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SiMBiT SIGNED

Single molecule bio-electronic smart system array for clinical testing

Total Cost €

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EC-Contrib. €

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Partnership

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Project "SiMBiT" data sheet

The following table provides information about the project.

Coordinator
CONSORZIO INTERUNIVERSITARIO PERLO SVILUPPO DEI SISTEMI A GRANDE INTERFASE 

Organization address
address: VIA DELLA LASTRUCCIA 3
city: FIRENZE
postcode: 50019
website: www.csgi.unifi.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 3˙020˙638 €
 EC max contribution 3˙020˙638 € (100%)
 Programme 1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT))
 Code Call H2020-ICT-2018-2
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSORZIO INTERUNIVERSITARIO PERLO SVILUPPO DEI SISTEMI A GRANDE INTERFASE IT (FIRENZE) coordinator 390˙750.00
2    HEINRICH-HEINE-UNIVERSITAET DUESSELDORF DE (DUSSELDORF) participant 415˙765.00
3    UNIVERSITA DEGLI STUDI DI BRESCIA IT (BRESCIA) participant 391˙221.00
4    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) participant 389˙998.00
5    FLEXENABLE LIMITED UK (CAMBRIDGE) participant 355˙403.00
6    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) participant 352˙500.00
7    ABO AKADEMI FI (ABO) participant 350˙000.00
8    MASMEC SPA IT (MODUGNO) participant 262˙500.00
9    EFFICIENT INNOVATION SAS FR (CASTELNAU LE LEZ) participant 112˙500.00

Map

 Project objective

Digitizing biomarkers analysis by quantifying them at the single-molecule level is the new frontier for advancing the science of precision health. The SiMBiT project will develop a bio-electronic smart system leveraging on an existing lab-based proof-of-concept that can perform single-molecule detection of both proteins and DNA bio-markers. Specifically, the SiMBiT activities will develop the lab-based device into a cost-effective portable multiplexing array prototype that integrates, with a modular approach, novel materials and standard components/interfaces. The SiMBiT platform exhibits enhanced sensing capabilities: specificity towards both genomic and protein markers along with single-molecule detection limits and time-to-results within two hours. This makes the SiMBiT prototype the world best performing bio-electronic sensing system ever. SiMBiT will reach these ambitious goals with a multidisciplinary research effort involving device-physicists, analytical-chemists, bio-chemists, clinicians, electronic- and system-engineers. The platform is also single-use and cost-effective and can work in low-resource settings. The SiMBiT field-effect sensing system will be fabricated by means of future mass-manufacturable, large-area compatible, scalable techniques such as printing and other direct-writing processes. 3D printing of a module is also foreseen. The SiMBiT prototype will demonstrate, for first time, a matrix of up to 96 bio-electronic sensors and a Si IC chip for the processing of all data coming from the matrix, multiplexing single-molecule detection. As the Si IC pins are limited the chip area is reduced and its cost minimized, enabling a single-use assay plate. SiMBiT will apply the multiplexing single molecule technology to the early detection of human pancreatic neoplasms in a well-defined clinical context, performing simultaneous analysis of genomic and protein markers with a minimal sample volume, reduced costs and reduced time-to-results.

 Publications

year authors and title journal last update
List of publications.
2019 Eleonora Macchia, Kyriaki Manoli, Brigitte Holzer, Cinzia Di Franco, Rosaria A. Picca, Nicola Cioffi, Gaetano Scamarcio, Gerardo Palazzo, Luisa Torsi
Selective single-molecule analytical detection of C-reactive protein in saliva with an organic transistor
published pages: 4899-4908, ISSN: 1618-2642, DOI: 10.1007/s00216-019-01778-2
Analytical and Bioanalytical Chemistry 411/19 2020-03-05
2019 Rosaria Anna Picca, Kyriaki Manoli, Eleonora Macchia, Angelo Tricase, Cinzia Di Franco, Gaetano Scamarcio, Nicola Cioffi, Luisa Torsi
A Study on the Stability of Water-Gated Organic Field-Effect-Transistors Based on a Commercial p-Type Polymer
published pages: , ISSN: 2296-2646, DOI: 10.3389/fchem.2019.00667
Frontiers in Chemistry 7 2020-03-05
2018 Eleonora Macchia, Amber Tiwari, Kyriaki Manoli, Brigitte Holzer, Nicoletta Ditaranto, Rosaria Anna Picca, Nicola Cioffi, Cinzia Di Franco, Gaetano Scamarcio, Gerardo Palazzo, Luisa Torsi
Label-Free and Selective Single-Molecule Bioelectronic Sensing with a Millimeter-Wide Self-Assembled Monolayer of Anti-Immunoglobulins
published pages: 6476-6483, ISSN: 0897-4756, DOI: 10.1021/acs.chemmater.8b04414
Chemistry of Materials 31/17 2020-03-05
2020 Eleonora Macchia, Lucia Sarcina, Rosaria Anna Picca, Kyriaki Manoli, Cinzia Di Franco, Gaetano Scamarcio, Luisa Torsi
Ultra-low HIV-1 p24 detection limits with a bioelectronic sensor
published pages: 811-818, ISSN: 1618-2642, DOI: 10.1007/s00216-019-02319-7
Analytical and Bioanalytical Chemistry 412/4 2020-03-05
2019 Rosaria Anna Picca, Kyriaki Manoli, Eleonora Macchia, Lucia Sarcina, Cinzia Di Franco, Nicola Cioffi, Davide Blasi, Ronald Österbacka, Fabrizio Torricelli, Gaetano Scamarcio, Luisa Torsi
Ultimately Sensitive Organic Bioelectronic Transistor Sensors by Materials and Device Structures\' Design
published pages: 1904513, ISSN: 1616-301X, DOI: 10.1002/adfm.201904513
Advanced Functional Materials 2020-03-05
2019 K. Ebner, C. Driescher, W. Goering, L. Haeberle, V. Keitel, D. Haeussinger, I. Esposito.
Case report: NGS of cell-free DNA from blood and bile as a follow-up strategy in a patient with metastatic pancreatic adenocarcinoma
published pages: S235, ISSN: , DOI:
Virchows Archiv 2020-03-05
2019 C. Driescher, K. Ebner, W. Goering, L. Haeberle, V. Keitel, D. Haeussinger, I. Esposito
Exploitation of cfDNA extracted from bile as liquid biopsy source in pancreatobiliary cancers
published pages: S62, ISSN: , DOI:
Virchows Archiv 2020-03-05

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