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DECOMPACT SIGNED

Development of Collagenase Polymeric nanocapsules as Therapeutics

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 DECOMPACT project word cloud

Explore the words cloud of the DECOMPACT project. It provides you a very rough idea of what is the project "DECOMPACT" about.

vivo    methodology    cross    social    diseases    skin    protect    erc    collagenase    plan    professionals    exposition    human    accumulation    nature    incidence    place    mouse    considering    stimuli    population    medical    evaluation    digestion    insults    disease    sensitive    benefits    form    polymeric    synthesis    labile    doctors    economic    enzyme    society    library    collagen    market    verdi    vitro    anti    3d    nanotechnology    grant    adg    model    irradiation    inflammatory    external    responsive    embraces    compromises    immunosuppressant    housed    conventional    release    supposes    694160    context    employing    team    linkers    combine    fibrotic    scleroderma    proof    innovation    obtain    respect    fibers    capacity    degrade    situ    specialized    nanodevice    uva    matrices    nanodevices    digest    body    proteolytic    expert    treatment    abnormal    induce    commercialization    trigger    treatments    therapeutics    immunosuppressive    nanocapsules    cells    purposes    decompact    2015    enzymes   

Project "DECOMPACT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD COMPLUTENSE DE MADRID 

Organization address
address: AVENIDA DE SENECA 2
city: MADRID
postcode: 28040
website: http://www.ucm.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 149˙611 €
 EC max contribution 149˙611 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD COMPLUTENSE DE MADRID ES (MADRID) coordinator 149˙611.00

Map

 Project objective

“Developments of Collagenase Polymeric nanocapsules as Therapeutics (DECOMPACT)”. The goal of this proof of concept project is the development and commercialization of a novel treatment to scleroderma. Scleroderma is a fibrotic disease with a significant incidence in the population and is characterized by an abnormal accumulation of collagen. Treatment of this disease involves the use of proteolytic enzymes, as collagenase, able to digest collagen fibers. However, the labile nature of collagenase compromises its activity in the human body. DECOMPACT purposes the development of polymeric-collagenase nanocapsules that protect the housed enzymes against external insults and are able to release them by UVA irradiation exposition. UVA irradiation has been selected as trigger release stimuli due to its capacity to induce both anti-inflammatory, immunosuppressive effects and to enhance collagenase production in situ. These novel stimuli-responsive nanodevices would combine the ability of the proteolytic enzyme to degrade collagen with the immunosuppressant and anti-inflammatory effects of UVA. The methodology to obtain the system is based on previous results achieved in the context of the Advance Grant ERC-2015-AdG Proposal No.694160, VERDI. The work plan involves the synthesis of a library of UVA-sensitive cross-linkers which form the nanodevice, studies of UVA-responsive and evaluation of collagen digestion ability both in vitro employing 3D collagen matrices with skin cells embedded and in vivo using a scleroderma mouse model. This project supposes an important innovation respect to conventional treatments and could provide important social-economic benefits to the society. Finally, DECOMPACT embraces a work plan considering the commercialization steps which are required in order to place this technology in the market. The work team involved in this project includes specialized professionals in nanotechnology and medical doctors expert in fibrotic diseases.

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The information about "DECOMPACT" are provided by the European Opendata Portal: CORDIS opendata.

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