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fetISC SIGNED

Characterizing drivers of intestinal tissue maturation in vitro and in vivo

Total Cost €

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EC-Contrib. €

0

Partnership

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 fetISC project word cloud

Explore the words cloud of the fetISC project. It provides you a very rough idea of what is the project "fetISC" about.

differentiation    origin    either    tracing    maturation    cell    intestinal    pluripotent    constitute    regenerative    differentiated    modulation    progression    sources    specified    gene    overexpressed    combine    physiological    initiated    murine    immature    profiling    developmental    tissue    one    medicine    intestines    instrumental    endodermal    stage    clinics    trigger    protocols    transplantation    transcription    structures    generate    direct    mechanisms    hipsc    absence    acquire    mapping    driving    counterpart    fine    impede    vitro    transferability    intestine    epithelium    govern    therapies    expression    disease    iscs    techniques    expressed    adult    laboratory    stem    human    models    neonatal    responsible    purposes    calf    host    serum    suitability    mature    elucidated    secretory    molecular    platform    location    cells    decipher    hypothesize    notably    precise    exposure    isc    differentially    mice    teratoma    lineages    fetal    culture    incubators   

Project "fetISC" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website https://www.bric.ku.dk/Research/jensen_group/
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2018-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 212˙194.00

Map

 Project objective

One of the challenges in regenerative medicine is to generate adult intestinal stem cells (ISCs) from human induced pluripotent stem cells (hiPSC) in vitro in defined conditions. This will be important in order to establish intestinal cell transplantation therapies and a platform for neonatal disease modelling. These issues constitute the main goal of the proposal. The current protocols to direct intestinal differentiation from hiPSC impede their suitability for human transplantation purposes either because they require mice as tissue culture incubators (teratoma formation), long exposure to calf serum, or generate cells with fetal properties. The immature fetal intestine is distinct from its mature counterpart most notably by its absence of differentiated secretory lineages. Moreover the precise location and developmental stage from which ISCs are specified in fetal intestine as well as the mechanisms that govern the progression towards an adult epithelium remain to be elucidated. In order to generate adult ISCs from pluripotent sources it is instrumental to decipher the molecular mechanisms driving ISC maturation under physiological conditions. The project will be initiated with the fine mapping of ISC origin in the fetal epithelium using cell tracing techniques. Then I will characterize how fetal ISCs acquire adult properties at the molecular level. In the host laboratory we hypothesize that differentially expressed transcription factors are responsible for the unique characteristics of fetal and adult ISCs. Recently, using gene expression profiling comparing fetal and adult intestinal cells I have identified specific endodermal transcription factors overexpressed in the immature structures. I expect through the modulation of such factors to trigger the intestinal maturation. To ensure the transferability of the results into clinics I will combine studies with murine models and cells from human fetal and adult intestines.

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The information about "FETISC" are provided by the European Opendata Portal: CORDIS opendata.

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