Opendata, web and dolomites


Targeting the epigenome: towards a better understanding of disease pathogenesis and novel therapeutic strategies in Multiple Sclerosis

Total Cost €


EC-Contrib. €






 Epi4MS project word cloud

Explore the words cloud of the Epi4MS project. It provides you a very rough idea of what is the project "Epi4MS" about.

progressive    molecular    diseases    chronic    biobank    unbiased    self    prioritize    aggressive    environmental    reversible    functional    throughput    screens    modulating    incurable    innovative    capture    sclerosis    preventing    nature    methylation    correcting    code    individuals    pathogenesis    stable    epigenome    stage    unpredictable    vitro    reversal    therapeutic    triggered    dna    starting    genetic    young    laboratory    immune    organ    mediate    gain    vivo    causal    therapies    mediated    ms    editing    inducing    paradigm    treating    modifiable    animal    predisposed    complement    rational    pathogenic    adults    added    gene    unknown    medicine    synergistic    utilize    point    extensive    regulators    spearheading    epigenetic    formulated    disease    exact    powerful    insights    expression    aberrant    discovery    dissect    cutting    marks    provides    alternative    cells    shift    combined    inflammatory    models    multiple    precision    corrected    genetically    disability    facets    mechanisms    regulate    edge    sustained   

Project "Epi4MS" data sheet

The following table provides information about the project.


Organization address
address: Nobels Vag 5
postcode: 17177

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙998˙798 €
 EC max contribution 1˙998˙798 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2024-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 1˙998˙798.00


 Project objective

Multiple Sclerosis (MS) is a leading cause of unpredictable and incurable progressive disability in young adults. Although the exact cause remains unknown, this immune-mediated disease is likely triggered by environmental factors in genetically predisposed individuals. I propose that epigenetic mechanisms, which regulate gene expression without affecting the genetic code, mediate the processes that cause MS and that aberrant epigenetic states can be corrected, spearheading the development of alternative therapies. We will exploit the stable and reversible nature of epigenetic marks, in particular DNA methylation, to gain insights into the novel modifiable disease mechanisms by studying the target organ in a way that has not been possible before. This highly ambitious project comprises three synergistic facets formulated in specific aims to: (i) identify epigenetic states that characterize the pathogenesis of MS, (ii) prioritize functional epigenetic states using high-throughput epigenome-screens, and (iii) develop novel approaches for precision medicine based on correcting causal epigenetic states. Our unique MS biobank combined with cutting-edge methodologies to capture pathogenic cells and measure their functional states provides a rational starting point to identify MS targets. I will complement this approach with studies of the functional impact of MS targets using innovative in vitro screens, with the added value of unbiased discovery of robust regulators of specific MS pathways. Finally, my laboratory has extensive experience with animal models of MS and I will utilize these powerful systems to dissect molecular mechanisms of MS targets and test the therapeutic potential of targeted epigenome editing in vivo. Our findings will set the stage for a paradigm-shift in studying and treating chronic inflammatory diseases based on preventing and modulating aggressive immune responses by inducing self-sustained reversal of aberrant epigenetic states.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EPI4MS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EPI4MS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

InsideChromatin (2019)

Towards Realistic Modelling of Nucleosome Organization Inside Functional Chromatin Domains

Read More  


The Enemy of the Good: Towards a Theory of Moral Progress

Read More  

ECOLBEH (2020)

The Ecology of Collective Behaviour

Read More