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POPMET SIGNED

Large-scale identification of secondary metabolites, metabolic pathways and their genes in the model tree poplar

Total Cost €

EC-Contrib. €

Partnership

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POPMET project word cloud

Explore the words cloud of the POPMET project. It provides you a very rough idea of what is the project "POPMET" about.

cas9 rare shape defective underpinned functions re wood assays enzymes lay innovative foundation conversions identities time unknown metabolites identification gene true crossing tool progress living deep predict functional genes resolving bark gap systematically made molecular biology abundance association subsequently leaves biosynthetic snps purify crispr poplar metabolomics predicted genome lab metabolite steady gwas structure effort discovery industrial difficult alleles species content sequence scarce trees encoding informatics natural cspp experimental hindering sequenced obtaining combination editing producing either population crop enzyme data model 750 biomass impedes complementary secondary structures poplars heterozygous metabolic combined lack characterization genetic structural woody

Project "POPMET" data sheet

The following table provides information about the project.

Coordinator	VIB VZW Organization address address: RIJVISSCHESTRAAT 120 city: ZWIJNAARDE - GENT postcode: 9052 website: www.vib.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Total cost	2˙499˙251 €
EC max contribution	2˙499˙251 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2018-ADG
Funding Scheme	ERC-ADG
Starting year	2019
Duration (year-month-day)	from 2019-07-01 to 2024-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	VIB VZW VIB VZW Organization address address: RIJVISSCHESTRAAT 120 city: ZWIJNAARDE - GENT postcode: 9052 website: www.vib.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ZWIJNAARDE - GENT)	coordinator	2˙499˙251.00

Map

Project objective

Poplar is an important woody biomass crop and at the same time the model of choice for molecular research in trees. Although there is steady progress in resolving the functions of unknown genes, the identities of most secondary metabolites in poplar remain unknown. The lack of metabolite identities in experimental systems is a true gap in information content, and impedes obtaining deep insight into the complex biology of living systems. The main reason is that metabolites are difficult to purify because of their low abundance, hindering their structural characterization and the discovery of their biosynthetic pathways. In this project, we will use CSPP, an innovative method recently developed in my lab, to systematically predict the structures of metabolites along with their biosynthetic pathways in poplar wood, bark and leaves. This CSPP method is based on a combination of metabolomics and informatics. In a next step, the CSPP tool will be combined with two complementary genetic approaches based on re-sequence data from 750 poplar trees to identify the genes encoding the enzymes in the predicted pathways. Genome Wide Association Studies (GWAS) will be made to identify SNPs in the genes involved in the metabolic conversions. Subsequently, rare defective alleles will be identified for these genes in the sequenced population. Genes identified by both approaches will then be further studied either by crossing natural poplars that are heterozygous for the defective alleles, or by CRISPR/Cas9-based gene editing in poplar. The functional studies will be further underpinned by enzyme assays. Given our scarce knowledge on the structure of most secondary metabolites and their metabolic pathways in poplar, this large-scale identification effort will lay the foundation for systems biology research in this species, and will shape opportunities to further develop poplar as an industrial wood-producing crop.

Deliverables

List of deliverables.
data management plan	Open Research Data Pilot	2020-02-12 17:34:21

Take a look to the deliverables list in detail: detailed list of POPMET deliverables.

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The information about "POPMET" are provided by the European Opendata Portal: CORDIS opendata.