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EvoLucin SIGNED

400 Million Years of Symbiosis: Host-microbe interactions in marine lucinid clams from past to present

Total Cost €

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EC-Contrib. €

0

Partnership

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 EvoLucin project word cloud

Explore the words cloud of the EvoLucin project. It provides you a very rough idea of what is the project "EvoLucin" about.

microbes    basis    outstanding    bacterial    infection    history    molecular    fundamentally    hypothesize    combine    symbiotic    evolutionary    symbionts    lucinid    select    organ    ideal    environment    clams    insights    lifetimes    drive    clam    intracellular    alter    bacteria    location    function    microbe    free    animal    families    host    symbiont    lived    recognition    communication    distant    infected    virtually    gill    experimentally    diversity    staggering    lab    species    maintenance    limited    juveniles    exchange    400    few    transforming    assumptions    nature    unmatched    raised    chemosynthetic    immense    found    ancient    edge    understand    innate    tools    marine    million    parts    immune    specificity    perpetuation    symbiosis    interactions    experimental    considering    association    overarching    underlying    cutting    microbial    mechanisms    discovering    trillions    earth    exclusive    animals    emergence    encoded    biology    housed    proteins    lucinidae    oceans    acquisition    evolution    cells    health    interaction   

Project "EvoLucin" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT WIEN 

Organization address
address: UNIVERSITATSRING 1
city: WIEN
postcode: 1010
website: www.univie.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 1˙499˙561 €
 EC max contribution 1˙499˙561 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT WIEN AT (WIEN) coordinator 1˙499˙561.00

Map

 Project objective

The widespread recognition that interactions with microbes drive animal health, development and evolution is transforming biology, but we so far understand the underlying mechanisms in very few systems. Considering that virtually every animal on Earth evolved with and among the microbes in its environment, there is still immense potential for discovering fundamentally new mechanisms of interaction among the staggering diversity of animals and their microbial symbionts in nature. The ancient and exclusive association between marine lucinid clams and chemosynthetic symbiotic bacteria is ideal for investigating these interactions. Lucinidae is one of the most widespread and species-rich animal families in the oceans today, and has lived in symbiosis for more than 400 million years. The clam’s outstanding ability to select one specific symbiont from the trillions of bacteria in its environment challenges widely held assumptions about the function and specificity of the innate immune system. Symbiont-free juveniles can be raised in the lab, and experimentally infected, allowing unmatched insights into the early development of this symbiosis. Although the symbiont infection is specific to gill cells, symbiont-encoded proteins can be found in distant parts of the animal that are symbiont-free. I will combine cutting-edge molecular tools and experimental infection to better understand three key aspects of host-microbe interactions in these clams: 1) Acquisition and selection of microbes during animal development, 2) Maintenance along animal lifetimes through molecular communication and exchange, and 3) Emergence and perpetuation over evolution. I hypothesize that intracellular bacterial symbionts fundamentally alter host biology, and these effects are not limited to the location where symbionts are housed, but can affect distant organ systems. My overarching goal is to understand the molecular basis for these effects, and their evolutionary history.

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The information about "EVOLUCIN" are provided by the European Opendata Portal: CORDIS opendata.

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