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I-AM-GUT SIGNED

Impact of maternal Adrenomedullin on the Microbiome and Gut health: insights into preventing chronic intestinal disorders

Total Cost €

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EC-Contrib. €

0

Partnership

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 I-AM-GUT project word cloud

Explore the words cloud of the I-AM-GUT project. It provides you a very rough idea of what is the project "I-AM-GUT" about.

diagnostic    match    plans    reveal    inflammation    she    digital    little    pathology    burden    influence    carefully    life    hypothesizes    disciplinary    bowel    expertise    transgenic    hybrisation    infant    apc    inflammatory    prevention    nutritional    designed    biology    progression    ibd    dysbiosis    fellowship    gain    maternal    organoids    am    physiology    endogenous    gut    supervisor    compensate    gastrointestinal    regulate    final    relatively    place    transferable    intervention    susceptibility    milk    position    economic    onset    techniques    naturally    healthy    hormone    mechanisms    chronic    cell    skills    prognostic    disseminate    models    host    conditional    mice    model    breast    molecular    culture    goals    ucd    ultimately    microbiota    microbiome    unravel    gland    generating    uncover    human    concentrations    generation    secondment    tool    situ    cytometry    global    exact    biomarker    knock    lactation    immune    administration    adrenomedullin    ireland    sequencing    disease    strategies    preventing    researcher    flow    colitis    first    protective    fellow    independent    basis    mammary   

Project "I-AM-GUT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK 

Organization address
address: WESTERN ROAD
city: Cork
postcode: T12 YN60
website: www.ucc.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 184˙590 €
 EC max contribution 184˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK IE (Cork) coordinator 184˙590.00

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 Project objective

Inflammatory Bowel Disease (IBD) is a chronic gastrointestinal inflammation that has become a global disease with a high economic burden. Adrenomedullin (AM), a hormone associated with gut microbiota and physiology, is naturally present at high concentrations in maternal milk and during lactation. Using a conditional model for AM the fellow identified a protective role of endogenous AM in IBD onset, however relatively little is known about its exact role in early-life, in colitis development or as a potential diagnostic tool for IBD. The fellow hypothesizes that maternal AM’s impact on the breast and gut microbiome may regulate gut and immune development and colitis susceptibility. By creating the first mammary gland conditional knock out for AM, she will uncover novel disease mechanisms and provide the basis for new diagnostic and prevention strategies for IBD. The final goals of this multi-disciplinary project are 1) to unravel the impact of AM on the breast microbiome, the maternal AM influence on healthy infant gut development and the prevention of colitis; 2) to reveal the impact that nutritional intervention and AM administration have on milk and gut microbiome to compensate for dysbiosis and in preventing colitis progression; 3) to evaluate the value of AM as an independent prognostic biomarker for IBD. The project has been carefully designed to match the fellow’s expertise in generating transgenic mice, AM biology and molecular techniques; the expertise of the host institution (APC Microbiome Ireland) in next generation sequencing, cell culture models (organoids), flow cytometry and human studies; and the expertise of the secondment supervisor (UCD) in in situ hybrisation and digital pathology technology. Plans to improve the fellow’s ability to disseminate research findings, gain transferable skills, and learn to manage a project are in place. Ultimately at the end of this fellowship, she will have advanced her position to become an independent researcher.

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The information about "I-AM-GUT" are provided by the European Opendata Portal: CORDIS opendata.

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