INTERFAT SIGNED
Elucidating the impact of the microbiome on adipose tissue immune cell interactions during obesity
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0INTERFAT project word cloud
Explore the words cloud of the INTERFAT project. It provides you a very rough idea of what is the project "INTERFAT" about.
Project "INTERFAT" data sheet
The following table provides information about the project.
| Coordinator |
WEIZMANN INSTITUTE OF SCIENCE
Organization address contact info |
| Coordinator Country | Israel [IL] |
| Total cost | 173˙464 € |
| EC max contribution | 173˙464 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2018 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2019 |
| Duration (year-month-day) | from 2019-06-01 to 2021-05-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | WEIZMANN INSTITUTE OF SCIENCE | IL (REHOVOT) | coordinator | 173˙464.00 |
Map
Project objective
Obesity affects hundreds of millions of people worldwide and poses a major burden on global health and economy. Immune cells residing in white adipose tissue (WAT) have recently been highlighted as important factors contributing to metabolic dysfunctions during obesity, which is characterized by chronic low-grade inflammation of fat depots. The yet unresolved interplay between adipocytes and immune cells in the WAT niche represents a major challenge to any rational interference into the metabolic derailments. Likewise, the microbiome has been suggested as a critical mediator of obesity, but the regulatory mechanisms remain elusive.
My project aims at a comprehensive assessment of the adipocytes, the adipose tissue immune cells, and their intercellular communication circuits during high-fat diet-induced obesity, as well as the exploration of the impact of the intestinal microbiota on this dynamic process. First, I will characterize adipocytes and immune cells in WAT at the steady state and during obesity of mice by means of single-nuclei RNA-sequencing. Then, I will utilise these transcriptomic profiles for computational modelling to discover disease-specific cell-to-cell interactions, and validate them in signal transduction experiments. This approach together with the analysis of faecal microbiome transplantations into germ-free mice will define the contribution of intestinal microbiota to the WAT remodelling during obesity.
By elucidating the impact of commensal bacteria on adipose tissue cell-to-cell interaction networks, my project aims to take a radically new approach in studying the microbiome-adipose tissue axis and its mechanistic contribution to the aetiology of the obesity pandemic. This systems biology approach may lead to a conceptual leap forward in our understanding of adipocyte biology and WAT immune cell regulation, thereby exploring possibilities for microbiome-based personalized therapies against adipose tissue inflammation during obesity.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "INTERFAT" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "INTERFAT" are provided by the European Opendata Portal: CORDIS opendata.
More projects from the same programme (H2020-EU.1.3.2.)
CREDit (2020)
Chronological REference Datasets and Sites (CREDit) towards improved accuracy and precision in luminescence-based chronologies
Read More