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DIFTERIA SIGNED

Development of a simple and rapid assay for early diphtheria diagnosis.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DIFTERIA project word cloud

Explore the words cloud of the DIFTERIA project. It provides you a very rough idea of what is the project "DIFTERIA" about.

ussr    strip    prophylaxis    indicate    cultivation    assay    absence    bacterial    spread    clinical    treatment    detection    days    reagent    ics    prepared    laboratory    protection    prevent    outbreaks    circulation    russia    epidemic    selective    mostly    antibiotic    5000    incidence    immunochromatographic    declined    diphtheria    paralysis    diphtheriae    times    diagnosis    during    quality    reduce    efficient    former    dt    combination    reports    1990s    save    people    accuracy    medium    population    poses    standard    africa    unvaccinated    anti    toxigenic    toxin    persons    international    vaccination    countries    designed    instead    hours    poor    affordable    commercially    preventive    stop    kit    children    disease    immunological    substantially    manual    asia    diagnostic    initiation    complications    risk    revealed    regard    deaths    recommended    serious    indication    diphtheritic    apparatus    liquid    200    indigenous    lives    heart    migrants   

Project "DIFTERIA" data sheet

The following table provides information about the project.

Coordinator
SENOVA GESELLSCHAFT FUR BIOWISSENSCHAFT UND TECHNICK MBH 

Organization address
address: INDUSTRIESTR. 8
city: WEIMAR
postcode: 99427
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 174˙806 €
 EC max contribution 174˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SENOVA GESELLSCHAFT FUR BIOWISSENSCHAFT UND TECHNICK MBH DE (WEIMAR) coordinator 174˙806.00

Map

 Project objective

During 1990s, there was an epidemic of diphtheria in Russia and other countries of the former USSR affecting about 200, 000 people with 5000 deaths. Although diphtheria incidence in Russia has declined substantially, recent reports from several EU countries indicate circulation of toxigenic C. diphtheriae among migrants from Asia and Africa as well as children’s deaths among indigenous population. Toxigenic C. diphtheriae poses a serious risk for unvaccinated persons and persons with low level of immunological protection, the number of which in recent times in Europe has increased. The International system of quality control revealed poor state of laboratory diagnosis of diphtheria in EU countries, which means we are not prepared for the possible outbreaks. This is mostly due to the absence of simple, standard and reliable diagnostic methods. The leading element in the diphtheria laboratory diagnostic approach is a detection of the bacterial toxin. In this regard, it is proposed to develop non-apparatus immunochromatographic strip (ICS) test for diphtheria toxin (DT) indication. In addition a liquid selective medium for the clinical sample cultivation will be designed. A combination of the ICS test and the medium will represent a novel assay for early diphtheria diagnosis. The reagent kit will be commercially produced. The availability of simple, reliable and affordable ICS assay for DT detection will increase the accuracy of diphtheria diagnosis in EU and other countries and reduce the duration of its execution up to 6 hours (instead of 5-7 days as recommended by the WHO manual). The efficient early diphtheria diagnosis will enable timely initiation of anti-diphtheritic treatment that will save lives, prevent the development of complications (heart failure, paralysis), as well as stop the spread of the disease through initiation of preventive measures (vaccination and antibiotic prophylaxis) in case of disease outbreaks.

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The information about "DIFTERIA" are provided by the European Opendata Portal: CORDIS opendata.

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