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NEUROFLIES SIGNED

Drosophila sechellia: a novel model to investigate nervous system and behavioral evolution

Total Cost €

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EC-Contrib. €

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Partnership

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 NEUROFLIES project word cloud

Explore the words cloud of the NEUROFLIES project. It provides you a very rough idea of what is the project "NEUROFLIES" about.

feeding    maintenance    insights    neuroanatomical    island    animals    adaption    mechanisms    toolkit    genotypes    generation    nervous    neuro    evolutionary    behaviors    functional    basis    reveal    fundamental    variation    origins    neural    evolution    recombination    model    powerful    diversification    multiple    simulans    expression    unknown    mapping    generalist    fruit    establishment    points    function    closely    cousins    cosmopolitan    anatomical    behavioral    molecular    physiological    offers    neurogenetic    select    species    distinctions    host    endemic    deep    diverse    allele    neuroanatomy    entry    neuronal    differences    retains    investment    underlying    superficial    extraordinarily    genetic    global    significance    systematic    ecological    manipulations    sechellia    sole    genomic    interspecific    desired    phenomics    resolution    morinda    causal    circuits    swap    reagents    drosophila    similarity    breeding    niche    relate    inform    how    morphological    melanogaster    neuroscience   

Project "NEUROFLIES" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LAUSANNE 

Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
city: LAUSANNE
postcode: 1015
website: www.unil.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙327˙547 €
 EC max contribution 2˙327˙547 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 2˙327˙547.00

Map

 Project objective

How animals’ extraordinarily diverse behaviors have evolved is unknown. Relating interspecific behavioral differences to anatomical or physiological distinctions in neural circuits, and causal genetic variation, offers a powerful approach to inform how nervous systems develop, function and change.

Understanding behavioral and nervous system evolution requires deep investment in select species. We propose to establish a new model neurogenetic system: Drosophila sechellia, an island endemic that is closely related to D. melanogaster and D. simulans. While D. sechellia retains global genomic and superficial morphological similarity to its cosmopolitan generalist cousins, this species has adapted to a unique ecological niche, using Morinda fruit as a sole host for feeding and breeding. The project has three aims:

Aim 1. Establishment of a D. sechellia (neuro)genetic toolkit: we will build essential genetic reagents for generation and maintenance of animals of desired genotypes, for neurogenetic manipulations, and for recombination mapping-based approaches.

Aim 2. Behavioral, neuroanatomical and molecular phenomics: systematic comparison of D. sechellia, D. simulans and D. melanogaster for their behaviors, their neuroanatomy and their neuro-molecular expression properties will reveal how D. sechellia has adapted to its niche, and will provide multiple entry-points to relate molecular, neuronal and behavioral differences between these species.

Aim 3. Defining the genetic basis and functional significance of a neuronal adaptation in D. sechellia: through high-resolution mapping and allele swap approaches, we will identify the causal genetic changes underlying a neural adaption in D. sechellia, and its physiological and behavioral significance.

This project will establish a powerful new model system for evolutionary neuroscience (and many other fields) and provide fundamental insights into the origins and mechanisms of nervous system and behavioral diversification.

 Deliverables

List of deliverables.
Data Management Plan Open Research Data Pilot 2020-02-12 16:52:54

Take a look to the deliverables list in detail:  detailed list of NEUROFLIES deliverables.

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The information about "NEUROFLIES" are provided by the European Opendata Portal: CORDIS opendata.

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