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FIT-SEP SIGNED

Fully integrated technology for predictive diagnosis of sepsis

Total Cost €

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EC-Contrib. €

0

Partnership

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 FIT-SEP project word cloud

Explore the words cloud of the FIT-SEP project. It provides you a very rough idea of what is the project "FIT-SEP" about.

millions    dna    sequences    toxin    innovation    analyte    sensitivity    eden    infection    strategy    spread    expertise    individuals    diseases    50    molecules    prototype    affordable    zones    immunodetection    point    devised    protein    detect    immune    syndrome    lab    plug    disaster    appropriate    pcr    multidisciplinary    practitioner    skin    kills    sepsis    resistant    nanorod    healthy    bacterial    found    coding    rapid    toxic    absence    detection    inexpensive    containing    causes    mrsa    chip    streptococcus    caused    binding    hence    nanorods    particles    multiple    progression    office    infectious    play    countries    ultrasensitive    toxins    antibiotic    pollutants    quantified    pyogenes    progress    combined    shock    superantigens    people    array    annually    sometimes    community    superantigen    deaths    situation    chemical    action    pathogenic    care    implant    combines    er    bacteria    deep    26    effort    home    explosives    bacteremia    hormones    tissue    saphylococcus    engineering    hospitals    predict    war    detector    diagnosis    microfluidic    biomarkers    aureus    colonise    mortality    income    medical    tonsillitis    serum    exacerbated    class   

Project "FIT-SEP" data sheet

The following table provides information about the project.

Coordinator
EDEN MICROFLUIDICS 

Organization address
address: 83 AVENUE PHILIPPE AUGUSTE
city: PARIS
postcode: 75011
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EDEN MICROFLUIDICS FR (PARIS) coordinator 196˙707.00

Map

 Project objective

This proposal features a novel and inexpensive, plug-and-play ultrasensitive immune-PCR fully integrated system (lab-on-chip) that will help with early diagnosis of sepsis or toxic shock syndrome caused by pathogenic bacteria Saphylococcus aureus and Streptococcus pyogenes. Sepsis kills 5.1 millions of people annually; it has up to 26% mortality and rapid progression. S. aureus and S. pyogenes colonise ~50% healthy individuals, and cause common diseases such as tonsillitis, skin and deep tissue or medical implant infection, which sometimes progress to sepsis. Biomarkers that predict of S. aureus and S. pyogenes-caused sepsis are bacterial toxins, superantigens. S. aureus causes most deaths from infectious diseases in high-income countries. This situation is exacerbated by spread of multiple antibiotic resistant S. aureus (MRSA) in the community and hospitals. Superantigens are commonly found in the serum in the absence of bacteremia. It is hence not appropriate to detect them by PCR of the toxin-coding DNA sequences. The key to our innovation is detection of superantigen protein using novel DNA-containing detector nanorods. Binding of the detector particles to the analyte will be quantified via the nanorod DNA. This strategy (immune-PCR) combines immunodetection with sensitivity of PCR to achieve ultrasensitive detection. The system devised in this action will be a prototype for a novel class of devices for ultrasensitive detection of wide array of molecules, including explosives, hormones, or chemical pollutants. The affordable all-in-one plug and play design will allow use in the general practitioner’s office (point of care), at home, or even in the war zones or disaster areas. Development of fully integrated point-of-care lab-on-chip prototype will require multidisciplinary effort where ER’s novel detector nanorods will be combined with the Eden’s expertise in design and engineering of microfluidic systems.

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The information about "FIT-SEP" are provided by the European Opendata Portal: CORDIS opendata.

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