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EpiTune SIGNED

Epigenetic fine-tuning of T cells for improved adoptive cell therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EpiTune project word cloud

Explore the words cloud of the EpiTune project. It provides you a very rough idea of what is the project "EpiTune" about.

cas9    tackle    fitness    angle    organ    clinical    expansion    patient    transplantation    cell    profound    manipulations    plasticity    players    differentiation    transfusion    opposite    effect    immune    desired    senescence    harbor    settings    encounter    immunosuppressive    pro    functional    equip    therapy    tuning    prospect    reveal    immunity    efficiency    stable    modifications    obstacles    dna    sensitive    genomic    combating    lymphocytes    acquisition    fine    strategies    innovative    successful    methylation    environment    stability    epi    mechanism    directed    survival    mechanisms    basic    imprint    safe    cancer    adoptive    crispr    epigenetically    hampered    switch    cellular    infections    fighting    imprinting    vitro    therapeutic    editing    utilizing    inflammatory    essentially    shot    auto    cells    molecular    reactivity    infusion    safety    developmental    mediated    epigenome    manipulation    epigenetic    undesired    goals    structure    chronic    reconstitution    limits   

Project "EpiTune" data sheet

The following table provides information about the project.

Coordinator
CHARITE - UNIVERSITAETSMEDIZIN BERLIN 

Organization address
address: Chariteplatz 1
city: BERLIN
postcode: 10117
website: www.charite.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙489˙725 €
 EC max contribution 1˙489˙725 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) coordinator 1˙489˙725.00

Map

 Project objective

'Adoptive T cell therapy is a promising approach in various clinical settings, from target-specific immune reconstitution fighting cancer and chronic infections to combating undesired immune reactivity during auto-immunity and after organ transplantation. However, its clinical application is currently hampered by: 1) the acquisition of senescence during the required in vitro expansion phase of T cells which limits their survival and fitness after infusion into the patient, and 2) the functional plasticity of T cells, which is sensitive to the inflammatory environment they encounter after transfusion and which might result in a functional switch from the desired effect (e.g. immunosuppressive) to the opposite one (pro-inflammatory). I want to tackle these obstacles from a new molecular angle, utilizing the profound impact of epigenetic mechanisms on the senescence process as well as on the functional imprinting of T lymphocytes. Epigenetic players such as DNA methylation essentially contribute to T cell differentiation and harbor the unique prospect to imprint a stable developmental and functional state in the genomic structure of a cell, as we could recently show in our basic immune-epigenetic studies. Therefore, I here propose to equip T lymphocytes with the required properties for their successful and safe therapeutic application, including their functional fine-tuning according to the clinical need by directed modifications of the epigenome ('Epi-tuning'). To reach these goals I want: 1) to reveal strategies for the directed manipulation of the epigenetically-driven mechanism of cellular senescence and 2) to apply state-of-the-art CRISPR/Cas9-mediated epigenetic editing approaches for the imprinting of a desired functional state of therapeutic T cell products. These innovative epigenetic 'one-shot' manipulations during the in vitro expansion phase should advance T cell therapy towards improved efficiency, stability as well as safety.'

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The information about "EPITUNE" are provided by the European Opendata Portal: CORDIS opendata.

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