Opendata, web and dolomites

COR1-TCELL SIGNED

Analysis of the role for coronin 1-dependent cell density signalling in T-cell homeostasis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 COR1-TCELL project word cloud

Explore the words cloud of the COR1-TCELL project. It provides you a very rough idea of what is the project "COR1-TCELL" about.

organs    cutting    disorders    requirement    wd    neonatal    cell    biochemical    underlying    mass    assay    utilising    protein    maintenance    transfer    prevention    uncharacterized    successful    ablation    vitro    vivo    coronin    delineate    sequencing    expansion    spectrometry    interleukin    cytokine    dependent    mechanism    lymphopenic    histocompatibility    harnessing    career    cells    anti    mediated    preliminary    mechanisms    autoimmune    culture    unknown    technologies    ad    explore    stimulating    cancer    reconstituted    knockout    recapitulates    contributes    single    newly    density    homeostasis    environment    hitherto    elucidate    presenting    post    loaded    repeat    regulated    peptides    self    receptors    molecules    family    survival    microbial    reveal    newborns    sensing    originally    peripheral    depends    molecular    edge    stage    signalling    hoc    potentiate    inducible    experiments    mouse    biology    rna    fellowship    antigen    co    recognising    adoptive    found    immunity    immunotherapy    lymphoid    suggest    combine   

Project "COR1-TCELL" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT BASEL 

Organization address
address: PETERSPLATZ 1
city: BASEL
postcode: 4051
website: www.unibas.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT BASEL CH (BASEL) coordinator 175˙419.00

Map

 Project objective

Harnessing T-cell homeostasis is important for cancer immunotherapy as well as anti-microbial immunity and the prevention of autoimmune disorders. T-cell homeostasis in peripheral lymphoid organs is known to be regulated through interleukin-7-mediated cytokine signalling and via T-cell receptors recognising self-peptides loaded on major histocompatibility complex. However, recent results suggest a requirement of a third pathway at low T-cell density such as in newborns that depends on the WD repeat protein family member coronin 1, the mechanism of which is unknown. The objective of this proposal is to elucidate the molecular mechanism of coronin 1-dependent sensing of low cell density that contributes to peripheral T-cell homeostasis. In preliminary work, I established a co-culture assay of T cells and antigen presenting cells that recapitulates coronin 1-dependent T-cell survival at low cell density. In addition, I found that adoptive transfer experiments reconstituted the coronin 1-dependent peripheral T-cell expansion in a lymphopenic environment in vivo. To delineate the molecular mechanisms underlying this cell density-dependent signalling mediated by coronin 1, I will combine the originally established in vitro and in vivo assay systems with state-of-the-art single-cell RNA sequencing, in addition to biochemical analysis utilising mass spectrometry. This will identify the signalling pathways and the molecules involved in this density-sensing mechanism. Finally, ad-hoc ablation of coronin 1 using a newly established inducible knockout mouse will reveal the role for coronin 1 in the maintenance of peripheral T cells after successful expansion at post-neonatal stage. The results from this project will define a hitherto uncharacterized density-sensing pathway required for T-cell homeostasis. Furthermore, the fellowship will potentiate my career opportunities as it allows to explore cutting-edge biology and technologies in a highly stimulating research environment.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "COR1-TCELL" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "COR1-TCELL" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

PaSION (2018)

A longitudinal assessment of treatment experience, symptoms and potential associations with biomarkers in cancer patients undergoing immune checkpoint inhibitor therapy

Read More  

MegaBiCycle (2019)

The role of megafauna in biogeochemical cycles and greenhouse gas fluxes: implications for climate and ecosystems throughout history

Read More  

MarshFlux (2020)

The effect of future global climate and land-use change on greenhouse gas fluxes and microbial processes in salt marshes

Read More