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Impact of maternal Adrenomedullin on the Microbiome and Gut health: insights into preventing chronic intestinal disorders

Total Cost €


EC-Contrib. €






 I-AM-GUT project word cloud

Explore the words cloud of the I-AM-GUT project. It provides you a very rough idea of what is the project "I-AM-GUT" about.

hypothesizes    secondment    transgenic    tool    fellow    uncover    transferable    susceptibility    basis    lactation    fellowship    intervention    disciplinary    pathology    disseminate    protective    human    techniques    sequencing    organoids    hybrisation    prevention    knock    diagnostic    generating    gut    relatively    economic    generation    supervisor    immune    adrenomedullin    expertise    host    cytometry    mechanisms    microbiome    concentrations    reveal    am    molecular    life    inflammatory    colitis    endogenous    position    hormone    chronic    exact    prognostic    dysbiosis    healthy    onset    ultimately    gastrointestinal    gland    researcher    place    plans    culture    apc    maternal    carefully    digital    she    first    bowel    microbiota    preventing    models    physiology    ireland    naturally    match    inflammation    ucd    independent    infant    strategies    little    disease    administration    flow    regulate    global    mice    progression    skills    situ    biology    model    cell    final    compensate    burden    ibd    unravel    milk    goals    influence    biomarker    breast    mammary    conditional    designed    nutritional    gain   

Project "I-AM-GUT" data sheet

The following table provides information about the project.


Organization address
city: Cork
postcode: T12 YN60

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 184˙590 €
 EC max contribution 184˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2021-10-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Inflammatory Bowel Disease (IBD) is a chronic gastrointestinal inflammation that has become a global disease with a high economic burden. Adrenomedullin (AM), a hormone associated with gut microbiota and physiology, is naturally present at high concentrations in maternal milk and during lactation. Using a conditional model for AM the fellow identified a protective role of endogenous AM in IBD onset, however relatively little is known about its exact role in early-life, in colitis development or as a potential diagnostic tool for IBD. The fellow hypothesizes that maternal AM’s impact on the breast and gut microbiome may regulate gut and immune development and colitis susceptibility. By creating the first mammary gland conditional knock out for AM, she will uncover novel disease mechanisms and provide the basis for new diagnostic and prevention strategies for IBD. The final goals of this multi-disciplinary project are 1) to unravel the impact of AM on the breast microbiome, the maternal AM influence on healthy infant gut development and the prevention of colitis; 2) to reveal the impact that nutritional intervention and AM administration have on milk and gut microbiome to compensate for dysbiosis and in preventing colitis progression; 3) to evaluate the value of AM as an independent prognostic biomarker for IBD. The project has been carefully designed to match the fellow’s expertise in generating transgenic mice, AM biology and molecular techniques; the expertise of the host institution (APC Microbiome Ireland) in next generation sequencing, cell culture models (organoids), flow cytometry and human studies; and the expertise of the secondment supervisor (UCD) in in situ hybrisation and digital pathology technology. Plans to improve the fellow’s ability to disseminate research findings, gain transferable skills, and learn to manage a project are in place. Ultimately at the end of this fellowship, she will have advanced her position to become an independent researcher.

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The information about "I-AM-GUT" are provided by the European Opendata Portal: CORDIS opendata.

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