Opendata, web and dolomites


Development of Collagenase Polymeric nanocapsules as Therapeutics

Total Cost €


EC-Contrib. €






 DECOMPACT project word cloud

Explore the words cloud of the DECOMPACT project. It provides you a very rough idea of what is the project "DECOMPACT" about.

digestion    external    human    cross    embraces    nanodevice    considering    therapeutics    2015    verdi    form    release    labile    housed    nanodevices    matrices    treatment    benefits    library    population    protect    evaluation    social    society    place    conventional    body    irradiation    situ    grant    proteolytic    induce    decompact    accumulation    commercialization    fibers    vitro    immunosuppressant    scleroderma    fibrotic    treatments    nature    nanocapsules    erc    linkers    3d    skin    medical    expert    combine    supposes    purposes    incidence    adg    team    digest    plan    collagenase    innovation    sensitive    enzyme    diseases    obtain    economic    mouse    nanotechnology    vivo    cells    employing    proof    polymeric    responsive    professionals    collagen    inflammatory    exposition    market    methodology    compromises    specialized    context    immunosuppressive    synthesis    trigger    insults    doctors    respect    anti    694160    degrade    uva    stimuli    abnormal    disease    enzymes    model    capacity   

Project "DECOMPACT" data sheet

The following table provides information about the project.


Organization address
city: MADRID
postcode: 28040

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 149˙611 €
 EC max contribution 149˙611 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2020-10-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

“Developments of Collagenase Polymeric nanocapsules as Therapeutics (DECOMPACT)”. The goal of this proof of concept project is the development and commercialization of a novel treatment to scleroderma. Scleroderma is a fibrotic disease with a significant incidence in the population and is characterized by an abnormal accumulation of collagen. Treatment of this disease involves the use of proteolytic enzymes, as collagenase, able to digest collagen fibers. However, the labile nature of collagenase compromises its activity in the human body. DECOMPACT purposes the development of polymeric-collagenase nanocapsules that protect the housed enzymes against external insults and are able to release them by UVA irradiation exposition. UVA irradiation has been selected as trigger release stimuli due to its capacity to induce both anti-inflammatory, immunosuppressive effects and to enhance collagenase production in situ. These novel stimuli-responsive nanodevices would combine the ability of the proteolytic enzyme to degrade collagen with the immunosuppressant and anti-inflammatory effects of UVA. The methodology to obtain the system is based on previous results achieved in the context of the Advance Grant ERC-2015-AdG Proposal No.694160, VERDI. The work plan involves the synthesis of a library of UVA-sensitive cross-linkers which form the nanodevice, studies of UVA-responsive and evaluation of collagen digestion ability both in vitro employing 3D collagen matrices with skin cells embedded and in vivo using a scleroderma mouse model. This project supposes an important innovation respect to conventional treatments and could provide important social-economic benefits to the society. Finally, DECOMPACT embraces a work plan considering the commercialization steps which are required in order to place this technology in the market. The work team involved in this project includes specialized professionals in nanotechnology and medical doctors expert in fibrotic diseases.

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The information about "DECOMPACT" are provided by the European Opendata Portal: CORDIS opendata.

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