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DIFTERIA SIGNED

Development of a simple and rapid assay for early diphtheria diagnosis.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DIFTERIA project word cloud

Explore the words cloud of the DIFTERIA project. It provides you a very rough idea of what is the project "DIFTERIA" about.

quality    epidemic    toxigenic    reagent    toxin    international    people    apparatus    efficient    incidence    immunological    kit    diphtheria    detection    medium    save    paralysis    vaccination    times    diphtheriae    diphtheritic    protection    prevent    antibiotic    complications    disease    indication    combination    spread    bacterial    unvaccinated    risk    indicate    selective    days    liquid    declined    designed    preventive    diagnostic    reduce    dt    commercially    laboratory    manual    russia    instead    immunochromatographic    former    revealed    ics    persons    countries    accuracy    reports    affordable    assay    absence    initiation    poor    lives    mostly    circulation    prophylaxis    strip    anti    200    5000    recommended    hours    1990s    regard    serious    africa    substantially    migrants    treatment    population    heart    children    cultivation    during    asia    standard    deaths    clinical    outbreaks    diagnosis    prepared    ussr    indigenous    poses    stop   

Project "DIFTERIA" data sheet

The following table provides information about the project.

Coordinator
SENOVA GESELLSCHAFT FUR BIOWISSENSCHAFT UND TECHNICK MBH 

Organization address
address: INDUSTRIESTR. 8
city: WEIMAR
postcode: 99427
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 174˙806 €
 EC max contribution 174˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SENOVA GESELLSCHAFT FUR BIOWISSENSCHAFT UND TECHNICK MBH DE (WEIMAR) coordinator 174˙806.00

Map

 Project objective

During 1990s, there was an epidemic of diphtheria in Russia and other countries of the former USSR affecting about 200, 000 people with 5000 deaths. Although diphtheria incidence in Russia has declined substantially, recent reports from several EU countries indicate circulation of toxigenic C. diphtheriae among migrants from Asia and Africa as well as children’s deaths among indigenous population. Toxigenic C. diphtheriae poses a serious risk for unvaccinated persons and persons with low level of immunological protection, the number of which in recent times in Europe has increased. The International system of quality control revealed poor state of laboratory diagnosis of diphtheria in EU countries, which means we are not prepared for the possible outbreaks. This is mostly due to the absence of simple, standard and reliable diagnostic methods. The leading element in the diphtheria laboratory diagnostic approach is a detection of the bacterial toxin. In this regard, it is proposed to develop non-apparatus immunochromatographic strip (ICS) test for diphtheria toxin (DT) indication. In addition a liquid selective medium for the clinical sample cultivation will be designed. A combination of the ICS test and the medium will represent a novel assay for early diphtheria diagnosis. The reagent kit will be commercially produced. The availability of simple, reliable and affordable ICS assay for DT detection will increase the accuracy of diphtheria diagnosis in EU and other countries and reduce the duration of its execution up to 6 hours (instead of 5-7 days as recommended by the WHO manual). The efficient early diphtheria diagnosis will enable timely initiation of anti-diphtheritic treatment that will save lives, prevent the development of complications (heart failure, paralysis), as well as stop the spread of the disease through initiation of preventive measures (vaccination and antibiotic prophylaxis) in case of disease outbreaks.

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The information about "DIFTERIA" are provided by the European Opendata Portal: CORDIS opendata.

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