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WATCH SIGNED

Well-Aging and the Tanycytic Control of Health

Total Cost €

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EC-Contrib. €

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Partnership

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 WATCH project word cloud

Explore the words cloud of the WATCH project. It provides you a very rough idea of what is the project "WATCH" about.

explore    fluid    demands    mouse    food    dynamically    brain    glial    pathological    experimental    modulation    dissection    signals    models    neurons    metabolic    anatomical    linchpins    exploration    technologies    molecularly    hypothalamus    impair    molecular    markers    energy    cognitive    lining    bench    obesity    specialized    therapeutic    versatile    pathophysiological    ventricle    watch    cognition    identification    age    aging    validation    neuroscience    actively    csf    disorders    shuttling    endothelial    neuroendocrine    act    median    genetic    pituitary    pharmacologically    circulation    biomarker    barrier    activating    regulating    organism    blood    function    cerebrospinal    morbid    heterogeneous    survival    evolve    circulating    functional    functions    synergistically    patients    deficits    levels    depends    physiological    homeostasis    overarching    tanycytes    directions    adapt    morphological    newly    intake    cells    tanycytic    shuttle    variety    classified    regulation    secretion    integrate    animal    floor    feedback    employ    hypothalamic    vivo    eminence    location    genetics    plasticity    portal    subgroups    neuropeptides    bedside   

Project "WATCH" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 9˙866˙250 €
 EC max contribution 9˙866˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-SyG
 Funding Scheme ERC-SyG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 4˙493˙750.00
2    UNIVERSITAET zu LUEBECK DE (LUBECK) participant 2˙875˙000.00
3    UNIVERSIDAD DE SANTIAGO DE COMPOSTELA ES (SANTIAGO DE COMPOSTELA) participant 2˙497˙500.00

Map

 Project objective

The survival of an organism depends on energy homeostasis, involving the control of neuroendocrine functions that integrate metabolic feedback and adapt the response of the organism to physiological demands. Tanycytes, specialized glial cells lining the floor of the third ventricle in the median eminence of the hypothalamus, act as linchpins of these processes, dynamically controlling the secretion of neuropeptides by hypothalamic neurons into the pituitary portal circulation and regulating blood-brain and blood-cerebrospinal fluid exchanges, both processes that depend on their morphological plasticity in response to the physiological state. In addition to their barrier properties, they actively shuttle circulating metabolic signals to hypothalamic neurons that control food intake. The overarching goal of WATCH is to synergistically employ state-of-the-art technologies in systems neuroscience, mouse genetics and bench-to-bedside research, to explore the role of these unique and versatile cells, providing new directions in biomarker research and new therapeutic approaches for a variety of disorders that impair well-aging. Our specific aims are: 1. Genetic dissection of the in vivo regulation, pathophysiological function and molecular markers of tanycytes classified according to their anatomical location. 2. Identification of novel heterogeneous, molecularly distinct tanycytes and associated endothelial cells and determining how these characteristics evolve under distinct physiological and pathological conditions. 3. Functional validation of newly classified subgroups of tanycytes and the specific modulation of the activity of these subgroups at the experimental level. 4. Exploration of the functional consequences of pharmacologically activating pathways required for the tanycytic shuttling of metabolic signals on their CSF levels of these factors, hypothalamic activity and cognition in animal models and patients with morbid obesity or age-related cognitive deficits.

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The information about "WATCH" are provided by the European Opendata Portal: CORDIS opendata.

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