Opendata, web and dolomites

Finding VENomS SIGNED

Venom Evolution in Nemerteans: Connecting Functional Morphology, Gene Expression and Proteome through Spatial Omics

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Finding VENomS project word cloud

Explore the words cloud of the Finding VENomS project. It provides you a very rough idea of what is the project "Finding VENomS" about.

maldi    discovery    understudied    st    structure    true    integrate    secretions    advancements    microscopy    light    expression    active    transmission    ms    morphology    biochemical    sem    leads    invertebrates    assist    seq    composition    uncover    toxins    analytical    rna    complexity    electron    adaptations    taxa    shed    spectrometry    area    data    combining    organisms    venomics    biotechnological    diverse    bio    defence    molecular    convergence    degree    bioactive    independently    ribbon    drug    proteomics    venomous    animal    despite    nemertea    venoms    omics    views    proteogenomics    worm    venom    scanning    poorly    defense    phyla    additionally    tandem    revealing    predation    compounds    predators    differential    pharmaceuticals    nature    dge    diversity    integrative    worms    competition    functional    techniques    tem    underlying    sequencing    gene    mass    evolutionary    tools    evolution    genetic    ims    blue    toxin    model    spatial    transcriptomics   

Project "Finding VENomS" data sheet

The following table provides information about the project.

Coordinator
NATURAL HISTORY MUSEUM 

Organization address
address: CROMWELL ROAD
city: LONDON
postcode: SW7 5BD
website: http://www.nhm.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-10-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATURAL HISTORY MUSEUM UK (LONDON) coordinator 224˙933.00

Map

 Project objective

Animal venoms are key adaptations that have evolved independently in many taxa to assist in defence, predation and competition. Venoms are some of the most complex biochemical secretions known in nature, but despite this complexity, there is a high degree of convergence in toxin structure and targets, making venomous organisms great model systems to investigate areas as diverse as molecular evolution, functional convergence and drug discovery. However, the processes underlying toxin and venom evolution remain poorly understood, particularly in invertebrates. With recent advancements in sequencing and analytical techniques these neglected taxa are being increasingly investigated, revealing a high genetic and functional diversity of venom compounds and challenging traditional views about venom evolution. Still, many phyla such as ribbon worms (Nemertea), active predators that use toxins for defense and predation, remain understudied. This project aims to investigate venom evolution in Nemertea using an integrative evolutionary venomics approach. I propose to use a transcriptomics-proteomics approach referred to as proteogenomics, combining RNA-seq differential gene expression analysis (DGE) and tandem mass spectrometry-based proteomics (MS/MS) to determine venom composition, and integrate these data with expression and functional morphology data derived from spatial omics, both spatial transcriptomics (ST) and spatial proteomics (MALDI-IMS), transmission and scanning electron microscopy (TEM and SEM). This will advance our understanding of ribbon worm venom systems, and shed new light into the true diversity of animal venoms and their evolution. Additionally, this research will likely uncover novel bioactive compounds, with great potential as drug leads and biotechnological tools, making this project’s findings highly relevant to the H2020 focus area Blue Growth objective of developing new bio-based products, including pharmaceuticals.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "FINDING VENOMS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "FINDING VENOMS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

MultiSeaSpace (2019)

Developing a unified spatial modelling strategy that accounts for interactions between species at different marine trophic levels, and different types of survey data.

Read More  

AMPLE (2019)

A Study of the Notion of Ampleness in Model Theory and Tits Buildings

Read More  

Topo-circuit (2019)

Exploring topological phenomenon in RF circuits

Read More