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POPMET SIGNED

Large-scale identification of secondary metabolites, metabolic pathways and their genes in the model tree poplar

Total Cost €

0

EC-Contrib. €

0

Partnership

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 POPMET project word cloud

Explore the words cloud of the POPMET project. It provides you a very rough idea of what is the project "POPMET" about.

experimental    rare    subsequently    resolving    genome    enzymes    hindering    heterozygous    encoding    metabolite    characterization    impedes    abundance    poplar    population    underpinned    true    assays    model    obtaining    metabolites    shape    producing    difficult    defective    cas9    industrial    association    re    genetic    crispr    sequence    lack    lab    time    content    identities    progress    functional    enzyme    identification    foundation    innovative    wood    cspp    made    lay    effort    leaves    biology    systematically    alleles    steady    snps    data    complementary    purify    informatics    living    structure    structures    tool    molecular    discovery    crop    secondary    either    scarce    metabolomics    bark    poplars    sequenced    conversions    species    trees    combined    natural    genes    unknown    predicted    combination    woody    gwas    structural    functions    gap    biomass    gene    750    metabolic    biosynthetic    crossing    deep    editing    predict   

Project "POPMET" data sheet

The following table provides information about the project.

Coordinator
VIB VZW 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 2˙499˙251 €
 EC max contribution 2˙499˙251 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2024-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 2˙499˙251.00

Map

 Project objective

Poplar is an important woody biomass crop and at the same time the model of choice for molecular research in trees. Although there is steady progress in resolving the functions of unknown genes, the identities of most secondary metabolites in poplar remain unknown. The lack of metabolite identities in experimental systems is a true gap in information content, and impedes obtaining deep insight into the complex biology of living systems. The main reason is that metabolites are difficult to purify because of their low abundance, hindering their structural characterization and the discovery of their biosynthetic pathways. In this project, we will use CSPP, an innovative method recently developed in my lab, to systematically predict the structures of metabolites along with their biosynthetic pathways in poplar wood, bark and leaves. This CSPP method is based on a combination of metabolomics and informatics. In a next step, the CSPP tool will be combined with two complementary genetic approaches based on re-sequence data from 750 poplar trees to identify the genes encoding the enzymes in the predicted pathways. Genome Wide Association Studies (GWAS) will be made to identify SNPs in the genes involved in the metabolic conversions. Subsequently, rare defective alleles will be identified for these genes in the sequenced population. Genes identified by both approaches will then be further studied either by crossing natural poplars that are heterozygous for the defective alleles, or by CRISPR/Cas9-based gene editing in poplar. The functional studies will be further underpinned by enzyme assays. Given our scarce knowledge on the structure of most secondary metabolites and their metabolic pathways in poplar, this large-scale identification effort will lay the foundation for systems biology research in this species, and will shape opportunities to further develop poplar as an industrial wood-producing crop.

 Deliverables

List of deliverables.
data management plan Open Research Data Pilot 2020-02-12 17:34:21

Take a look to the deliverables list in detail:  detailed list of POPMET deliverables.

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The information about "POPMET" are provided by the European Opendata Portal: CORDIS opendata.

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