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GOLDEN SIGNED

Gold-Functionalized Devices and Engineered Nanoparticles: Bioorthogonal Tools for Unprecedented Biomedical Applications

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 GOLDEN project word cloud

Explore the words cloud of the GOLDEN project. It provides you a very rough idea of what is the project "GOLDEN" about.

bioactive    dyes    cancer    transformations    inside    systemically    activate    continuous    perform    multidisciplinary    opportunity    chronic    catalysts    demonstrated    nanoparticles    au    treatment    assembling    immobilized    disorders    ways    metabolic    implants    position    starting    catalysis    academics    release    training    anatomical    monolayers    compounds    unprecedented    carry    brain    privileged    abiotic    atomically    independent    vivo    establishing    bypass    nps    innovative    environments    zebrafish    machinery    biocompatible    despite    herein    provides    collaborations    metallic    exact    tissues    artificial    self    catalytically    bioorthogonal    active    biological    excellence    solid    nanomedical    chemistry    manner    cells    reduce    molecules    capacity    recipient    antineoplastic    fellowship    activation    locations    scientific    systemic    researcher    pain    generate    reactivity    administered    heterogeneous    disciplinary    precise    safe    pharma    therapeutics    tools    localized    entities    adverse    functional    myself    confirm    cross    opens    protected    mediated    precursors    neuromodulators    therapy    mediating    deprotection    developer    manufacture   

Project "GOLDEN" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-07   to  2021-10-06

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 212˙933.00

Map

 Project objective

'Despite recent advances in cancer therapy, many challenges remain to reduce the systemic adverse effects of antineoplastic therapeutics. A major goal in the field is to make nanomedical devices that could bypass the metabolic machinery of cells and perform tasks that are not possible with biological entities, such as the manufacture of bioactive molecules at specific locations in a continuous, atomically precise manner. The use of metallic nanoparticles (NPs) as biocompatible catalysts provides the opportunity to carry out abiotic catalysis inside cancer cells or tissues. Such bioorthogonal reactivity opens up new unprecedented ways of mediating artificial transformations in complex biological systems. Solid supported Au-NPs have recently demonstrated a novel, very promising role as heterogeneous catalysts able to generate bioactive compounds in biological environments. Herein I propose an innovative approach to develop catalytically- active Au-NPs immobilized within implants or 'protected' under self-assembling monolayers to enable the activation of systemically-administered bioactive precursors at specific locations via novel Au-mediated deprotection chemistry. To confirm the in vivo functional capabilities of the devices, I will test the capacity of the novel devices to activate dyes and neuromodulators in the brain of zebrafish. This highly innovative multidisciplinary approach could offer a unique and safe method to release bioactive molecules in exact anatomical locations for the treatment of localized disorders including cancer or chronic pain and, in doing so, promote Scientific Excellence in Europe. As the recipient of the advanced training required to perform such a novel programme of research and developer of such tools, at the end of this fellowship I will reach a privileged position for establishing myself as an independent researcher and starting cross-disciplinary collaborations with academics and Pharma across Europe.'

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The information about "GOLDEN" are provided by the European Opendata Portal: CORDIS opendata.

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