Explore the words cloud of the BioDisOrder project. It provides you a very rough idea of what is the project "BioDisOrder" about.
The following table provides information about the project.
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
|Coordinator Country||Italy [IT]|
|Total cost||1˙999˙945 €|
|EC max contribution||1˙999˙945 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2019-06-01 to 2024-05-31|
Take a look of project's partnership.
|1||UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II||IT (NAPOLI)||coordinator||1˙983˙827.00|
|2||IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE||UK (LONDON)||participant||16˙117.00|
Heterogeneous biomolecular mechanisms at the surface of cellular membranes are often fundamental to generate function and dysfunction in living systems. These processes are governed by transient and dynamical macromolecular interactions that pose tremendous challenges to current analytical tools, as the majority of these methods perform best in the study of well-defined and poorly dynamical systems. This proposal aims at a radical innovation in the characterisation of complex processes that are dominated by structural order and disorder, including those occurring at the surface of biological membranes such as cellular signalling, the assembly of molecular machinery, or the regulation vesicular trafficking. I outline a programme to realise a vision where the combination of experiments and theory can delineate a new analytical platform to study complex biochemical mechanisms at a multiscale level, and to elucidate their role in physiological and pathological contexts. To achieve this ambitious goal, my research team will develop tools based on the combination of nuclear magnetic resonance (NMR) spectroscopy and molecular simulations, which will enable probing the structure, dynamics, thermodynamics and kinetics of complex protein-protein and protein-membrane interactions occurring at the surface of cellular membranes. The ability to advance both the experimental and theoretical sides, and their combination, is fundamental to define the next generation of methods to achieve our transformative aims. We will provide evidence of the innovative nature of the proposed multiscale approach by addressing some of the great questions in neuroscience and elucidate the details of how functional and aberrant biological complexity is achieved via the fine tuning between structural order and disorder at the neuronal synapse.
|year||authors and title||journal||last update|
Matteo Runfola, Alfonso De Simone, Michele Vendruscolo, Christopher M. Dobson and Giuliana Fusco
The N-terminal Acetylation of Î±-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State
published pages: , ISSN: 2045-2322, DOI:
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The information about "BIODISORDER" are provided by the European Opendata Portal: CORDIS opendata.
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