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Targeting pathological synaptic pruning by microglia in neurodegeneration

Total Cost €


EC-Contrib. €






 REMIND project word cloud

Explore the words cloud of the REMIND project. It provides you a very rough idea of what is the project "REMIND" about.

underlying    mouse    neurodegeneration    disease    introducing    cognitive    remodelling    responsible    impairment    generating    dysfunctional    shaper    majority    signature    encoded    transcriptomics    metabolic    little    causal    generate    models    genetically    brain    microglia    combining    characterisation    resolution    synapses    implicate    association    assays    diseases    pathogenesis    extensive    molecular    pathological    neurodegenerative    disorders    mediated    risk    reveal    drugs    techniques    link    genome    genes    goals    variants    pathology    proteomics    alone    synapse    asses    microscopy    players    vivo    nanobodies    cutting    ex    expressed    microglial    function    remind    labelling    crispr    editing    cas9    prunining    indicates    phagocytosis    validating    mechanisms    poorly    mediate    pruning    multidisciplinary    vitro    cells    synaptic    summary    combination    degradation    advantage    super    genetic    literature    suggests    intense    edge    correlate    strategies   

Project "REMIND" data sheet

The following table provides information about the project.


Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
postcode: 1015

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙499˙991 €
 EC max contribution 1˙499˙991 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 1˙499˙991.00


 Project objective

Synapse loss is the major correlate of cognitive impairment in many neurodegenerative diseases. Recent literature suggests that microglia, which mediate synaptic pruning during brain development, can be responsible for synapse loss in neurodegeneration. Although the underlying mechanisms are poorly understood, growing evidence indicates that dysfunctional microglia affect synapses number and function in pathology. Genome-wide association studies reveal that the majority of risk genes associated with neurodegenerative disorders are highly expressed in microglia. While such studies clearly implicate these cells in the pathogenesis of the disease, little is known about the causal mechanisms that link microglial risk variants to loss of synapses. We will identify the molecular mechanisms involved in microglia-mediated synapse loss. We will also generate novel in vitro and ex vivo models of ‘risk microglia’, by introducing genetic variants associated with cognitive impairment –alone or in combination- specifically in microglia, taking advantage of CRISPR/ Cas9 genome editing techniques. These goals will be achieved by combining cutting-edge transcriptomics and proteomics with mouse models of intense synaptic remodelling, to reveal the unique molecular signature of ‘shaper microglia’. A multidisciplinary approach will allow the extensive characterisation of risk models, by combining metabolic analysis, synaptic phagocytosis and degradation assays, with super-resolution microscopy, and novel genetically encoded labelling methods. With the knowledge generated here, we aim at developing and validating in vivo novel drugs- and nanobodies-based approaches for effective targeting of pathological pruning. In summary, REMIND will focus on: 1) Identifying molecular players in microglial-mediated synapse loss 2) Generating ‘risk microglia’ models, to asses the role of genetic variants associated with neurodegeneration 3) Developing novel strategies for targeting prunining

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The information about "REMIND" are provided by the European Opendata Portal: CORDIS opendata.

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