Opendata, web and dolomites

WATCH SIGNED

Well-Aging and the Tanycytic Control of Health

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 WATCH project word cloud

Explore the words cloud of the WATCH project. It provides you a very rough idea of what is the project "WATCH" about.

demands    hypothalamic    neuroscience    heterogeneous    technologies    molecular    regulation    homeostasis    plasticity    circulating    overarching    intake    metabolic    animal    watch    explore    shuttle    organism    median    genetic    tanycytic    energy    floor    signals    cerebrospinal    functional    mouse    functions    fluid    pharmacologically    classified    blood    genetics    bench    versatile    shuttling    models    biomarker    tanycytes    obesity    exploration    cognition    synergistically    ventricle    molecularly    therapeutic    dynamically    endothelial    csf    location    depends    neurons    anatomical    activating    secretion    employ    impair    pathological    bedside    function    vivo    identification    newly    linchpins    cells    validation    physiological    morbid    markers    portal    brain    dissection    glial    age    neuropeptides    subgroups    neuroendocrine    evolve    food    experimental    integrate    aging    act    pituitary    deficits    eminence    disorders    feedback    regulating    barrier    levels    patients    modulation    lining    directions    actively    cognitive    specialized    variety    pathophysiological    hypothalamus    circulation    survival    morphological    adapt   

Project "WATCH" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 9˙866˙250 €
 EC max contribution 9˙866˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-SyG
 Funding Scheme ERC-SyG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 4˙493˙750.00
2    UNIVERSITAET zu LUEBECK DE (LUBECK) participant 2˙875˙000.00
3    UNIVERSIDAD DE SANTIAGO DE COMPOSTELA ES (SANTIAGO DE COMPOSTELA) participant 2˙497˙500.00

Map

 Project objective

The survival of an organism depends on energy homeostasis, involving the control of neuroendocrine functions that integrate metabolic feedback and adapt the response of the organism to physiological demands. Tanycytes, specialized glial cells lining the floor of the third ventricle in the median eminence of the hypothalamus, act as linchpins of these processes, dynamically controlling the secretion of neuropeptides by hypothalamic neurons into the pituitary portal circulation and regulating blood-brain and blood-cerebrospinal fluid exchanges, both processes that depend on their morphological plasticity in response to the physiological state. In addition to their barrier properties, they actively shuttle circulating metabolic signals to hypothalamic neurons that control food intake. The overarching goal of WATCH is to synergistically employ state-of-the-art technologies in systems neuroscience, mouse genetics and bench-to-bedside research, to explore the role of these unique and versatile cells, providing new directions in biomarker research and new therapeutic approaches for a variety of disorders that impair well-aging. Our specific aims are: 1. Genetic dissection of the in vivo regulation, pathophysiological function and molecular markers of tanycytes classified according to their anatomical location. 2. Identification of novel heterogeneous, molecularly distinct tanycytes and associated endothelial cells and determining how these characteristics evolve under distinct physiological and pathological conditions. 3. Functional validation of newly classified subgroups of tanycytes and the specific modulation of the activity of these subgroups at the experimental level. 4. Exploration of the functional consequences of pharmacologically activating pathways required for the tanycytic shuttling of metabolic signals on their CSF levels of these factors, hypothalamic activity and cognition in animal models and patients with morbid obesity or age-related cognitive deficits.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "WATCH" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "WATCH" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

KEYNESGROWTH (2020)

Economic Fluctuations, Productivity Growth and Stabilization Policies: A Keynesian Growth Perspective

Read More  

iNANOVAC4CANCER (2019)

BIOHYBRID AND BIODEGRADABLE NANOVACCINES FOR CANCER IMMUNOTHERAPY

Read More  

FICOMOL (2019)

Field Control of Cold Molecular Collisions

Read More