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Finding VENomS SIGNED

Venom Evolution in Nemerteans: Connecting Functional Morphology, Gene Expression and Proteome through Spatial Omics

Total Cost €

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EC-Contrib. €

0

Partnership

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 Finding VENomS project word cloud

Explore the words cloud of the Finding VENomS project. It provides you a very rough idea of what is the project "Finding VENomS" about.

light    dge    functional    pharmaceuticals    nature    st    discovery    animal    rna    despite    degree    blue    maldi    complexity    tools    phyla    nemertea    bioactive    differential    compounds    toxin    underlying    ms    evolutionary    techniques    omics    defence    transcriptomics    revealing    seq    drug    morphology    competition    defense    tem    assist    ims    worm    transmission    independently    poorly    mass    tandem    organisms    views    sequencing    uncover    electron    area    diversity    predation    taxa    molecular    analytical    model    diverse    integrative    advancements    additionally    secretions    expression    scanning    venoms    combining    invertebrates    understudied    integrate    leads    convergence    adaptations    true    proteogenomics    biochemical    ribbon    sem    shed    active    predators    evolution    bio    proteomics    spectrometry    spatial    venomics    data    microscopy    biotechnological    venomous    worms    structure    venom    genetic    toxins    gene    composition   

Project "Finding VENomS" data sheet

The following table provides information about the project.

Coordinator
NATURAL HISTORY MUSEUM 

Organization address
address: CROMWELL ROAD
city: LONDON
postcode: SW7 5BD
website: http://www.nhm.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-10-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATURAL HISTORY MUSEUM UK (LONDON) coordinator 224˙933.00

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 Project objective

Animal venoms are key adaptations that have evolved independently in many taxa to assist in defence, predation and competition. Venoms are some of the most complex biochemical secretions known in nature, but despite this complexity, there is a high degree of convergence in toxin structure and targets, making venomous organisms great model systems to investigate areas as diverse as molecular evolution, functional convergence and drug discovery. However, the processes underlying toxin and venom evolution remain poorly understood, particularly in invertebrates. With recent advancements in sequencing and analytical techniques these neglected taxa are being increasingly investigated, revealing a high genetic and functional diversity of venom compounds and challenging traditional views about venom evolution. Still, many phyla such as ribbon worms (Nemertea), active predators that use toxins for defense and predation, remain understudied. This project aims to investigate venom evolution in Nemertea using an integrative evolutionary venomics approach. I propose to use a transcriptomics-proteomics approach referred to as proteogenomics, combining RNA-seq differential gene expression analysis (DGE) and tandem mass spectrometry-based proteomics (MS/MS) to determine venom composition, and integrate these data with expression and functional morphology data derived from spatial omics, both spatial transcriptomics (ST) and spatial proteomics (MALDI-IMS), transmission and scanning electron microscopy (TEM and SEM). This will advance our understanding of ribbon worm venom systems, and shed new light into the true diversity of animal venoms and their evolution. Additionally, this research will likely uncover novel bioactive compounds, with great potential as drug leads and biotechnological tools, making this project’s findings highly relevant to the H2020 focus area Blue Growth objective of developing new bio-based products, including pharmaceuticals.

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The information about "FINDING VENOMS" are provided by the European Opendata Portal: CORDIS opendata.

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