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Development of a simple and rapid assay for early diphtheria diagnosis.

Total Cost €


EC-Contrib. €






 DIFTERIA project word cloud

Explore the words cloud of the DIFTERIA project. It provides you a very rough idea of what is the project "DIFTERIA" about.

combination    selective    poor    migrants    stop    bacterial    protection    russia    200    risk    epidemic    cultivation    accuracy    diphtheria    initiation    reports    indicate    during    apparatus    antibiotic    prepared    declined    vaccination    prevent    complications    commercially    children    instead    former    diagnostic    preventive    designed    times    kit    africa    efficient    reduce    asia    detection    spread    indication    outbreaks    standard    ics    liquid    ussr    unvaccinated    affordable    population    treatment    prophylaxis    incidence    days    quality    medium    clinical    1990s    save    assay    reagent    deaths    anti    diphtheritic    immunochromatographic    paralysis    diagnosis    mostly    countries    absence    diphtheriae    circulation    recommended    lives    indigenous    people    heart    substantially    regard    manual    serious    laboratory    immunological    5000    hours    strip    international    toxigenic    persons    revealed    poses    disease    dt    toxin   

Project "DIFTERIA" data sheet

The following table provides information about the project.


Organization address
address: INDUSTRIESTR. 8
city: WEIMAR
postcode: 99427
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 174˙806 €
 EC max contribution 174˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

During 1990s, there was an epidemic of diphtheria in Russia and other countries of the former USSR affecting about 200, 000 people with 5000 deaths. Although diphtheria incidence in Russia has declined substantially, recent reports from several EU countries indicate circulation of toxigenic C. diphtheriae among migrants from Asia and Africa as well as children’s deaths among indigenous population. Toxigenic C. diphtheriae poses a serious risk for unvaccinated persons and persons with low level of immunological protection, the number of which in recent times in Europe has increased. The International system of quality control revealed poor state of laboratory diagnosis of diphtheria in EU countries, which means we are not prepared for the possible outbreaks. This is mostly due to the absence of simple, standard and reliable diagnostic methods. The leading element in the diphtheria laboratory diagnostic approach is a detection of the bacterial toxin. In this regard, it is proposed to develop non-apparatus immunochromatographic strip (ICS) test for diphtheria toxin (DT) indication. In addition a liquid selective medium for the clinical sample cultivation will be designed. A combination of the ICS test and the medium will represent a novel assay for early diphtheria diagnosis. The reagent kit will be commercially produced. The availability of simple, reliable and affordable ICS assay for DT detection will increase the accuracy of diphtheria diagnosis in EU and other countries and reduce the duration of its execution up to 6 hours (instead of 5-7 days as recommended by the WHO manual). The efficient early diphtheria diagnosis will enable timely initiation of anti-diphtheritic treatment that will save lives, prevent the development of complications (heart failure, paralysis), as well as stop the spread of the disease through initiation of preventive measures (vaccination and antibiotic prophylaxis) in case of disease outbreaks.

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The information about "DIFTERIA" are provided by the European Opendata Portal: CORDIS opendata.

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