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NEUROFLIES SIGNED

Drosophila sechellia: a novel model to investigate nervous system and behavioral evolution

Total Cost €

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EC-Contrib. €

0

Partnership

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 NEUROFLIES project word cloud

Explore the words cloud of the NEUROFLIES project. It provides you a very rough idea of what is the project "NEUROFLIES" about.

distinctions    breeding    superficial    diverse    genomic    recombination    closely    reveal    multiple    global    offers    underlying    endemic    relate    entry    basis    molecular    differences    deep    interspecific    model    diversification    similarity    neuronal    genetic    generalist    generation    extraordinarily    investment    systematic    cousins    island    origins    causal    melanogaster    function    neuroscience    neurogenetic    behavioral    phenomics    neuroanatomical    resolution    circuits    how    retains    significance    niche    neuro    unknown    nervous    fruit    neuroanatomy    simulans    sole    neural    drosophila    toolkit    functional    evolutionary    mechanisms    establishment    physiological    cosmopolitan    maintenance    swap    animals    variation    genotypes    host    reagents    insights    ecological    allele    sechellia    species    select    desired    adaption    manipulations    expression    powerful    mapping    behaviors    morphological    morinda    evolution    inform    points    anatomical    fundamental    feeding   

Project "NEUROFLIES" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LAUSANNE 

Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
city: LAUSANNE
postcode: 1015
website: www.unil.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙327˙547 €
 EC max contribution 2˙327˙547 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 2˙327˙547.00

Map

 Project objective

How animals’ extraordinarily diverse behaviors have evolved is unknown. Relating interspecific behavioral differences to anatomical or physiological distinctions in neural circuits, and causal genetic variation, offers a powerful approach to inform how nervous systems develop, function and change.

Understanding behavioral and nervous system evolution requires deep investment in select species. We propose to establish a new model neurogenetic system: Drosophila sechellia, an island endemic that is closely related to D. melanogaster and D. simulans. While D. sechellia retains global genomic and superficial morphological similarity to its cosmopolitan generalist cousins, this species has adapted to a unique ecological niche, using Morinda fruit as a sole host for feeding and breeding. The project has three aims:

Aim 1. Establishment of a D. sechellia (neuro)genetic toolkit: we will build essential genetic reagents for generation and maintenance of animals of desired genotypes, for neurogenetic manipulations, and for recombination mapping-based approaches.

Aim 2. Behavioral, neuroanatomical and molecular phenomics: systematic comparison of D. sechellia, D. simulans and D. melanogaster for their behaviors, their neuroanatomy and their neuro-molecular expression properties will reveal how D. sechellia has adapted to its niche, and will provide multiple entry-points to relate molecular, neuronal and behavioral differences between these species.

Aim 3. Defining the genetic basis and functional significance of a neuronal adaptation in D. sechellia: through high-resolution mapping and allele swap approaches, we will identify the causal genetic changes underlying a neural adaption in D. sechellia, and its physiological and behavioral significance.

This project will establish a powerful new model system for evolutionary neuroscience (and many other fields) and provide fundamental insights into the origins and mechanisms of nervous system and behavioral diversification.

 Deliverables

List of deliverables.
Data Management Plan Open Research Data Pilot 2020-02-12 16:52:54

Take a look to the deliverables list in detail:  detailed list of NEUROFLIES deliverables.

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The information about "NEUROFLIES" are provided by the European Opendata Portal: CORDIS opendata.

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