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SYNKIT SIGNED

Synthetic Natural Killer Cells for Immunotherapy

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SYNKIT project word cloud

Explore the words cloud of the SYNKIT project. It provides you a very rough idea of what is the project "SYNKIT" about.

rejection    immunotherapy    human    completion    antigen    functional    underlying    genetic    missing    disarming    allogenicity    natural    laboratory    host    vitro    deficient    cells    synkit    tailor    education    setting    differentiation    self    function    ink    engineering    complete    immune    urging    hla    successful    cancer    ipscs    limited    molecular    platform    anti    diminishing    innovative    modulate    therapies    mechanism    escape    modulates    pluripotent    thereby    tumours    poor    treatment    triggers    expand    ipsc    possess    insights    deletion    option    killer    unravelled    broad    leukocyte    nk    recognition    absence    limitations    efficacy    impaired    introduction    reduce    ing    persistence    tumour    pave    combat    eliminate    allogeneic    worldwide    infusion    engineered    prevent    capacity    ligands    attractive    recipient    shelf    bottlenecks    generation    synthetic    cell    transferred    intrinsic    strategy    lack    stem    transfer    death    off   

Project "SYNKIT" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 191˙852 €
 EC max contribution 191˙852 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 191˙852.00

Map

 Project objective

'Cancer remains a leading cause of death worldwide, urging for innovative therapies. Infusion of natural killer (NK) cells, which possess an intrinsic capacity to eliminate cancer cells, is a promising treatment option for various tumours. Genetic engineering of NK cells before transfer allows to specifically tailor and modulate their anti-tumour responses. One particularly attractive strategy for broad implementation of NK cell immunotherapy in an “off-the-shelf” setting is to expand large numbers of NK cells from induced pluripotent stem cells (iPSCs). However, this approach is limited by two main bottlenecks: i) poor persistence of allogeneic iPSC-derived NK (iNK) cells due to rejection by the recipient immune system and ii) impaired functionality due to failure to achieve complete differentiation in vitro. The SYNKIT project seeks to address both of these current limitations through genetic engineering of iNK cells for increased persistence and function. Deletion of human leukocyte antigen (HLA) 'self-ligands' allows the transferred cells to escape from host T cells. However, absence of HLA also triggers “missing-self” recognition and rejection by host NK cells. In addition, new insights from the host laboratory into the molecular mechanism underlying NK cell education have unravelled a pathway of functional disarming in NK cells that lack self-ligands, further diminishing the anti-tumour efficacy of HLA-deficient NK cells. In SYNKIT, I will use HLA-deficient iNK cells as a platform to assess how introduction of synthetic self-ligands modulates the allogenicity and functionality of iNK cells. The overall goal of SYNKIT is to identify synthetic self-ligands, which reduce recognition by the host immune system and yet prevent functional disarming of the engineered iNK cells, thereby resulting in optimised anti-tumour function. Successful completion of SYNKIT will pave the way for development of next generation immunotherapy to more effectively combat cancer. '

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The information about "SYNKIT" are provided by the European Opendata Portal: CORDIS opendata.

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