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FIT-SEP SIGNED

Fully integrated technology for predictive diagnosis of sepsis

Total Cost €

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EC-Contrib. €

0

Partnership

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 FIT-SEP project word cloud

Explore the words cloud of the FIT-SEP project. It provides you a very rough idea of what is the project "FIT-SEP" about.

practitioner    strategy    mortality    toxins    infectious    pollutants    plug    coding    healthy    found    chemical    aureus    immune    tonsillitis    antibiotic    progress    exacerbated    toxic    analyte    immunodetection    quantified    pathogenic    individuals    people    multidisciplinary    income    diseases    annually    pcr    spread    causes    saphylococcus    expertise    affordable    combined    detector    tissue    bacteremia    biomarkers    hormones    sensitivity    bacterial    caused    infection    shock    array    home    binding    containing    inexpensive    toxin    countries    eden    hospitals    predict    er    class    millions    zones    play    hence    pyogenes    appropriate    detect    syndrome    deaths    situation    effort    superantigens    mrsa    community    detection    resistant    chip    streptococcus    sequences    kills    microfluidic    skin    absence    rapid    disaster    protein    serum    particles    dna    nanorods    combines    war    medical    point    prototype    office    diagnosis    superantigen    sometimes    nanorod    lab    explosives    deep    bacteria    innovation    colonise    progression    26    care    devised    multiple    action    50    ultrasensitive    engineering    sepsis    molecules    implant   

Project "FIT-SEP" data sheet

The following table provides information about the project.

Coordinator
EDEN MICROFLUIDICS 

Organization address
address: 83 AVENUE PHILIPPE AUGUSTE
city: PARIS
postcode: 75011
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EDEN MICROFLUIDICS FR (PARIS) coordinator 196˙707.00

Map

 Project objective

This proposal features a novel and inexpensive, plug-and-play ultrasensitive immune-PCR fully integrated system (lab-on-chip) that will help with early diagnosis of sepsis or toxic shock syndrome caused by pathogenic bacteria Saphylococcus aureus and Streptococcus pyogenes. Sepsis kills 5.1 millions of people annually; it has up to 26% mortality and rapid progression. S. aureus and S. pyogenes colonise ~50% healthy individuals, and cause common diseases such as tonsillitis, skin and deep tissue or medical implant infection, which sometimes progress to sepsis. Biomarkers that predict of S. aureus and S. pyogenes-caused sepsis are bacterial toxins, superantigens. S. aureus causes most deaths from infectious diseases in high-income countries. This situation is exacerbated by spread of multiple antibiotic resistant S. aureus (MRSA) in the community and hospitals. Superantigens are commonly found in the serum in the absence of bacteremia. It is hence not appropriate to detect them by PCR of the toxin-coding DNA sequences. The key to our innovation is detection of superantigen protein using novel DNA-containing detector nanorods. Binding of the detector particles to the analyte will be quantified via the nanorod DNA. This strategy (immune-PCR) combines immunodetection with sensitivity of PCR to achieve ultrasensitive detection. The system devised in this action will be a prototype for a novel class of devices for ultrasensitive detection of wide array of molecules, including explosives, hormones, or chemical pollutants. The affordable all-in-one plug and play design will allow use in the general practitioner’s office (point of care), at home, or even in the war zones or disaster areas. Development of fully integrated point-of-care lab-on-chip prototype will require multidisciplinary effort where ER’s novel detector nanorods will be combined with the Eden’s expertise in design and engineering of microfluidic systems.

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The information about "FIT-SEP" are provided by the European Opendata Portal: CORDIS opendata.

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