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CompNanozymes SIGNED

Metal-dependent catalysis of nanozymes: First steps towards computational nanoenzymology

Total Cost €

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EC-Contrib. €

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Partnership

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 CompNanozymes project word cloud

Explore the words cloud of the CompNanozymes project. It provides you a very rough idea of what is the project "CompNanozymes" about.

nanochemistry    group    resembles    gap    function    flexible    cleave    nucleic    nanozymes    alternatives    substrates    multiple    functionalization    substrate    mm    mechanism    gold    generate    chemical    catalytic    closely    experiments    nanomaterial    energy    complexes    chemosensing    resembling    complexity    context    coating    acquire    artificial    cells    ambition    protected    found    acid    nanoparticle    metal    self    skill    qm    multifunctional    simulations    nanoparticles    rna    leader    acids    catalysis    compnanozymes    proteins    nanomedicine    shown    monolayer    difficult    sites    zn    completing    bimetallic    expertise    organization    reached    mechanisms    computational    additional    nanotechnology    enzymes    outer    frontier    computation    aided    metalloenzymes    impacting    surface    structure    innovative    free    nature    fellow    dependent    natural    hybrid    cleavage    advancing    fill    coupled    model    made    stable    independent    dynamics    relationships    grow    metallo    nanodesign   

Project "CompNanozymes" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 183˙473 €
 EC max contribution 183˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 183˙473.00

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 Project objective

The functionalization of monolayer-protected gold nanoparticles is at the frontier of nanotechnology, with innovative applications emerging in fields such as nanomedicine, chemosensing, and catalysis. Here, we focus on nanomaterial-based artificial enzymes called nanozymes, which have been shown to be highly stable and low-cost alternatives to natural enzymes in a wide range of applications. For example, the self-organization of Zn complexes on the surface of gold nanozymes has been shown to generate multiple bimetallic catalytic sites capable of promoting the cleavage of an RNA model substrate. This two-metal-aided mechanism found in nanozymes closely resembles that used by many metalloenzymes that process nucleic acids in cells. However, the complex, hybrid, and flexible nature of the outer coating monolayer of nanozymes has so far made it difficult to investigate the structure and dynamics of these multifunctional chemical systems, which have reached a level of complexity resembling that of proteins. Within this context, this project’s ambition is to use classical and hybrid QM/MM simulations coupled to free-energy computation, integrated with experiments, to study the metallo-dependent functionality and mechanisms of nanozymes that cleave nucleic acid model substrates. Through CompNanozymes, the fellow will thus acquire additional expertise in computational simulations, completing his research skill set and allowing him to grow into an independent group leader. Success will also fill the large knowledge gap in our understanding of nanoparticle structure-function relationships in nanozymes, advancing the field of computational nanodesign and directly impacting nanochemistry as a whole.

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The information about "COMPNANOZYMES" are provided by the European Opendata Portal: CORDIS opendata.

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