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FIT-SEP SIGNED

Fully integrated technology for predictive diagnosis of sepsis

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 FIT-SEP project word cloud

Explore the words cloud of the FIT-SEP project. It provides you a very rough idea of what is the project "FIT-SEP" about.

class    community    point    engineering    sequences    diseases    sepsis    progression    tissue    dna    medical    molecules    annually    er    infection    26    home    bacteremia    containing    war    practitioner    syndrome    inexpensive    multidisciplinary    innovation    streptococcus    pyogenes    pcr    shock    rapid    absence    zones    mortality    superantigens    play    combines    diagnosis    mrsa    hospitals    serum    combined    kills    strategy    toxin    effort    exacerbated    sometimes    toxins    microfluidic    biomarkers    nanorod    superantigen    protein    deaths    bacterial    sensitivity    coding    appropriate    spread    chip    toxic    bacteria    implant    countries    devised    hormones    colonise    chemical    eden    pathogenic    plug    skin    office    situation    progress    found    immune    tonsillitis    detector    aureus    individuals    analyte    prototype    saphylococcus    explosives    deep    multiple    care    quantified    infectious    ultrasensitive    detection    array    50    particles    people    pollutants    healthy    nanorods    caused    resistant    expertise    hence    lab    disaster    antibiotic    affordable    predict    income    binding    action    millions    immunodetection    detect    causes   

Project "FIT-SEP" data sheet

The following table provides information about the project.

Coordinator
EDEN MICROFLUIDICS 

Organization address
address: 83 AVENUE PHILIPPE AUGUSTE
city: PARIS
postcode: 75011
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EDEN MICROFLUIDICS FR (PARIS) coordinator 196˙707.00

Map

 Project objective

This proposal features a novel and inexpensive, plug-and-play ultrasensitive immune-PCR fully integrated system (lab-on-chip) that will help with early diagnosis of sepsis or toxic shock syndrome caused by pathogenic bacteria Saphylococcus aureus and Streptococcus pyogenes. Sepsis kills 5.1 millions of people annually; it has up to 26% mortality and rapid progression. S. aureus and S. pyogenes colonise ~50% healthy individuals, and cause common diseases such as tonsillitis, skin and deep tissue or medical implant infection, which sometimes progress to sepsis. Biomarkers that predict of S. aureus and S. pyogenes-caused sepsis are bacterial toxins, superantigens. S. aureus causes most deaths from infectious diseases in high-income countries. This situation is exacerbated by spread of multiple antibiotic resistant S. aureus (MRSA) in the community and hospitals. Superantigens are commonly found in the serum in the absence of bacteremia. It is hence not appropriate to detect them by PCR of the toxin-coding DNA sequences. The key to our innovation is detection of superantigen protein using novel DNA-containing detector nanorods. Binding of the detector particles to the analyte will be quantified via the nanorod DNA. This strategy (immune-PCR) combines immunodetection with sensitivity of PCR to achieve ultrasensitive detection. The system devised in this action will be a prototype for a novel class of devices for ultrasensitive detection of wide array of molecules, including explosives, hormones, or chemical pollutants. The affordable all-in-one plug and play design will allow use in the general practitioner’s office (point of care), at home, or even in the war zones or disaster areas. Development of fully integrated point-of-care lab-on-chip prototype will require multidisciplinary effort where ER’s novel detector nanorods will be combined with the Eden’s expertise in design and engineering of microfluidic systems.

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The information about "FIT-SEP" are provided by the European Opendata Portal: CORDIS opendata.

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