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FIT-SEP SIGNED

Fully integrated technology for predictive diagnosis of sepsis

Total Cost €

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EC-Contrib. €

0

Partnership

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 FIT-SEP project word cloud

Explore the words cloud of the FIT-SEP project. It provides you a very rough idea of what is the project "FIT-SEP" about.

caused    progress    found    spread    situation    containing    income    tissue    progression    nanorod    antibiotic    practitioner    50    colonise    action    syndrome    healthy    serum    detect    strategy    inexpensive    millions    prototype    deaths    community    protein    skin    devised    sepsis    countries    pcr    hormones    eden    saphylococcus    toxin    superantigen    plug    explosives    microfluidic    engineering    appropriate    sequences    particles    bacteria    sometimes    aureus    deep    resistant    war    care    immune    pyogenes    bacterial    toxic    superantigens    detection    people    nanorods    26    hence    chip    diseases    innovation    exacerbated    predict    er    shock    combines    class    analyte    mortality    causes    toxins    individuals    immunodetection    home    expertise    rapid    zones    absence    play    medical    quantified    array    pathogenic    point    combined    diagnosis    bacteremia    dna    pollutants    coding    multiple    sensitivity    effort    detector    kills    tonsillitis    biomarkers    molecules    binding    multidisciplinary    lab    ultrasensitive    annually    mrsa    streptococcus    chemical    disaster    infection    hospitals    office    implant    affordable    infectious   

Project "FIT-SEP" data sheet

The following table provides information about the project.

Coordinator
EDEN MICROFLUIDICS 

Organization address
address: 83 AVENUE PHILIPPE AUGUSTE
city: PARIS
postcode: 75011
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EDEN MICROFLUIDICS FR (PARIS) coordinator 196˙707.00

Map

 Project objective

This proposal features a novel and inexpensive, plug-and-play ultrasensitive immune-PCR fully integrated system (lab-on-chip) that will help with early diagnosis of sepsis or toxic shock syndrome caused by pathogenic bacteria Saphylococcus aureus and Streptococcus pyogenes. Sepsis kills 5.1 millions of people annually; it has up to 26% mortality and rapid progression. S. aureus and S. pyogenes colonise ~50% healthy individuals, and cause common diseases such as tonsillitis, skin and deep tissue or medical implant infection, which sometimes progress to sepsis. Biomarkers that predict of S. aureus and S. pyogenes-caused sepsis are bacterial toxins, superantigens. S. aureus causes most deaths from infectious diseases in high-income countries. This situation is exacerbated by spread of multiple antibiotic resistant S. aureus (MRSA) in the community and hospitals. Superantigens are commonly found in the serum in the absence of bacteremia. It is hence not appropriate to detect them by PCR of the toxin-coding DNA sequences. The key to our innovation is detection of superantigen protein using novel DNA-containing detector nanorods. Binding of the detector particles to the analyte will be quantified via the nanorod DNA. This strategy (immune-PCR) combines immunodetection with sensitivity of PCR to achieve ultrasensitive detection. The system devised in this action will be a prototype for a novel class of devices for ultrasensitive detection of wide array of molecules, including explosives, hormones, or chemical pollutants. The affordable all-in-one plug and play design will allow use in the general practitioner’s office (point of care), at home, or even in the war zones or disaster areas. Development of fully integrated point-of-care lab-on-chip prototype will require multidisciplinary effort where ER’s novel detector nanorods will be combined with the Eden’s expertise in design and engineering of microfluidic systems.

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The information about "FIT-SEP" are provided by the European Opendata Portal: CORDIS opendata.

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