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C-MORPH SIGNED

Noninvasive cell specific morphometry in neuroinflammation and degeneration

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 C-MORPH project word cloud

Explore the words cloud of the C-MORPH project. It provides you a very rough idea of what is the project "C-MORPH" about.

underlying    imaging    trajectories    ultra    mechanistic    personalized    experimental    tools    sensitive    outs    padws    brain    once    morph    treatment    translational    hardware    framework    regional    validate    degeneration    medicine    magnetic    therapeutic    averaged    caused    healthy    microstructure    probes    central    techniques    mr    realize    resonance    tuned    harvest    simplified    inter    decisions    spectrally    unbiased    prerequisite    markers    limited    microstructural    disentangling    diffusion    derive    size    human    validated    tool    fingerprints    applicable    neuroimaging    hampers    push    links    weighted    specificity    histological    precision    validation    methodology    stgt    neurodegeneration    synergy    marker    tissue    diseased    cell    isolate    structural    diseases    inflammation    intact    shape    tackle    individual    clinically    variation    frontiers    vivo    line    spectroscopic    gradient    guiding    constitute    independent    structure    morphometry    determines    function    disease    spectroscopy    innovations    powder    read    harness   

Project "C-MORPH" data sheet

The following table provides information about the project.

Coordinator
REGION HOVEDSTADEN 

Organization address
address: KONGENS VAENGE 2
city: HILLEROD
postcode: 3400
website: www.regionh.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙498˙811 €
 EC max contribution 1˙498˙811 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2023-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    REGION HOVEDSTADEN DK (HILLEROD) coordinator 1˙498˙811.00

Map

 Project objective

Brain structure determines function. Disentangling regional microstructural properties and understanding how these properties constitute brain function is a central goal of neuroimaging of the human brain and a key prerequisite for a mechanistic understanding of brain diseases and their treatment. Using magnetic resonance (MR) imaging, previous research has established links between regional brain microstructure and inter-individual variation in brain function, but this line of research has been limited by the non-specificity of MR-derived markers. This hampers the application of MR imaging as a tool to identify specific fingerprints of the underlying disease process. Exploiting state-of-the-art ultra-high field MR imaging techniques, I have recently developed two independent spectroscopic MR methods that have the potential to tackle this challenge: Powder averaged diffusion weighted spectroscopy (PADWS) can provide an unbiased marker for cell specific structural degeneration, and Spectrally tuned gradient trajectories (STGT) can isolate cell shape and size. In this project, I will harness these innovations for MR-based precision medicine. I will advance PADWS and STGT methodology on state-of-the-art MR hardware and harvest the synergy of these methods to realize Cell-specific in-vivo MORPHOMETRY (C-MORPH) of the intact human brain. I will establish novel MR read-outs and analyses to derive cell-type specific tissue properties in the healthy and diseased brain and validate them with the help of a strong translational experimental framework, including histological validation. Once validated, the experimental methods and analyses will be simplified and adapted to provide clinically applicable tools. This will push the frontiers of MR-based personalized medicine, guiding therapeutic decisions by providing sensitive probes of cell-specific microstructural changes caused by inflammation, neurodegeneration or treatment response.

 Publications

year authors and title journal last update
List of publications.
2019 H. Lundell, M. Nilsson, T. B. Dyrby, G. J. M. Parker, P. L. Hubbard Cristinacce, F.-L. Zhou, D. Topgaard, S. Lasič
Multidimensional diffusion MRI with spectrally modulated gradients reveals unprecedented microstructural detail
published pages: 1-12, ISSN: 2045-2322, DOI: 10.1038/s41598-019-45235-7
Scientific Reports 9/1 2019-11-25

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