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DIFTERIA SIGNED

Development of a simple and rapid assay for early diphtheria diagnosis.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DIFTERIA project word cloud

Explore the words cloud of the DIFTERIA project. It provides you a very rough idea of what is the project "DIFTERIA" about.

population    mostly    children    5000    paralysis    substantially    absence    accuracy    200    during    reduce    standard    strip    lives    prepared    recommended    countries    outbreaks    diagnosis    indication    treatment    prevent    cultivation    manual    incidence    circulation    selective    initiation    immunochromatographic    anti    people    clinical    assay    deaths    diphtheritic    ussr    regard    persons    immunological    indigenous    international    unvaccinated    ics    antibiotic    reagent    stop    toxin    poor    instead    diphtheria    commercially    epidemic    liquid    africa    toxigenic    kit    apparatus    poses    preventive    heart    former    combination    vaccination    times    asia    hours    medium    indicate    detection    reports    efficient    bacterial    migrants    disease    diphtheriae    protection    russia    save    spread    complications    declined    days    1990s    laboratory    prophylaxis    revealed    serious    affordable    quality    dt    risk    diagnostic    designed   

Project "DIFTERIA" data sheet

The following table provides information about the project.

Coordinator
SENOVA GESELLSCHAFT FUR BIOWISSENSCHAFT UND TECHNICK MBH 

Organization address
address: INDUSTRIESTR. 8
city: WEIMAR
postcode: 99427
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 174˙806 €
 EC max contribution 174˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SENOVA GESELLSCHAFT FUR BIOWISSENSCHAFT UND TECHNICK MBH DE (WEIMAR) coordinator 174˙806.00

Map

 Project objective

During 1990s, there was an epidemic of diphtheria in Russia and other countries of the former USSR affecting about 200, 000 people with 5000 deaths. Although diphtheria incidence in Russia has declined substantially, recent reports from several EU countries indicate circulation of toxigenic C. diphtheriae among migrants from Asia and Africa as well as children’s deaths among indigenous population. Toxigenic C. diphtheriae poses a serious risk for unvaccinated persons and persons with low level of immunological protection, the number of which in recent times in Europe has increased. The International system of quality control revealed poor state of laboratory diagnosis of diphtheria in EU countries, which means we are not prepared for the possible outbreaks. This is mostly due to the absence of simple, standard and reliable diagnostic methods. The leading element in the diphtheria laboratory diagnostic approach is a detection of the bacterial toxin. In this regard, it is proposed to develop non-apparatus immunochromatographic strip (ICS) test for diphtheria toxin (DT) indication. In addition a liquid selective medium for the clinical sample cultivation will be designed. A combination of the ICS test and the medium will represent a novel assay for early diphtheria diagnosis. The reagent kit will be commercially produced. The availability of simple, reliable and affordable ICS assay for DT detection will increase the accuracy of diphtheria diagnosis in EU and other countries and reduce the duration of its execution up to 6 hours (instead of 5-7 days as recommended by the WHO manual). The efficient early diphtheria diagnosis will enable timely initiation of anti-diphtheritic treatment that will save lives, prevent the development of complications (heart failure, paralysis), as well as stop the spread of the disease through initiation of preventive measures (vaccination and antibiotic prophylaxis) in case of disease outbreaks.

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The information about "DIFTERIA" are provided by the European Opendata Portal: CORDIS opendata.

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