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EpiTune SIGNED

Epigenetic fine-tuning of T cells for improved adoptive cell therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

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 EpiTune project word cloud

Explore the words cloud of the EpiTune project. It provides you a very rough idea of what is the project "EpiTune" about.

manipulation    mediated    equip    cas9    genomic    inflammatory    clinical    vitro    harbor    imprinting    senescence    strategies    epigenetically    tackle    imprint    hampered    cell    mechanisms    fine    encounter    combating    manipulations    angle    therapy    acquisition    structure    organ    cancer    settings    editing    basic    transfusion    opposite    crispr    goals    reveal    epigenome    modifications    directed    plasticity    immune    survival    adoptive    reactivity    limits    cells    infusion    reconstitution    molecular    immunity    epi    pro    environment    efficiency    differentiation    epigenetic    stable    expansion    obstacles    fighting    stability    effect    cellular    players    lymphocytes    infections    methylation    safety    utilizing    chronic    shot    undesired    desired    safe    transplantation    dna    sensitive    switch    fitness    tuning    mechanism    prospect    innovative    auto    therapeutic    immunosuppressive    essentially    developmental    patient    profound    functional    successful   

Project "EpiTune" data sheet

The following table provides information about the project.

Coordinator
CHARITE - UNIVERSITAETSMEDIZIN BERLIN 

Organization address
address: Chariteplatz 1
city: BERLIN
postcode: 10117
website: www.charite.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙489˙725 €
 EC max contribution 1˙489˙725 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) coordinator 1˙489˙725.00

Map

 Project objective

'Adoptive T cell therapy is a promising approach in various clinical settings, from target-specific immune reconstitution fighting cancer and chronic infections to combating undesired immune reactivity during auto-immunity and after organ transplantation. However, its clinical application is currently hampered by: 1) the acquisition of senescence during the required in vitro expansion phase of T cells which limits their survival and fitness after infusion into the patient, and 2) the functional plasticity of T cells, which is sensitive to the inflammatory environment they encounter after transfusion and which might result in a functional switch from the desired effect (e.g. immunosuppressive) to the opposite one (pro-inflammatory). I want to tackle these obstacles from a new molecular angle, utilizing the profound impact of epigenetic mechanisms on the senescence process as well as on the functional imprinting of T lymphocytes. Epigenetic players such as DNA methylation essentially contribute to T cell differentiation and harbor the unique prospect to imprint a stable developmental and functional state in the genomic structure of a cell, as we could recently show in our basic immune-epigenetic studies. Therefore, I here propose to equip T lymphocytes with the required properties for their successful and safe therapeutic application, including their functional fine-tuning according to the clinical need by directed modifications of the epigenome ('Epi-tuning'). To reach these goals I want: 1) to reveal strategies for the directed manipulation of the epigenetically-driven mechanism of cellular senescence and 2) to apply state-of-the-art CRISPR/Cas9-mediated epigenetic editing approaches for the imprinting of a desired functional state of therapeutic T cell products. These innovative epigenetic 'one-shot' manipulations during the in vitro expansion phase should advance T cell therapy towards improved efficiency, stability as well as safety.'

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The information about "EPITUNE" are provided by the European Opendata Portal: CORDIS opendata.

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