    assay    self    underlying    lymphoid   

Project "COR1-TCELL" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT BASEL 

Organization address
address: PETERSPLATZ 1
city: BASEL
postcode: 4051
website: www.unibas.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT BASEL CH (BASEL) coordinator 175˙419.00

Map

 Project objective

Harnessing T-cell homeostasis is important for cancer immunotherapy as well as anti-microbial immunity and the prevention of autoimmune disorders. T-cell homeostasis in peripheral lymphoid organs is known to be regulated through interleukin-7-mediated cytokine signalling and via T-cell receptors recognising self-peptides loaded on major histocompatibility complex. However, recent results suggest a requirement of a third pathway at low T-cell density such as in newborns that depends on the WD repeat protein family member coronin 1, the mechanism of which is unknown. The objective of this proposal is to elucidate the molecular mechanism of coronin 1-dependent sensing of low cell density that contributes to peripheral T-cell homeostasis. In preliminary work, I established a co-culture assay of T cells and antigen presenting cells that recapitulates coronin 1-dependent T-cell survival at low cell density. In addition, I found that adoptive transfer experiments reconstituted the coronin 1-dependent peripheral T-cell expansion in a lymphopenic environment in vivo. To delineate the molecular mechanisms underlying this cell density-dependent signalling mediated by coronin 1, I will combine the originally established in vitro and in vivo assay systems with state-of-the-art single-cell RNA sequencing, in addition to biochemical analysis utilising mass spectrometry. This will identify the signalling pathways and the molecules involved in this density-sensing mechanism. Finally, ad-hoc ablation of coronin 1 using a newly established inducible knockout mouse will reveal the role for coronin 1 in the maintenance of peripheral T cells after successful expansion at post-neonatal stage. The results from this project will define a hitherto uncharacterized density-sensing pathway required for T-cell homeostasis. Furthermore, the fellowship will potentiate my career opportunities as it allows to explore cutting-edge biology and technologies in a highly stimulating research environment.

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The information about "COR1-TCELL" are provided by the European Opendata Portal: CORDIS opendata.

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