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FIT-SEP SIGNED

Fully integrated technology for predictive diagnosis of sepsis

Total Cost €

0

EC-Contrib. €

0

Partnership

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 FIT-SEP project word cloud

Explore the words cloud of the FIT-SEP project. It provides you a very rough idea of what is the project "FIT-SEP" about.

lab    innovation    syndrome    inexpensive    progress    healthy    containing    situation    war    found    quantified    superantigen    pollutants    detector    multiple    expertise    molecules    plug    er    streptococcus    detect    50    disaster    toxin    chemical    annually    explosives    medical    sensitivity    diagnosis    combined    care    shock    pyogenes    antibiotic    appropriate    spread    hormones    bacterial    practitioner    predict    implant    combines    pathogenic    progression    bacteremia    class    causes    income    rapid    prototype    mrsa    absence    infection    immune    point    exacerbated    nanorod    coding    multidisciplinary    particles    people    toxic    community    bacteria    aureus    kills    pcr    dna    ultrasensitive    toxins    chip    action    millions    engineering    sometimes    tissue    diseases    deep    infectious    skin    26    sepsis    protein    countries    eden    tonsillitis    biomarkers    individuals    strategy    resistant    home    array    mortality    colonise    serum    binding    sequences    detection    analyte    microfluidic    caused    superantigens    affordable    zones    saphylococcus    nanorods    effort    immunodetection    hospitals    play    deaths    office    devised    hence   

Project "FIT-SEP" data sheet

The following table provides information about the project.

Coordinator
EDEN MICROFLUIDICS 

Organization address
address: 83 AVENUE PHILIPPE AUGUSTE
city: PARIS
postcode: 75011
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EDEN MICROFLUIDICS FR (PARIS) coordinator 196˙707.00

Map

 Project objective

This proposal features a novel and inexpensive, plug-and-play ultrasensitive immune-PCR fully integrated system (lab-on-chip) that will help with early diagnosis of sepsis or toxic shock syndrome caused by pathogenic bacteria Saphylococcus aureus and Streptococcus pyogenes. Sepsis kills 5.1 millions of people annually; it has up to 26% mortality and rapid progression. S. aureus and S. pyogenes colonise ~50% healthy individuals, and cause common diseases such as tonsillitis, skin and deep tissue or medical implant infection, which sometimes progress to sepsis. Biomarkers that predict of S. aureus and S. pyogenes-caused sepsis are bacterial toxins, superantigens. S. aureus causes most deaths from infectious diseases in high-income countries. This situation is exacerbated by spread of multiple antibiotic resistant S. aureus (MRSA) in the community and hospitals. Superantigens are commonly found in the serum in the absence of bacteremia. It is hence not appropriate to detect them by PCR of the toxin-coding DNA sequences. The key to our innovation is detection of superantigen protein using novel DNA-containing detector nanorods. Binding of the detector particles to the analyte will be quantified via the nanorod DNA. This strategy (immune-PCR) combines immunodetection with sensitivity of PCR to achieve ultrasensitive detection. The system devised in this action will be a prototype for a novel class of devices for ultrasensitive detection of wide array of molecules, including explosives, hormones, or chemical pollutants. The affordable all-in-one plug and play design will allow use in the general practitioner’s office (point of care), at home, or even in the war zones or disaster areas. Development of fully integrated point-of-care lab-on-chip prototype will require multidisciplinary effort where ER’s novel detector nanorods will be combined with the Eden’s expertise in design and engineering of microfluidic systems.

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The information about "FIT-SEP" are provided by the European Opendata Portal: CORDIS opendata.

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