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DECOMPACT SIGNED

Development of Collagenase Polymeric nanocapsules as Therapeutics

Total Cost €

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EC-Contrib. €

0

Partnership

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 DECOMPACT project word cloud

Explore the words cloud of the DECOMPACT project. It provides you a very rough idea of what is the project "DECOMPACT" about.

methodology    synthesis    model    proof    social    inflammatory    exposition    stimuli    matrices    expert    context    degrade    respect    verdi    nature    nanocapsules    mouse    abnormal    disease    fibers    nanodevices    polymeric    labile    situ    compromises    digest    society    fibrotic    library    cells    uva    therapeutics    insults    commercialization    external    cross    purposes    proteolytic    skin    grant    enzyme    plan    irradiation    evaluation    vivo    conventional    trigger    specialized    supposes    immunosuppressive    embraces    housed    medical    responsive    enzymes    human    diseases    scleroderma    professionals    694160    collagen    market    adg    erc    2015    incidence    form    economic    treatments    protect    decompact    obtain    capacity    place    benefits    3d    linkers    population    employing    innovation    doctors    release    nanotechnology    body    nanodevice    anti    sensitive    immunosuppressant    team    treatment    collagenase    combine    accumulation    vitro    considering    induce    digestion   

Project "DECOMPACT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD COMPLUTENSE DE MADRID 

Organization address
address: AVENIDA DE SENECA 2
city: MADRID
postcode: 28040
website: http://www.ucm.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 149˙611 €
 EC max contribution 149˙611 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD COMPLUTENSE DE MADRID ES (MADRID) coordinator 149˙611.00

Map

 Project objective

“Developments of Collagenase Polymeric nanocapsules as Therapeutics (DECOMPACT)”. The goal of this proof of concept project is the development and commercialization of a novel treatment to scleroderma. Scleroderma is a fibrotic disease with a significant incidence in the population and is characterized by an abnormal accumulation of collagen. Treatment of this disease involves the use of proteolytic enzymes, as collagenase, able to digest collagen fibers. However, the labile nature of collagenase compromises its activity in the human body. DECOMPACT purposes the development of polymeric-collagenase nanocapsules that protect the housed enzymes against external insults and are able to release them by UVA irradiation exposition. UVA irradiation has been selected as trigger release stimuli due to its capacity to induce both anti-inflammatory, immunosuppressive effects and to enhance collagenase production in situ. These novel stimuli-responsive nanodevices would combine the ability of the proteolytic enzyme to degrade collagen with the immunosuppressant and anti-inflammatory effects of UVA. The methodology to obtain the system is based on previous results achieved in the context of the Advance Grant ERC-2015-AdG Proposal No.694160, VERDI. The work plan involves the synthesis of a library of UVA-sensitive cross-linkers which form the nanodevice, studies of UVA-responsive and evaluation of collagen digestion ability both in vitro employing 3D collagen matrices with skin cells embedded and in vivo using a scleroderma mouse model. This project supposes an important innovation respect to conventional treatments and could provide important social-economic benefits to the society. Finally, DECOMPACT embraces a work plan considering the commercialization steps which are required in order to place this technology in the market. The work team involved in this project includes specialized professionals in nanotechnology and medical doctors expert in fibrotic diseases.

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The information about "DECOMPACT" are provided by the European Opendata Portal: CORDIS opendata.

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