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BUBBLE CURE SIGNED

Targeted microbubble vibrations to accurately diagnose and treat cardiac device-related bacterial biofilm infections

Total Cost €

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EC-Contrib. €

0

Partnership

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 BUBBLE CURE project word cloud

Explore the words cloud of the BUBBLE CURE project. It provides you a very rough idea of what is the project "BUBBLE CURE" about.

lvad    modeling    microbiology    single    eradicate    diagnostic    29    layer    advancing    micron    ultrasound    detection    yearly    device    diagnosis    agents    direction    patterns    icd    theranostic    size    tissue    imaging    technique    cell    lacks    ing    cells    valve    agent    vitro    cardiology    caused    prosthetic    bacterial    multidisciplinary    combining    infections    vessel    scientific    mortality    therapy    burden    modality    tmb    signal    50    60    biofilm    cure    infection    due    vibrating    contrast    implanted    worldwide    interaction    vascular    exceptional    pose    accurate    wall    aging    population    treatment    first    drug    vibration       threatening    vibrations    cardiac    rate    healthcare    thereby    time    3d    impossible    million    primary    bubble    detect    kill    pacemaker    accurately    sensitivity    link    specificity    life    healthy    team    showing    microbubbles    bacteria    crt    induce   

Project "BUBBLE CURE" data sheet

The following table provides information about the project.

Coordinator
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM 

Organization address
address: DR MOLEWATERPLEIN 40
city: ROTTERDAM
postcode: 3015 GD
website: www.erasmusmc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙878˙000 €
 EC max contribution 1˙878˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) coordinator 1˙878˙000.00

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 Project objective

Due to an aging population, increasingly more cardiac devices are implanted (pacemaker/ICD/CRT/ prosthetic valve/LVAD; worldwide ~2 million yearly). Life-threatening bacterial infections (1-60% infection and 29-50% mortality rate) associated with these devices are a major healthcare burden and pose scientific challenges. Ultrasound imaging is currently the primary diagnostic modality. However, it lacks specificity and sensitivity because the signal from the bacteria is similar to the signal of healthy tissue or the cardiac device, thus making accurate diagnosis impossible. Recent developments in targeted ultrasound contrast agents (i.e. targeted microbubbles (tMB), 1-8 micron in size) allow ultrasound imaging of a specific tMB vibration signal resulting in exceptional sensitivity and specificity. Advancing tMB imaging to detect bacterial infections is needed to solve the challenges caused by the complex ultrasound field from these devices. I was the first to show that vibrating tMB induce vascular drug uptake, thereby showing the potential of tMB as a theranostic agent by combining imaging with drug delivery. Recently, my team and I were also the first to demonstrate which tMB vibrations kill vessel wall cells in vitro by developing analysis methods that link tMB vibrations to drug uptake patterns on a single cell layer. As this is the first time this technique will be applied to 3D bacterial biofilm infections on cardiac devices, I will go beyond the state-of-the-art in tMB-tissue interaction technology by developing novel detection, analysis, and modeling methods to accurately determine which tMB vibrations eradicate bacterial biofilm infections on devices. The Bubble Cure project will result in a novel multidisciplinary technology that allows accurate diagnosis and treatment of cardiac device-related bacterial biofilm infections, thereby creating a whole new direction of tMB ultrasound imaging and therapy in the scientific field of cardiology and microbiology.

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The information about "BUBBLE CURE" are provided by the European Opendata Portal: CORDIS opendata.

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