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REBELLION SIGNED

Light-REsponsive Nanomachines for Targeted Eradication of BactErial Pathogens in LocaLised InfectIONs

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 REBELLION project word cloud

Explore the words cloud of the REBELLION project. It provides you a very rough idea of what is the project "REBELLION" about.

discovery    preserve    evaluation    safety    university    chemical    training    selectivity    excellence    beneficiary    career    vivo    clinically    competencies    researcher    infection    idisba    photobiology    vital    action    rebellion    therapeutics    stone    mnms    widen    eclectic    21st    amr    light    antimicrobials    class    contribution    stepping    strategy    therapeutic    core    expertise    alternative    international    viability    mankind    minimal    independent    therapy    threat    clinical    vitro    tissues    trials    advantage    strategies    century    rice    scientists    spain    catalyze    resistance    multidisciplinary    expert    efficacy    bacterial    gama    damage    nanotechnology    geared    nanomachine    fellow    antibiotic    molecular    skill    cells    co    producing    nanomachines    entirely    championed    host    mammalian    usa    antimicrobial    network    synthesis    minimizing    endeavor    trained    inactivation    pathogens    mature    drug    toward    microbial    antibiotics    responsive    critical    combines   

Project "REBELLION" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT D'INVESTIGACIO SANITARIA ILLES BALEARS 

Organization address
address: CARRETERA DE VALLDEMOSSA, 79
city: PALMA
postcode: 7120
website: www.caubet-cimera.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 245˙732 €
 EC max contribution 245˙732 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-GF
 Starting year 2020
 Duration (year-month-day) from 2020-01-06   to  2023-01-05

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT D'INVESTIGACIO SANITARIA ILLES BALEARS ES (PALMA) coordinator 245˙732.00
2    GAMA THERAPEUTICS LLC US (PEPPERELL MA) partner 0.00

Map

 Project objective

Antimicrobial resistance (AMR) has been identified as a major threat to mankind in the 21st century. Thus, there is a critical need to develop new antimicrobials and new delivery strategies to preserve the viability of the existing antibiotics. One such strategy is the use of molecular nanomachines (MNMs) for targeted and controlled inactivation of bacterial pathogens. REBELLION aims to develop new light responsive MNMs against bacterial pathogens with minimal damage to mammalian tissues. This strategy will provide a therapeutic advantage in terms of efficacy and selectivity compared with current therapeutics while minimizing the potential for the development of AMR. The proposed research programme combines (1) chemical synthesis of new MNMs, (2) assessment of their efficacy against clinically relevant bacterial pathogens, (3) evaluation of their safety to mammalian cells and (4) in vivo efficacy testing. The results obtained have the potential to lead to an alternative, entirely novel class of antimicrobials (MNMs) and to become a stepping stone towards future clinical trials. REBELLION is a vital, multidisciplinary and international endeavor that will bring together this fellow’s core expertise in microbial photobiology with (1) antibiotic resistance and infection at IdISBa (beneficiary, Spain), (2) state-of-the-art technology in light-driven antimicrobial therapy, and experience in in vitro and in vivo drug efficacy testing championed by GAMA Therapeutics (host, USA) and (3) expert knowledge in nanomachine synthesis by the Nanotechnology Department of Rice University (co-host, USA). I will be trained by top-level scientists and widen my network and competencies through advanced training in nanotechnology, infection, and drug development and testing. This action will catalyze my career into an independent and mature researcher with an eclectic skill set geared toward producing a unique contribution to European excellence in antimicrobial discovery technology.

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The information about "REBELLION" are provided by the European Opendata Portal: CORDIS opendata.

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