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COR1-TCELL SIGNED

Analysis of the role for coronin 1-dependent cell density signalling in T-cell homeostasis

Total Cost €

0

EC-Contrib. €

0

Partnership

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 COR1-TCELL project word cloud

Explore the words cloud of the COR1-TCELL project. It provides you a very rough idea of what is the project "COR1-TCELL" about.

expansion    histocompatibility    mass    protein    family    dependent    co    self    recapitulates    culture    density    prevention    spectrometry    anti    maintenance    peripheral    single    ablation    rna    hoc    stimulating    career    potentiate    autoimmune    mechanism    technologies    inducible    recognising    cells    edge    immunotherapy    harnessing    immunity    cutting    homeostasis    experiments    vivo    regulated    newly    sensing    transfer    cell    interleukin    signalling    mechanisms    presenting    environment    knockout    found    assay    biochemical    suggest    reveal    newborns    receptors    reconstituted    hitherto    underlying    wd    preliminary    peptides    cancer    vitro    organs    fellowship    neonatal    molecular    uncharacterized    successful    repeat    originally    contributes    utilising    unknown    lymphopenic    delineate    mediated    depends    explore    coronin    requirement    disorders    antigen    lymphoid    sequencing    mouse    biology    post    adoptive    elucidate    microbial    survival    combine    molecules    loaded    stage    cytokine    ad   

Project "COR1-TCELL" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT BASEL 

Organization address
address: PETERSPLATZ 1
city: BASEL
postcode: 4051
website: www.unibas.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT BASEL CH (BASEL) coordinator 175˙419.00

Map

 Project objective

Harnessing T-cell homeostasis is important for cancer immunotherapy as well as anti-microbial immunity and the prevention of autoimmune disorders. T-cell homeostasis in peripheral lymphoid organs is known to be regulated through interleukin-7-mediated cytokine signalling and via T-cell receptors recognising self-peptides loaded on major histocompatibility complex. However, recent results suggest a requirement of a third pathway at low T-cell density such as in newborns that depends on the WD repeat protein family member coronin 1, the mechanism of which is unknown. The objective of this proposal is to elucidate the molecular mechanism of coronin 1-dependent sensing of low cell density that contributes to peripheral T-cell homeostasis. In preliminary work, I established a co-culture assay of T cells and antigen presenting cells that recapitulates coronin 1-dependent T-cell survival at low cell density. In addition, I found that adoptive transfer experiments reconstituted the coronin 1-dependent peripheral T-cell expansion in a lymphopenic environment in vivo. To delineate the molecular mechanisms underlying this cell density-dependent signalling mediated by coronin 1, I will combine the originally established in vitro and in vivo assay systems with state-of-the-art single-cell RNA sequencing, in addition to biochemical analysis utilising mass spectrometry. This will identify the signalling pathways and the molecules involved in this density-sensing mechanism. Finally, ad-hoc ablation of coronin 1 using a newly established inducible knockout mouse will reveal the role for coronin 1 in the maintenance of peripheral T cells after successful expansion at post-neonatal stage. The results from this project will define a hitherto uncharacterized density-sensing pathway required for T-cell homeostasis. Furthermore, the fellowship will potentiate my career opportunities as it allows to explore cutting-edge biology and technologies in a highly stimulating research environment.

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The information about "COR1-TCELL" are provided by the European Opendata Portal: CORDIS opendata.

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