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Impact of maternal Adrenomedullin on the Microbiome and Gut health: insights into preventing chronic intestinal disorders

Total Cost €


EC-Contrib. €






 I-AM-GUT project word cloud

Explore the words cloud of the I-AM-GUT project. It provides you a very rough idea of what is the project "I-AM-GUT" about.

endogenous    immune    ultimately    position    skills    unravel    inflammatory    concentrations    transgenic    goals    sequencing    dysbiosis    colitis    digital    relatively    little    naturally    uncover    techniques    disseminate    bowel    cell    prognostic    infant    nutritional    compensate    generation    place    physiology    final    onset    am    she    influence    first    regulate    disease    ucd    economic    knock    conditional    host    milk    situ    preventing    mammary    microbiota    tool    hypothesizes    protective    flow    cytometry    gland    match    inflammation    progression    human    secondment    expertise    prevention    maternal    fellow    intervention    healthy    hybrisation    reveal    hormone    microbiome    exact    global    breast    adrenomedullin    gastrointestinal    models    researcher    mice    administration    transferable    biomarker    basis    fellowship    generating    diagnostic    model    organoids    strategies    pathology    biology    carefully    ibd    gain    culture    ireland    independent    designed    molecular    plans    lactation    supervisor    life    chronic    susceptibility    burden    apc    disciplinary    mechanisms    gut   

Project "I-AM-GUT" data sheet

The following table provides information about the project.


Organization address
city: Cork
postcode: T12 YN60

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 184˙590 €
 EC max contribution 184˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2021-10-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Inflammatory Bowel Disease (IBD) is a chronic gastrointestinal inflammation that has become a global disease with a high economic burden. Adrenomedullin (AM), a hormone associated with gut microbiota and physiology, is naturally present at high concentrations in maternal milk and during lactation. Using a conditional model for AM the fellow identified a protective role of endogenous AM in IBD onset, however relatively little is known about its exact role in early-life, in colitis development or as a potential diagnostic tool for IBD. The fellow hypothesizes that maternal AM’s impact on the breast and gut microbiome may regulate gut and immune development and colitis susceptibility. By creating the first mammary gland conditional knock out for AM, she will uncover novel disease mechanisms and provide the basis for new diagnostic and prevention strategies for IBD. The final goals of this multi-disciplinary project are 1) to unravel the impact of AM on the breast microbiome, the maternal AM influence on healthy infant gut development and the prevention of colitis; 2) to reveal the impact that nutritional intervention and AM administration have on milk and gut microbiome to compensate for dysbiosis and in preventing colitis progression; 3) to evaluate the value of AM as an independent prognostic biomarker for IBD. The project has been carefully designed to match the fellow’s expertise in generating transgenic mice, AM biology and molecular techniques; the expertise of the host institution (APC Microbiome Ireland) in next generation sequencing, cell culture models (organoids), flow cytometry and human studies; and the expertise of the secondment supervisor (UCD) in in situ hybrisation and digital pathology technology. Plans to improve the fellow’s ability to disseminate research findings, gain transferable skills, and learn to manage a project are in place. Ultimately at the end of this fellowship, she will have advanced her position to become an independent researcher.

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The information about "I-AM-GUT" are provided by the European Opendata Portal: CORDIS opendata.

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