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Development of a simple and rapid assay for early diphtheria diagnosis.

Total Cost €


EC-Contrib. €






 DIFTERIA project word cloud

Explore the words cloud of the DIFTERIA project. It provides you a very rough idea of what is the project "DIFTERIA" about.

migrants    deaths    commercially    poses    protection    lives    kit    epidemic    diagnosis    serious    reduce    hours    ics    strip    detection    ussr    children    former    indigenous    outbreaks    preventive    assay    paralysis    complications    medium    antibiotic    combination    efficient    international    diphtheriae    russia    absence    stop    toxin    liquid    prevent    cultivation    reagent    diphtheria    vaccination    treatment    prophylaxis    spread    during    laboratory    instead    diphtheritic    circulation    quality    toxigenic    save    clinical    population    africa    1990s    mostly    initiation    indicate    poor    selective    bacterial    dt    apparatus    diagnostic    risk    affordable    5000    heart    accuracy    asia    revealed    days    incidence    indication    countries    unvaccinated    declined    200    persons    times    standard    immunological    manual    designed    immunochromatographic    prepared    substantially    reports    people    regard    disease    recommended    anti   

Project "DIFTERIA" data sheet

The following table provides information about the project.


Organization address
address: INDUSTRIESTR. 8
city: WEIMAR
postcode: 99427
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 174˙806 €
 EC max contribution 174˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

During 1990s, there was an epidemic of diphtheria in Russia and other countries of the former USSR affecting about 200, 000 people with 5000 deaths. Although diphtheria incidence in Russia has declined substantially, recent reports from several EU countries indicate circulation of toxigenic C. diphtheriae among migrants from Asia and Africa as well as children’s deaths among indigenous population. Toxigenic C. diphtheriae poses a serious risk for unvaccinated persons and persons with low level of immunological protection, the number of which in recent times in Europe has increased. The International system of quality control revealed poor state of laboratory diagnosis of diphtheria in EU countries, which means we are not prepared for the possible outbreaks. This is mostly due to the absence of simple, standard and reliable diagnostic methods. The leading element in the diphtheria laboratory diagnostic approach is a detection of the bacterial toxin. In this regard, it is proposed to develop non-apparatus immunochromatographic strip (ICS) test for diphtheria toxin (DT) indication. In addition a liquid selective medium for the clinical sample cultivation will be designed. A combination of the ICS test and the medium will represent a novel assay for early diphtheria diagnosis. The reagent kit will be commercially produced. The availability of simple, reliable and affordable ICS assay for DT detection will increase the accuracy of diphtheria diagnosis in EU and other countries and reduce the duration of its execution up to 6 hours (instead of 5-7 days as recommended by the WHO manual). The efficient early diphtheria diagnosis will enable timely initiation of anti-diphtheritic treatment that will save lives, prevent the development of complications (heart failure, paralysis), as well as stop the spread of the disease through initiation of preventive measures (vaccination and antibiotic prophylaxis) in case of disease outbreaks.

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The information about "DIFTERIA" are provided by the European Opendata Portal: CORDIS opendata.

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