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BUBBLE CURE SIGNED

Targeted microbubble vibrations to accurately diagnose and treat cardiac device-related bacterial biofilm infections

Total Cost €

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EC-Contrib. €

0

Partnership

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 BUBBLE CURE project word cloud

Explore the words cloud of the BUBBLE CURE project. It provides you a very rough idea of what is the project "BUBBLE CURE" about.

cardiac    link    cells    ing       pose    mortality    sensitivity    icd    lacks    tissue    yearly    vibrations    vitro    combining    drug    lvad    cell    vibration    valve    single    life    agents    bubble    healthcare    primary    treatment    burden    aging    layer    infections    contrast    device    accurately    60    micron    worldwide    29    size    scientific    first    prosthetic    advancing    infection    accurate    microbubbles    diagnostic    agent    million    patterns    induce    eradicate    tmb    theranostic    imaging    cardiology    population    rate    ultrasound    diagnosis    vibrating    modeling    showing    time    50    bacteria    detect    signal    wall    thereby    specificity    pacemaker    direction    biofilm    vascular    detection    team    due    implanted    crt    interaction    caused    healthy    multidisciplinary    vessel    bacterial    kill    threatening    cure    technique    exceptional    impossible    3d    modality    microbiology    therapy   

Project "BUBBLE CURE" data sheet

The following table provides information about the project.

Coordinator
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM 

Organization address
address: DR MOLEWATERPLEIN 40
city: ROTTERDAM
postcode: 3015 GD
website: www.erasmusmc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙878˙000 €
 EC max contribution 1˙878˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) coordinator 1˙878˙000.00

Map

 Project objective

Due to an aging population, increasingly more cardiac devices are implanted (pacemaker/ICD/CRT/ prosthetic valve/LVAD; worldwide ~2 million yearly). Life-threatening bacterial infections (1-60% infection and 29-50% mortality rate) associated with these devices are a major healthcare burden and pose scientific challenges. Ultrasound imaging is currently the primary diagnostic modality. However, it lacks specificity and sensitivity because the signal from the bacteria is similar to the signal of healthy tissue or the cardiac device, thus making accurate diagnosis impossible. Recent developments in targeted ultrasound contrast agents (i.e. targeted microbubbles (tMB), 1-8 micron in size) allow ultrasound imaging of a specific tMB vibration signal resulting in exceptional sensitivity and specificity. Advancing tMB imaging to detect bacterial infections is needed to solve the challenges caused by the complex ultrasound field from these devices. I was the first to show that vibrating tMB induce vascular drug uptake, thereby showing the potential of tMB as a theranostic agent by combining imaging with drug delivery. Recently, my team and I were also the first to demonstrate which tMB vibrations kill vessel wall cells in vitro by developing analysis methods that link tMB vibrations to drug uptake patterns on a single cell layer. As this is the first time this technique will be applied to 3D bacterial biofilm infections on cardiac devices, I will go beyond the state-of-the-art in tMB-tissue interaction technology by developing novel detection, analysis, and modeling methods to accurately determine which tMB vibrations eradicate bacterial biofilm infections on devices. The Bubble Cure project will result in a novel multidisciplinary technology that allows accurate diagnosis and treatment of cardiac device-related bacterial biofilm infections, thereby creating a whole new direction of tMB ultrasound imaging and therapy in the scientific field of cardiology and microbiology.

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The information about "BUBBLE CURE" are provided by the European Opendata Portal: CORDIS opendata.

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