Opendata, web and dolomites

REMIND SIGNED

Targeting pathological synaptic pruning by microglia in neurodegeneration

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 REMIND project word cloud

Explore the words cloud of the REMIND project. It provides you a very rough idea of what is the project "REMIND" about.

implicate    molecular    pathogenesis    synaptic    risk    introducing    disease    literature    genome    vivo    combining    remodelling    nanobodies    resolution    labelling    synapses    disorders    drugs    extensive    genetic    suggests    expressed    cells    proteomics    remind    strategies    multidisciplinary    indicates    combination    goals    mechanisms    microglial    genetically    shaper    degradation    cognitive    validating    characterisation    prunining    crispr    vitro    mouse    genes    responsible    editing    brain    microglia    advantage    link    pathological    pruning    poorly    association    signature    synapse    diseases    transcriptomics    super    neurodegenerative    assays    ex    dysfunctional    intense    encoded    mediate    generating    alone    little    microscopy    models    neurodegeneration    generate    underlying    mediated    causal    reveal    players    techniques    impairment    cas9    edge    pathology    cutting    majority    summary    function    metabolic    asses    correlate    variants    phagocytosis   

Project "REMIND" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LAUSANNE 

Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
city: LAUSANNE
postcode: 1015
website: www.unil.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙499˙991 €
 EC max contribution 1˙499˙991 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 1˙499˙991.00

Map

 Project objective

Synapse loss is the major correlate of cognitive impairment in many neurodegenerative diseases. Recent literature suggests that microglia, which mediate synaptic pruning during brain development, can be responsible for synapse loss in neurodegeneration. Although the underlying mechanisms are poorly understood, growing evidence indicates that dysfunctional microglia affect synapses number and function in pathology. Genome-wide association studies reveal that the majority of risk genes associated with neurodegenerative disorders are highly expressed in microglia. While such studies clearly implicate these cells in the pathogenesis of the disease, little is known about the causal mechanisms that link microglial risk variants to loss of synapses. We will identify the molecular mechanisms involved in microglia-mediated synapse loss. We will also generate novel in vitro and ex vivo models of ‘risk microglia’, by introducing genetic variants associated with cognitive impairment –alone or in combination- specifically in microglia, taking advantage of CRISPR/ Cas9 genome editing techniques. These goals will be achieved by combining cutting-edge transcriptomics and proteomics with mouse models of intense synaptic remodelling, to reveal the unique molecular signature of ‘shaper microglia’. A multidisciplinary approach will allow the extensive characterisation of risk models, by combining metabolic analysis, synaptic phagocytosis and degradation assays, with super-resolution microscopy, and novel genetically encoded labelling methods. With the knowledge generated here, we aim at developing and validating in vivo novel drugs- and nanobodies-based approaches for effective targeting of pathological pruning. In summary, REMIND will focus on: 1) Identifying molecular players in microglial-mediated synapse loss 2) Generating ‘risk microglia’ models, to asses the role of genetic variants associated with neurodegeneration 3) Developing novel strategies for targeting prunining

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "REMIND" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "REMIND" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

PonD (2019)

Particles-on-Demand for Multiscale Fluid Dynamics

Read More  

Aware (2019)

Aiding Antibiotic Development with Deep Analysis of Resistance Evolution

Read More  

ENUF (2019)

Evaluation of Novel Ultra-Fast selective III-V Epitaxy

Read More