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GOLDEN SIGNED

Gold-Functionalized Devices and Engineered Nanoparticles: Bioorthogonal Tools for Unprecedented Biomedical Applications

Total Cost €

0

EC-Contrib. €

0

Partnership

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 GOLDEN project word cloud

Explore the words cloud of the GOLDEN project. It provides you a very rough idea of what is the project "GOLDEN" about.

systemically    perform    assembling    disciplinary    therapeutics    opportunity    zebrafish    bypass    metabolic    implants    metallic    activate    bioactive    adverse    treatment    dyes    capacity    anatomical    catalysis    molecules    environments    administered    activation    herein    academics    artificial    nanoparticles    independent    therapy    pharma    localized    precursors    unprecedented    disorders    mediated    collaborations    machinery    manner    release    manufacture    provides    safe    reduce    mediating    generate    brain    entities    exact    tools    abiotic    fellowship    atomically    functional    carry    compounds    transformations    cross    training    antineoplastic    biocompatible    cells    starting    active    despite    recipient    scientific    excellence    reactivity    nps    pain    locations    ways    solid    au    monolayers    bioorthogonal    multidisciplinary    chemistry    researcher    position    innovative    vivo    systemic    confirm    tissues    privileged    catalysts    myself    neuromodulators    continuous    immobilized    protected    deprotection    inside    heterogeneous    catalytically    nanomedical    demonstrated    biological    opens    chronic    self    developer    establishing    cancer    precise   

Project "GOLDEN" data sheet

The following table provides information about the project.

Coordinator		 THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-07   to  2021-10-06

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 212˙933.00

Map

 Project objective

'Despite recent advances in cancer therapy, many challenges remain to reduce the systemic adverse effects of antineoplastic therapeutics. A major goal in the field is to make nanomedical devices that could bypass the metabolic machinery of cells and perform tasks that are not possible with biological entities, such as the manufacture of bioactive molecules at specific locations in a continuous, atomically precise manner. The use of metallic nanoparticles (NPs) as biocompatible catalysts provides the opportunity to carry out abiotic catalysis inside cancer cells or tissues. Such bioorthogonal reactivity opens up new unprecedented ways of mediating artificial transformations in complex biological systems. Solid supported Au-NPs have recently demonstrated a novel, very promising role as heterogeneous catalysts able to generate bioactive compounds in biological environments. Herein I propose an innovative approach to develop catalytically- active Au-NPs immobilized within implants or 'protected' under self-assembling monolayers to enable the activation of systemically-administered bioactive precursors at specific locations via novel Au-mediated deprotection chemistry. To confirm the in vivo functional capabilities of the devices, I will test the capacity of the novel devices to activate dyes and neuromodulators in the brain of zebrafish. This highly innovative multidisciplinary approach could offer a unique and safe method to release bioactive molecules in exact anatomical locations for the treatment of localized disorders including cancer or chronic pain and, in doing so, promote Scientific Excellence in Europe. As the recipient of the advanced training required to perform such a novel programme of research and developer of such tools, at the end of this fellowship I will reach a privileged position for establishing myself as an independent researcher and starting cross-disciplinary collaborations with academics and Pharma across Europe.'

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The information about "GOLDEN" are provided by the European Opendata Portal: CORDIS opendata.

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