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EpiTune SIGNED

Epigenetic fine-tuning of T cells for improved adoptive cell therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EpiTune project word cloud

Explore the words cloud of the EpiTune project. It provides you a very rough idea of what is the project "EpiTune" about.

basic    modifications    effect    cellular    settings    dna    structure    differentiation    shot    adoptive    acquisition    chronic    cells    tuning    expansion    stable    encounter    tackle    epigenetic    goals    vitro    epigenome    manipulation    safety    efficiency    organ    switch    sensitive    imprint    developmental    patient    infections    mechanism    mechanisms    opposite    angle    hampered    environment    fitness    cas9    senescence    methylation    fine    cell    mediated    reconstitution    lymphocytes    functional    safe    stability    molecular    pro    immunosuppressive    harbor    imprinting    manipulations    auto    therapy    combating    epigenetically    reactivity    inflammatory    transplantation    limits    prospect    immunity    clinical    innovative    obstacles    directed    fighting    equip    players    plasticity    cancer    transfusion    therapeutic    undesired    essentially    infusion    desired    survival    editing    utilizing    successful    genomic    crispr    profound    immune    reveal    epi    strategies   

Project "EpiTune" data sheet

The following table provides information about the project.

Coordinator
CHARITE - UNIVERSITAETSMEDIZIN BERLIN 

Organization address
address: Chariteplatz 1
city: BERLIN
postcode: 10117
website: www.charite.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙489˙725 €
 EC max contribution 1˙489˙725 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) coordinator 1˙489˙725.00

Map

 Project objective

'Adoptive T cell therapy is a promising approach in various clinical settings, from target-specific immune reconstitution fighting cancer and chronic infections to combating undesired immune reactivity during auto-immunity and after organ transplantation. However, its clinical application is currently hampered by: 1) the acquisition of senescence during the required in vitro expansion phase of T cells which limits their survival and fitness after infusion into the patient, and 2) the functional plasticity of T cells, which is sensitive to the inflammatory environment they encounter after transfusion and which might result in a functional switch from the desired effect (e.g. immunosuppressive) to the opposite one (pro-inflammatory). I want to tackle these obstacles from a new molecular angle, utilizing the profound impact of epigenetic mechanisms on the senescence process as well as on the functional imprinting of T lymphocytes. Epigenetic players such as DNA methylation essentially contribute to T cell differentiation and harbor the unique prospect to imprint a stable developmental and functional state in the genomic structure of a cell, as we could recently show in our basic immune-epigenetic studies. Therefore, I here propose to equip T lymphocytes with the required properties for their successful and safe therapeutic application, including their functional fine-tuning according to the clinical need by directed modifications of the epigenome ('Epi-tuning'). To reach these goals I want: 1) to reveal strategies for the directed manipulation of the epigenetically-driven mechanism of cellular senescence and 2) to apply state-of-the-art CRISPR/Cas9-mediated epigenetic editing approaches for the imprinting of a desired functional state of therapeutic T cell products. These innovative epigenetic 'one-shot' manipulations during the in vitro expansion phase should advance T cell therapy towards improved efficiency, stability as well as safety.'

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The information about "EPITUNE" are provided by the European Opendata Portal: CORDIS opendata.

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