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GOLDEN SIGNED

Gold-Functionalized Devices and Engineered Nanoparticles: Bioorthogonal Tools for Unprecedented Biomedical Applications

Total Cost €

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EC-Contrib. €

0

Partnership

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 GOLDEN project word cloud

Explore the words cloud of the GOLDEN project. It provides you a very rough idea of what is the project "GOLDEN" about.

establishing    reduce    cells    artificial    multidisciplinary    chronic    demonstrated    exact    precursors    innovative    heterogeneous    nps    nanoparticles    zebrafish    capacity    therapy    manufacture    compounds    metabolic    biological    manner    provides    fellowship    mediated    tissues    activate    myself    opens    disciplinary    scientific    monolayers    tools    assembling    inside    systemically    molecules    opportunity    academics    release    cross    despite    biocompatible    adverse    precise    bioorthogonal    cancer    catalysis    perform    excellence    herein    protected    metallic    collaborations    immobilized    position    implants    disorders    therapeutics    safe    localized    transformations    administered    solid    chemistry    carry    deprotection    generate    pain    neuromodulators    functional    machinery    anatomical    reactivity    researcher    vivo    starting    mediating    independent    treatment    environments    antineoplastic    unprecedented    training    active    nanomedical    pharma    systemic    entities    developer    brain    bioactive    ways    recipient    dyes    locations    confirm    catalysts    bypass    activation    abiotic    au    atomically    catalytically    privileged    continuous    self   

Project "GOLDEN" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-07   to  2021-10-06

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 212˙933.00

Map

 Project objective

'Despite recent advances in cancer therapy, many challenges remain to reduce the systemic adverse effects of antineoplastic therapeutics. A major goal in the field is to make nanomedical devices that could bypass the metabolic machinery of cells and perform tasks that are not possible with biological entities, such as the manufacture of bioactive molecules at specific locations in a continuous, atomically precise manner. The use of metallic nanoparticles (NPs) as biocompatible catalysts provides the opportunity to carry out abiotic catalysis inside cancer cells or tissues. Such bioorthogonal reactivity opens up new unprecedented ways of mediating artificial transformations in complex biological systems. Solid supported Au-NPs have recently demonstrated a novel, very promising role as heterogeneous catalysts able to generate bioactive compounds in biological environments. Herein I propose an innovative approach to develop catalytically- active Au-NPs immobilized within implants or 'protected' under self-assembling monolayers to enable the activation of systemically-administered bioactive precursors at specific locations via novel Au-mediated deprotection chemistry. To confirm the in vivo functional capabilities of the devices, I will test the capacity of the novel devices to activate dyes and neuromodulators in the brain of zebrafish. This highly innovative multidisciplinary approach could offer a unique and safe method to release bioactive molecules in exact anatomical locations for the treatment of localized disorders including cancer or chronic pain and, in doing so, promote Scientific Excellence in Europe. As the recipient of the advanced training required to perform such a novel programme of research and developer of such tools, at the end of this fellowship I will reach a privileged position for establishing myself as an independent researcher and starting cross-disciplinary collaborations with academics and Pharma across Europe.'

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The information about "GOLDEN" are provided by the European Opendata Portal: CORDIS opendata.

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