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BABHY-CART SIGNED

Self-Healing Hydrogels for Material-Assisted Cell therapy in Osteoarthritis

Total Cost €

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EC-Contrib. €

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Partnership

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 BABHY-CART project word cloud

Explore the words cloud of the BABHY-CART project. It provides you a very rough idea of what is the project "BABHY-CART" about.

obesity    efficacy    oa    physicochemical    mitigate    age    confirmed    immunomodulation    hold    mice    preclinical    pressing    morphology    encapsulation    degeneration    envisioned    date    loaded    treat    intraarticular    hydrogels    therapies    efficient    fate    msc    location    context    prevalence    anti    adipose    biomaterials    medical    innovative    class    joints    clinically    million    plays    disease    synthesize    self    characterizing    exists    synthetic    mimic    appropriate    survival    therapy    acid    injectability    limited    hyaluronic    socioeconomically    incurable    mechanical    asc    load    strategy    original    aging    fast    trophic    translational    cytoprotection    injectable    osteoarthritis    conventional    injections    regenerative    debilitating    matrix    immune    population    stromal    damaged    environment    seriously    assisted    soluble    boronic    complementary    lasting    synovial    mscs    saline    mesenchymal    microenvironment    viscoelastic    relaxation    stability    vivo    secretion    cell    painful    transplantation    healing    strategies    promise    europeans    hydrogel    reversing    hampered    inflammation    models    carefully    progress    stopping   

Project "BABHY-CART" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE NANTES 

Organization address
address: QUAI DE TOURVILLE 1
city: NANTES CEDEX 1
postcode: 44035
website: www.univ-nantes.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE NANTES FR (NANTES CEDEX 1) coordinator 196˙707.00

Map

 Project objective

Osteoarthritis (OA) is an incurable and painful disease. Over 70 million Europeans are currently affected by OA – a number that is set to increase with aging population and prevalence of obesity. To date, no clinically-efficient therapy exists to treat this socioeconomically debilitating disease. In this context, innovative regenerative therapies for joints are a pressing medical challenge.

Intraarticular mesenchymal stromal cell (MSC) injections hold the great promise of stopping and reversing age-associated inflammation and degeneration of joints by providing the necessary trophic factors to mitigate immune responses. However, translational progress using conventional cell delivery (saline) has been seriously hampered by the limited control over cell survival, location and fate in damaged joints. It is now common knowledge that cell microenvironment plays a crucial role in the success of cell transplantation; and appropriate synthetic matrix design is key to success.

To address challenges in intraarticular MSC-based immunomodulation strategies, we have envisioned an original hydrogel-assisted cell therapy. In this strategy, an injectable hyaluronic acid (HA)-based hydrogel with long-lasting viscoelastic properties will allow MSC encapsulation and cytoprotection, ensuring the production of anti-OA soluble factors in vivo. To best mimic synovial environment and support MSCs in vivo, we will synthesize a novel boronic acid-based, self-healing HA hydrogel with unique properties of injectability, stability and fast relaxation under mechanical load.

After carefully characterizing the physicochemical properties of this new class of biomaterials, we will investigate the effects of cell encapsulation on adipose stromal cell (ASC) survival, morphology and factor secretion. Then, the preclinical efficacy of intraarticular injections of cell-loaded, self-healing hydrogels will be confirmed in two complementary OA mice models.

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The information about "BABHY-CART" are provided by the European Opendata Portal: CORDIS opendata.

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