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I-AM-GUT SIGNED

Impact of maternal Adrenomedullin on the Microbiome and Gut health: insights into preventing chronic intestinal disorders

Total Cost €

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EC-Contrib. €

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Partnership

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 I-AM-GUT project word cloud

Explore the words cloud of the I-AM-GUT project. It provides you a very rough idea of what is the project "I-AM-GUT" about.

disciplinary    susceptibility    am    skills    compensate    naturally    culture    physiology    host    ibd    infant    disease    protective    techniques    microbiota    onset    regulate    gastrointestinal    expertise    relatively    carefully    researcher    gland    inflammation    bowel    breast    chronic    mechanisms    hybrisation    exact    supervisor    fellowship    prevention    unravel    goals    milk    place    model    life    first    hypothesizes    models    final    cell    gut    administration    diagnostic    preventing    apc    hormone    knock    prognostic    concentrations    transgenic    generation    healthy    pathology    conditional    generating    tool    biomarker    mammary    match    she    influence    endogenous    organoids    ireland    reveal    nutritional    ucd    biology    immune    designed    maternal    digital    global    mice    economic    adrenomedullin    colitis    transferable    burden    ultimately    secondment    position    sequencing    plans    lactation    progression    independent    human    uncover    situ    disseminate    fellow    gain    inflammatory    cytometry    molecular    flow    intervention    dysbiosis    microbiome    strategies    little    basis   

Project "I-AM-GUT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK 

Organization address
address: WESTERN ROAD
city: Cork
postcode: T12 YN60
website: www.ucc.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 184˙590 €
 EC max contribution 184˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK IE (Cork) coordinator 184˙590.00

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 Project objective

Inflammatory Bowel Disease (IBD) is a chronic gastrointestinal inflammation that has become a global disease with a high economic burden. Adrenomedullin (AM), a hormone associated with gut microbiota and physiology, is naturally present at high concentrations in maternal milk and during lactation. Using a conditional model for AM the fellow identified a protective role of endogenous AM in IBD onset, however relatively little is known about its exact role in early-life, in colitis development or as a potential diagnostic tool for IBD. The fellow hypothesizes that maternal AM’s impact on the breast and gut microbiome may regulate gut and immune development and colitis susceptibility. By creating the first mammary gland conditional knock out for AM, she will uncover novel disease mechanisms and provide the basis for new diagnostic and prevention strategies for IBD. The final goals of this multi-disciplinary project are 1) to unravel the impact of AM on the breast microbiome, the maternal AM influence on healthy infant gut development and the prevention of colitis; 2) to reveal the impact that nutritional intervention and AM administration have on milk and gut microbiome to compensate for dysbiosis and in preventing colitis progression; 3) to evaluate the value of AM as an independent prognostic biomarker for IBD. The project has been carefully designed to match the fellow’s expertise in generating transgenic mice, AM biology and molecular techniques; the expertise of the host institution (APC Microbiome Ireland) in next generation sequencing, cell culture models (organoids), flow cytometry and human studies; and the expertise of the secondment supervisor (UCD) in in situ hybrisation and digital pathology technology. Plans to improve the fellow’s ability to disseminate research findings, gain transferable skills, and learn to manage a project are in place. Ultimately at the end of this fellowship, she will have advanced her position to become an independent researcher.

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