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Drosophila sechellia: a novel model to investigate nervous system and behavioral evolution

Total Cost €


EC-Contrib. €






 NEUROFLIES project word cloud

Explore the words cloud of the NEUROFLIES project. It provides you a very rough idea of what is the project "NEUROFLIES" about.

functional    expression    maintenance    genotypes    underlying    endemic    melanogaster    resolution    neuroanatomical    genetic    cousins    simulans    anatomical    neurogenetic    superficial    deep    behavioral    model    origins    circuits    allele    morinda    manipulations    entry    neural    morphological    function    closely    swap    powerful    investment    significance    cosmopolitan    behaviors    phenomics    systematic    generalist    variation    fundamental    neuro    distinctions    ecological    evolution    sechellia    basis    similarity    interspecific    neuroanatomy    genomic    insights    how    reagents    recombination    physiological    island    neuroscience    offers    toolkit    evolutionary    unknown    extraordinarily    nervous    adaption    breeding    diverse    feeding    mechanisms    relate    differences    desired    causal    mapping    sole    select    global    species    retains    points    animals    host    inform    niche    diversification    generation    multiple    reveal    molecular    establishment    neuronal    drosophila    fruit   

Project "NEUROFLIES" data sheet

The following table provides information about the project.


Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
postcode: 1015

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙327˙547 €
 EC max contribution 2˙327˙547 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 2˙327˙547.00


 Project objective

How animals’ extraordinarily diverse behaviors have evolved is unknown. Relating interspecific behavioral differences to anatomical or physiological distinctions in neural circuits, and causal genetic variation, offers a powerful approach to inform how nervous systems develop, function and change.

Understanding behavioral and nervous system evolution requires deep investment in select species. We propose to establish a new model neurogenetic system: Drosophila sechellia, an island endemic that is closely related to D. melanogaster and D. simulans. While D. sechellia retains global genomic and superficial morphological similarity to its cosmopolitan generalist cousins, this species has adapted to a unique ecological niche, using Morinda fruit as a sole host for feeding and breeding. The project has three aims:

Aim 1. Establishment of a D. sechellia (neuro)genetic toolkit: we will build essential genetic reagents for generation and maintenance of animals of desired genotypes, for neurogenetic manipulations, and for recombination mapping-based approaches.

Aim 2. Behavioral, neuroanatomical and molecular phenomics: systematic comparison of D. sechellia, D. simulans and D. melanogaster for their behaviors, their neuroanatomy and their neuro-molecular expression properties will reveal how D. sechellia has adapted to its niche, and will provide multiple entry-points to relate molecular, neuronal and behavioral differences between these species.

Aim 3. Defining the genetic basis and functional significance of a neuronal adaptation in D. sechellia: through high-resolution mapping and allele swap approaches, we will identify the causal genetic changes underlying a neural adaption in D. sechellia, and its physiological and behavioral significance.

This project will establish a powerful new model system for evolutionary neuroscience (and many other fields) and provide fundamental insights into the origins and mechanisms of nervous system and behavioral diversification.


List of deliverables.
Data Management Plan Open Research Data Pilot 2020-02-12 16:52:54

Take a look to the deliverables list in detail:  detailed list of NEUROFLIES deliverables.

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The information about "NEUROFLIES" are provided by the European Opendata Portal: CORDIS opendata.

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