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SynBio4Flav SIGNED

Synthetic microbial consortia-based platform for flavonoids production using synthetic biology

Total Cost €

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EC-Contrib. €

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Partnership

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 SynBio4Flav project word cloud

Explore the words cloud of the SynBio4Flav project. It provides you a very rough idea of what is the project "SynBio4Flav" about.

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Project "SynBio4Flav" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 7˙371˙051 €
 EC max contribution 7˙371˙051 € (100%)
 Programme 1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
 Code Call H2020-NMBP-BIO-2018-two-stage
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 1˙704˙071.00
2    CHALMERS TEKNISKA HOEGSKOLA AB SE (GOETEBORG) participant 1˙206˙128.00
3    UNIVERSITAET GREIFSWALD DE (GREIFSWALD) participant 706˙250.00
4    UNIVERSIDAD DE OVIEDO ES (OVIEDO) participant 628˙985.00
5    BIOPOLIS SL ES (PATERNA VALENCIA) participant 614˙752.00
6    EXPLORA SRL IT (ROMA) participant 566˙666.00
7    DEUTSCHES INSTITUT FUER ERNAEHRUNGSFORSCHUNG POTSDAM REHBRUECKE DE (NUTHETAL) participant 552˙987.00
8    UNIWERSYTET PRZYRODNICZY WE WROCLAWIU PL (WROCLAW) participant 528˙110.00
9    LIQUIFER SYSTEMS GROUP GMBH AT (Vienna) participant 324˙378.00
10    EXTRASYNTHESE SAS FR (GENAY) participant 270˙208.00
11    SYMRISE AG DE (HOLZMINDEN) participant 268˙512.00

Map

 Project objective

This Project pursues the implementation a standardized pipeline for surrogate production of plant flavonoids in synthetic microbial consortia (SMCs) by means of standardization and systems-guided assembly of highly complex biological devices. Flavonoids are the more abundant and consumed group of phytonutrients, used in numerous applications including functional food & beverages, dietary supplements, cosmetics, and pharmaceuticals. Despite its growing demand, flavonoids production remains elusive to chemical synthesis and biotech-based approaches, thus current flavonoid market is constrained to the scarce plant-based sources. These compounds are synthetized in nature through complex pathways involving an intense chemicals trafficking through plant compartments. By facilitating component troubleshooting and re-usability—instead of optimizing a single whole-cell biocatalyst— SynBio4Flav will recreate such non-homogeneous scenario by breaking-down specific portions of the complexes and highly regulated biochemical routes between different microbial species, each of them genetically programmed to deliver an optimal output of the corresponding biosynthetic step(s) i.e. through a distributed catalysis engineered in a defined SMC. Enabling such novel approach, SynBio4Flav will push the existing boundaries of the synthetic biology by acting along the whole Synthetic Biology hierarchy abstraction, and remarkably, in those with high complexity level e.g. cell systems and microbial communities. By creating libraries of optimized cell systems programmed to deliver an optimal output, and novel synthetic biology tools for cell systems assembling into 3D SMCs, SysBio4Flav will reach a TRL5 in production of natural and new-to-nature glycosylated flavonoids. The durable output of SynBio4Flav will be a standardized platform containing hundreds of optimal cell systems for exploring the full combinatorial space of flavonoids biosynthesis, including thousands of new-to-nature analogues.

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The information about "SYNBIO4FLAV" are provided by the European Opendata Portal: CORDIS opendata.

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