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BABHY-CART SIGNED

Self-Healing Hydrogels for Material-Assisted Cell therapy in Osteoarthritis

Total Cost €

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EC-Contrib. €

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Partnership

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 BABHY-CART project word cloud

Explore the words cloud of the BABHY-CART project. It provides you a very rough idea of what is the project "BABHY-CART" about.

cell    immune    efficient    degeneration    relaxation    location    injectable    models    class    debilitating    healing    injections    reversing    vivo    strategy    mice    therapy    cytoprotection    anti    damaged    assisted    soluble    hold    million    hampered    fate    viscoelastic    preclinical    conventional    mesenchymal    synthetic    appropriate    incurable    translational    efficacy    lasting    inflammation    medical    prevalence    boronic    pressing    immunomodulation    load    intraarticular    secretion    physicochemical    seriously    envisioned    mitigate    painful    stromal    injectability    aging    stopping    morphology    obesity    environment    oa    treat    socioeconomically    synovial    mechanical    context    carefully    age    progress    microenvironment    hydrogel    mscs    promise    self    complementary    matrix    synthesize    regenerative    fast    plays    asc    clinically    limited    encapsulation    adipose    disease    therapies    transplantation    biomaterials    characterizing    date    msc    joints    hydrogels    mimic    exists    stability    europeans    loaded    survival    hyaluronic    acid    strategies    confirmed    trophic    original    osteoarthritis    saline    population    innovative   

Project "BABHY-CART" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE NANTES 

Organization address
address: QUAI DE TOURVILLE 1
city: NANTES CEDEX 1
postcode: 44035
website: www.univ-nantes.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE NANTES FR (NANTES CEDEX 1) coordinator 196˙707.00

Map

 Project objective

Osteoarthritis (OA) is an incurable and painful disease. Over 70 million Europeans are currently affected by OA – a number that is set to increase with aging population and prevalence of obesity. To date, no clinically-efficient therapy exists to treat this socioeconomically debilitating disease. In this context, innovative regenerative therapies for joints are a pressing medical challenge.

Intraarticular mesenchymal stromal cell (MSC) injections hold the great promise of stopping and reversing age-associated inflammation and degeneration of joints by providing the necessary trophic factors to mitigate immune responses. However, translational progress using conventional cell delivery (saline) has been seriously hampered by the limited control over cell survival, location and fate in damaged joints. It is now common knowledge that cell microenvironment plays a crucial role in the success of cell transplantation; and appropriate synthetic matrix design is key to success.

To address challenges in intraarticular MSC-based immunomodulation strategies, we have envisioned an original hydrogel-assisted cell therapy. In this strategy, an injectable hyaluronic acid (HA)-based hydrogel with long-lasting viscoelastic properties will allow MSC encapsulation and cytoprotection, ensuring the production of anti-OA soluble factors in vivo. To best mimic synovial environment and support MSCs in vivo, we will synthesize a novel boronic acid-based, self-healing HA hydrogel with unique properties of injectability, stability and fast relaxation under mechanical load.

After carefully characterizing the physicochemical properties of this new class of biomaterials, we will investigate the effects of cell encapsulation on adipose stromal cell (ASC) survival, morphology and factor secretion. Then, the preclinical efficacy of intraarticular injections of cell-loaded, self-healing hydrogels will be confirmed in two complementary OA mice models.

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The information about "BABHY-CART" are provided by the European Opendata Portal: CORDIS opendata.

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