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DIFTERIA SIGNED

Development of a simple and rapid assay for early diphtheria diagnosis.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DIFTERIA project word cloud

Explore the words cloud of the DIFTERIA project. It provides you a very rough idea of what is the project "DIFTERIA" about.

prevent    treatment    laboratory    protection    preventive    affordable    immunochromatographic    deaths    circulation    spread    declined    asia    stop    regard    reduce    toxigenic    mostly    poses    risk    clinical    days    ussr    cultivation    during    migrants    selective    diagnosis    times    diphtheriae    200    commercially    dt    quality    detection    initiation    reagent    persons    epidemic    outbreaks    diphtheria    combination    international    population    heart    vaccination    reports    disease    1990s    indigenous    people    unvaccinated    revealed    5000    indicate    apparatus    countries    lives    complications    prophylaxis    save    toxin    poor    paralysis    medium    instead    ics    liquid    hours    strip    diagnostic    recommended    manual    children    standard    assay    kit    incidence    russia    accuracy    antibiotic    absence    indication    immunological    serious    former    diphtheritic    prepared    substantially    africa    efficient    anti    bacterial    designed   

Project "DIFTERIA" data sheet

The following table provides information about the project.

Coordinator
SENOVA GESELLSCHAFT FUR BIOWISSENSCHAFT UND TECHNICK MBH 

Organization address
address: INDUSTRIESTR. 8
city: WEIMAR
postcode: 99427
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 174˙806 €
 EC max contribution 174˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SENOVA GESELLSCHAFT FUR BIOWISSENSCHAFT UND TECHNICK MBH DE (WEIMAR) coordinator 174˙806.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

During 1990s, there was an epidemic of diphtheria in Russia and other countries of the former USSR affecting about 200, 000 people with 5000 deaths. Although diphtheria incidence in Russia has declined substantially, recent reports from several EU countries indicate circulation of toxigenic C. diphtheriae among migrants from Asia and Africa as well as children’s deaths among indigenous population. Toxigenic C. diphtheriae poses a serious risk for unvaccinated persons and persons with low level of immunological protection, the number of which in recent times in Europe has increased. The International system of quality control revealed poor state of laboratory diagnosis of diphtheria in EU countries, which means we are not prepared for the possible outbreaks. This is mostly due to the absence of simple, standard and reliable diagnostic methods. The leading element in the diphtheria laboratory diagnostic approach is a detection of the bacterial toxin. In this regard, it is proposed to develop non-apparatus immunochromatographic strip (ICS) test for diphtheria toxin (DT) indication. In addition a liquid selective medium for the clinical sample cultivation will be designed. A combination of the ICS test and the medium will represent a novel assay for early diphtheria diagnosis. The reagent kit will be commercially produced. The availability of simple, reliable and affordable ICS assay for DT detection will increase the accuracy of diphtheria diagnosis in EU and other countries and reduce the duration of its execution up to 6 hours (instead of 5-7 days as recommended by the WHO manual). The efficient early diphtheria diagnosis will enable timely initiation of anti-diphtheritic treatment that will save lives, prevent the development of complications (heart failure, paralysis), as well as stop the spread of the disease through initiation of preventive measures (vaccination and antibiotic prophylaxis) in case of disease outbreaks.

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The information about "DIFTERIA" are provided by the European Opendata Portal: CORDIS opendata.

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