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Desiccation Survival SIGNED

Discovery of intrinsically disordered sequences conferring desiccation survival

Total Cost €


EC-Contrib. €






 Desiccation Survival project word cloud

Explore the words cloud of the Desiccation Survival project. It provides you a very rough idea of what is the project "Desiccation Survival" about.

mediated    vivo    tested    abundant    periods    unfolding    pipeline    functional    machine    sequences    family    survive    glass    computational    underlying    intracellular    vitro    screen    solids    aid    unknown    paradigm    assay    algorithms    throughput    transition    vitrified    sampling    space    confer    hits    materials    undergo    functions    form    heat    questions    validate    protect    perform    aggregate    protein    unfold    ing    dryness    generate    dry    engineering    survival    intrinsically    idps    extract    shown    disordered    discover    protective    learned    question    stress    cytosolic    sequence    micro    protection    extremely    death    biology    rescue    gelation    determinants    rationally    cahs    library    function    unravel    phylum    learning    desiccation    screening    biomaterials    proteins    animals    idp    designing    soluble    cell    cells    organisms    irreversibly    fundamental    aggregation    tardigrades   

Project "Desiccation Survival" data sheet

The following table provides information about the project.


Organization address
postcode: SN2 1FL
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Desiccation is a form of stress wherein extremely dry conditions cause intracellular proteins to unfold and aggregate irreversibly, resulting in cell-death. How do cells and organisms survive desiccation is a fundamental question in biology. Cytosolic Abundant Heat Soluble (CAHS) proteins, a family of intrinsically disordered proteins (IDPs) in tardigrades (a phylum of micro-animals), have been shown to be important for their survival during long periods of dryness. Under desiccation condition, CAHS proteins undergo glass-transition and gelation to form vitrified solids that protect intracellular proteins from unfolding and aggregation. However, the features of CAHS proteins that confer protection are unknown. Here, I aim to unravel the sequence determinants of CAHS protein functions, by addressing 3 specific questions:

Aim 1: What are the sequence features that promote glass-transition and gelation in CAHS proteins? Aim 2: Can we discover new sequences that can rescue cells from desiccation? Aim 3: What is the sequence-to-function paradigm underlying IDP-mediated desiccation survival?

I will (i) perform computational analysis of existing CAHS proteins to extract their sequence features to design a library for adequate sampling of the sequence space; (ii) screen the library with a high-throughput survival-based assay and validate the hits both in vitro and in vivo; (iii) analyse the results with machine learning algorithms to generate characteristic sequence features underlying protective glass-transition. The learned features will be tested by rationally designing and screening a new sequence library for desiccation survival. This project will provide fundamental sequence-level understanding of how IDPs promote stress response, specifically via glass-transition during desiccation. Moreover, the materials and pipeline generated and the findings of this study will aid in engineering functional biomaterials.

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The information about "DESICCATION SURVIVAL" are provided by the European Opendata Portal: CORDIS opendata.

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