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SYNKIT SIGNED

Synthetic Natural Killer Cells for Immunotherapy

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SYNKIT project word cloud

Explore the words cloud of the SYNKIT project. It provides you a very rough idea of what is the project "SYNKIT" about.

insights    laboratory    immune    deficient    successful    human    engineered    option    complete    underlying    treatment    pave    innovative    introduction    cells    tailor    shelf    genetic    host    anti    ligands    limitations    eliminate    combat    transferred    rejection    deletion    synkit    strategy    thereby    efficacy    completion    prevent    cell    unravelled    cancer    pluripotent    hla    recipient    leukocyte    synthetic    functional    self    intrinsic    recognition    differentiation    education    poor    death    allogenicity    limited    lack    escape    vitro    mechanism    natural    killer    urging    expand    ink    molecular    capacity    modulate    therapies    stem    off    engineering    function    worldwide    allogeneic    infusion    immunotherapy    disarming    platform    triggers    tumour    broad    missing    tumours    setting    antigen    diminishing    nk    absence    bottlenecks    modulates    ing    attractive    persistence    generation    ipscs    impaired    reduce    transfer    possess    ipsc   

Project "SYNKIT" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 191˙852 €
 EC max contribution 191˙852 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 191˙852.00

Map

 Project objective

'Cancer remains a leading cause of death worldwide, urging for innovative therapies. Infusion of natural killer (NK) cells, which possess an intrinsic capacity to eliminate cancer cells, is a promising treatment option for various tumours. Genetic engineering of NK cells before transfer allows to specifically tailor and modulate their anti-tumour responses. One particularly attractive strategy for broad implementation of NK cell immunotherapy in an “off-the-shelf” setting is to expand large numbers of NK cells from induced pluripotent stem cells (iPSCs). However, this approach is limited by two main bottlenecks: i) poor persistence of allogeneic iPSC-derived NK (iNK) cells due to rejection by the recipient immune system and ii) impaired functionality due to failure to achieve complete differentiation in vitro. The SYNKIT project seeks to address both of these current limitations through genetic engineering of iNK cells for increased persistence and function. Deletion of human leukocyte antigen (HLA) 'self-ligands' allows the transferred cells to escape from host T cells. However, absence of HLA also triggers “missing-self” recognition and rejection by host NK cells. In addition, new insights from the host laboratory into the molecular mechanism underlying NK cell education have unravelled a pathway of functional disarming in NK cells that lack self-ligands, further diminishing the anti-tumour efficacy of HLA-deficient NK cells. In SYNKIT, I will use HLA-deficient iNK cells as a platform to assess how introduction of synthetic self-ligands modulates the allogenicity and functionality of iNK cells. The overall goal of SYNKIT is to identify synthetic self-ligands, which reduce recognition by the host immune system and yet prevent functional disarming of the engineered iNK cells, thereby resulting in optimised anti-tumour function. Successful completion of SYNKIT will pave the way for development of next generation immunotherapy to more effectively combat cancer. '

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The information about "SYNKIT" are provided by the European Opendata Portal: CORDIS opendata.

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