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EpiTune SIGNED

Epigenetic fine-tuning of T cells for improved adoptive cell therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

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 EpiTune project word cloud

Explore the words cloud of the EpiTune project. It provides you a very rough idea of what is the project "EpiTune" about.

stability    transfusion    survival    pro    obstacles    switch    differentiation    modifications    plasticity    cancer    fighting    combating    crispr    goals    editing    transplantation    settings    cellular    harbor    immune    cas9    patient    undesired    mechanism    genomic    tackle    methylation    therapeutic    innovative    reactivity    manipulations    prospect    inflammatory    players    cells    basic    auto    effect    mediated    utilizing    essentially    safety    safe    vitro    angle    immunity    successful    epigenetically    fine    desired    mechanisms    encounter    lymphocytes    epi    opposite    infections    profound    molecular    stable    directed    structure    expansion    acquisition    environment    epigenome    clinical    developmental    hampered    cell    shot    functional    therapy    imprinting    immunosuppressive    strategies    limits    epigenetic    sensitive    infusion    reconstitution    fitness    tuning    efficiency    adoptive    chronic    imprint    organ    manipulation    equip    dna    senescence    reveal   

Project "EpiTune" data sheet

The following table provides information about the project.

Coordinator
CHARITE - UNIVERSITAETSMEDIZIN BERLIN 

Organization address
address: Chariteplatz 1
city: BERLIN
postcode: 10117
website: www.charite.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙489˙725 €
 EC max contribution 1˙489˙725 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) coordinator 1˙489˙725.00

Map

 Project objective

'Adoptive T cell therapy is a promising approach in various clinical settings, from target-specific immune reconstitution fighting cancer and chronic infections to combating undesired immune reactivity during auto-immunity and after organ transplantation. However, its clinical application is currently hampered by: 1) the acquisition of senescence during the required in vitro expansion phase of T cells which limits their survival and fitness after infusion into the patient, and 2) the functional plasticity of T cells, which is sensitive to the inflammatory environment they encounter after transfusion and which might result in a functional switch from the desired effect (e.g. immunosuppressive) to the opposite one (pro-inflammatory). I want to tackle these obstacles from a new molecular angle, utilizing the profound impact of epigenetic mechanisms on the senescence process as well as on the functional imprinting of T lymphocytes. Epigenetic players such as DNA methylation essentially contribute to T cell differentiation and harbor the unique prospect to imprint a stable developmental and functional state in the genomic structure of a cell, as we could recently show in our basic immune-epigenetic studies. Therefore, I here propose to equip T lymphocytes with the required properties for their successful and safe therapeutic application, including their functional fine-tuning according to the clinical need by directed modifications of the epigenome ('Epi-tuning'). To reach these goals I want: 1) to reveal strategies for the directed manipulation of the epigenetically-driven mechanism of cellular senescence and 2) to apply state-of-the-art CRISPR/Cas9-mediated epigenetic editing approaches for the imprinting of a desired functional state of therapeutic T cell products. These innovative epigenetic 'one-shot' manipulations during the in vitro expansion phase should advance T cell therapy towards improved efficiency, stability as well as safety.'

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The information about "EPITUNE" are provided by the European Opendata Portal: CORDIS opendata.

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