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BABHY-CART SIGNED

Self-Healing Hydrogels for Material-Assisted Cell therapy in Osteoarthritis

Total Cost €

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EC-Contrib. €

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Partnership

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 BABHY-CART project word cloud

Explore the words cloud of the BABHY-CART project. It provides you a very rough idea of what is the project "BABHY-CART" about.

injections    loaded    characterizing    disease    encapsulation    context    physicochemical    intraarticular    obesity    hydrogels    aging    morphology    stability    strategies    conventional    europeans    cell    confirmed    mimic    fast    injectability    original    synthesize    joints    envisioned    acid    anti    pressing    synovial    boronic    saline    plays    trophic    mice    million    medical    efficacy    injectable    date    population    prevalence    microenvironment    asc    limited    immune    fate    exists    regenerative    survival    matrix    age    painful    relaxation    models    appropriate    self    hampered    strategy    soluble    mscs    lasting    innovative    adipose    oa    progress    efficient    hyaluronic    class    translational    immunomodulation    hold    carefully    mechanical    seriously    treat    location    vivo    reversing    stopping    assisted    therapy    preclinical    hydrogel    biomaterials    degeneration    debilitating    healing    therapies    load    synthetic    environment    mitigate    secretion    stromal    cytoprotection    inflammation    msc    incurable    clinically    socioeconomically    transplantation    promise    viscoelastic    complementary    mesenchymal    osteoarthritis    damaged   

Project "BABHY-CART" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE NANTES 

Organization address
address: QUAI DE TOURVILLE 1
city: NANTES CEDEX 1
postcode: 44035
website: www.univ-nantes.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE NANTES FR (NANTES CEDEX 1) coordinator 196˙707.00

Map

 Project objective

Osteoarthritis (OA) is an incurable and painful disease. Over 70 million Europeans are currently affected by OA – a number that is set to increase with aging population and prevalence of obesity. To date, no clinically-efficient therapy exists to treat this socioeconomically debilitating disease. In this context, innovative regenerative therapies for joints are a pressing medical challenge.

Intraarticular mesenchymal stromal cell (MSC) injections hold the great promise of stopping and reversing age-associated inflammation and degeneration of joints by providing the necessary trophic factors to mitigate immune responses. However, translational progress using conventional cell delivery (saline) has been seriously hampered by the limited control over cell survival, location and fate in damaged joints. It is now common knowledge that cell microenvironment plays a crucial role in the success of cell transplantation; and appropriate synthetic matrix design is key to success.

To address challenges in intraarticular MSC-based immunomodulation strategies, we have envisioned an original hydrogel-assisted cell therapy. In this strategy, an injectable hyaluronic acid (HA)-based hydrogel with long-lasting viscoelastic properties will allow MSC encapsulation and cytoprotection, ensuring the production of anti-OA soluble factors in vivo. To best mimic synovial environment and support MSCs in vivo, we will synthesize a novel boronic acid-based, self-healing HA hydrogel with unique properties of injectability, stability and fast relaxation under mechanical load.

After carefully characterizing the physicochemical properties of this new class of biomaterials, we will investigate the effects of cell encapsulation on adipose stromal cell (ASC) survival, morphology and factor secretion. Then, the preclinical efficacy of intraarticular injections of cell-loaded, self-healing hydrogels will be confirmed in two complementary OA mice models.

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The information about "BABHY-CART" are provided by the European Opendata Portal: CORDIS opendata.

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