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Characterizing drivers of intestinal tissue maturation in vitro and in vivo

Total Cost €


EC-Contrib. €






 fetISC project word cloud

Explore the words cloud of the fetISC project. It provides you a very rough idea of what is the project "fetISC" about.

responsible    models    cells    teratoma    structures    profiling    physiological    specified    location    regenerative    transplantation    stem    intestine    lineages    gene    clinics    developmental    epithelium    generate    precise    overexpressed    driving    adult    constitute    progression    tracing    endodermal    one    secretory    impede    mapping    differentiation    mice    hipsc    elucidated    intestinal    counterpart    culture    isc    human    protocols    pluripotent    mature    cell    exposure    modulation    origin    laboratory    differentially    trigger    fine    maturation    hypothesize    serum    neonatal    initiated    acquire    calf    notably    either    disease    sources    vitro    direct    tissue    transcription    govern    transferability    stage    expression    medicine    differentiated    platform    immature    expressed    molecular    host    purposes    murine    therapies    suitability    intestines    fetal    combine    decipher    incubators    iscs    techniques    instrumental    absence    mechanisms   

Project "fetISC" data sheet

The following table provides information about the project.


Organization address
address: NORREGADE 10
postcode: 1165

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2018-01-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 212˙194.00


 Project objective

One of the challenges in regenerative medicine is to generate adult intestinal stem cells (ISCs) from human induced pluripotent stem cells (hiPSC) in vitro in defined conditions. This will be important in order to establish intestinal cell transplantation therapies and a platform for neonatal disease modelling. These issues constitute the main goal of the proposal. The current protocols to direct intestinal differentiation from hiPSC impede their suitability for human transplantation purposes either because they require mice as tissue culture incubators (teratoma formation), long exposure to calf serum, or generate cells with fetal properties. The immature fetal intestine is distinct from its mature counterpart most notably by its absence of differentiated secretory lineages. Moreover the precise location and developmental stage from which ISCs are specified in fetal intestine as well as the mechanisms that govern the progression towards an adult epithelium remain to be elucidated. In order to generate adult ISCs from pluripotent sources it is instrumental to decipher the molecular mechanisms driving ISC maturation under physiological conditions. The project will be initiated with the fine mapping of ISC origin in the fetal epithelium using cell tracing techniques. Then I will characterize how fetal ISCs acquire adult properties at the molecular level. In the host laboratory we hypothesize that differentially expressed transcription factors are responsible for the unique characteristics of fetal and adult ISCs. Recently, using gene expression profiling comparing fetal and adult intestinal cells I have identified specific endodermal transcription factors overexpressed in the immature structures. I expect through the modulation of such factors to trigger the intestinal maturation. To ensure the transferability of the results into clinics I will combine studies with murine models and cells from human fetal and adult intestines.

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The information about "FETISC" are provided by the European Opendata Portal: CORDIS opendata.

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