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DIFTERIA SIGNED

Development of a simple and rapid assay for early diphtheria diagnosis.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DIFTERIA project word cloud

Explore the words cloud of the DIFTERIA project. It provides you a very rough idea of what is the project "DIFTERIA" about.

prophylaxis    immunological    quality    reduce    heart    efficient    accuracy    countries    standard    mostly    children    dt    absence    toxin    reagent    disease    laboratory    unvaccinated    apparatus    regard    initiation    indicate    outbreaks    assay    diphtheria    complications    designed    clinical    preventive    recommended    circulation    commercially    poor    kit    1990s    substantially    revealed    russia    people    lives    vaccination    antibiotic    days    diagnostic    spread    ics    prevent    paralysis    affordable    indication    instead    ussr    epidemic    international    africa    during    poses    protection    treatment    prepared    former    diagnosis    reports    cultivation    200    incidence    persons    combination    liquid    declined    manual    selective    asia    stop    strip    5000    serious    times    medium    indigenous    detection    diphtheritic    population    diphtheriae    migrants    immunochromatographic    bacterial    anti    deaths    hours    save    toxigenic    risk   

Project "DIFTERIA" data sheet

The following table provides information about the project.

Coordinator
SENOVA GESELLSCHAFT FUR BIOWISSENSCHAFT UND TECHNICK MBH 

Organization address
address: INDUSTRIESTR. 8
city: WEIMAR
postcode: 99427
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 174˙806 €
 EC max contribution 174˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SENOVA GESELLSCHAFT FUR BIOWISSENSCHAFT UND TECHNICK MBH DE (WEIMAR) coordinator 174˙806.00

Map

 Project objective

During 1990s, there was an epidemic of diphtheria in Russia and other countries of the former USSR affecting about 200, 000 people with 5000 deaths. Although diphtheria incidence in Russia has declined substantially, recent reports from several EU countries indicate circulation of toxigenic C. diphtheriae among migrants from Asia and Africa as well as children’s deaths among indigenous population. Toxigenic C. diphtheriae poses a serious risk for unvaccinated persons and persons with low level of immunological protection, the number of which in recent times in Europe has increased. The International system of quality control revealed poor state of laboratory diagnosis of diphtheria in EU countries, which means we are not prepared for the possible outbreaks. This is mostly due to the absence of simple, standard and reliable diagnostic methods. The leading element in the diphtheria laboratory diagnostic approach is a detection of the bacterial toxin. In this regard, it is proposed to develop non-apparatus immunochromatographic strip (ICS) test for diphtheria toxin (DT) indication. In addition a liquid selective medium for the clinical sample cultivation will be designed. A combination of the ICS test and the medium will represent a novel assay for early diphtheria diagnosis. The reagent kit will be commercially produced. The availability of simple, reliable and affordable ICS assay for DT detection will increase the accuracy of diphtheria diagnosis in EU and other countries and reduce the duration of its execution up to 6 hours (instead of 5-7 days as recommended by the WHO manual). The efficient early diphtheria diagnosis will enable timely initiation of anti-diphtheritic treatment that will save lives, prevent the development of complications (heart failure, paralysis), as well as stop the spread of the disease through initiation of preventive measures (vaccination and antibiotic prophylaxis) in case of disease outbreaks.

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