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VEGFDANI

Novel enhancers of functional recovery after stroke

Total Cost €

0

EC-Contrib. €

0

Partnership

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 VEGFDANI project word cloud

Explore the words cloud of the VEGFDANI project. It provides you a very rough idea of what is the project "VEGFDANI" about.

vpm    discovery    activators    transient    recovery    erc    forms    companies    nuclear    starting    led    platform    biologically    mimicking    neuroadaptation    collaborative    transfer    add    cognition    function    innovative    strategy    experts    poc    ip    clear    company    partnership    negotiate    originating    signaling    manipulating    budget    anti    several    neurological    period    network    prevents    genes    plan    neuronal    showed    lack    risks    mimetic    active    senior    first    spray    model    underlie    validate    disorders    gene    expression    screening    vegfd    strategies    concentration    conceptually    peptide    dependent    nasal    dendritic    partnering    advised    therapy    calcium    stroke    industry    modulation    inhibitors    mass    fund    therapeutic    ncsa    meet    regulates    morphology    prior    drug    close    area    commercialization    protective    complete    demonstrated    promotes    233024    assays    brain    expand    validation    regulator    helped    alterations    minimizing    professionals    mouse    commercial    business    direct   

Project "VEGFDANI" data sheet

The following table provides information about the project.

Coordinator
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG 

Organization address
address: SEMINARSTRASSE 2
city: HEIDELBERG
postcode: 69117
website: www.uni-heidelberg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 147˙968 €
 EC max contribution 147˙968 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-03-01   to  2016-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG DE (HEIDELBERG) coordinator 147˙968.00

Map

 Project objective

Several forms of neuroadaptation are controlled by transient increases in the nuclear calcium concentration. Nuclear calcium regulates expression of crucial genes and alterations of this signaling network likely underlie many neurological disorders. Our work led us to design two innovative strategies exploiting the therapeutic potential of nuclear calcium signaling: 1-developing direct nuclear calcium signaling activators/inhibitors (NCSA/I) and 2-manipulating expression and/or function of nuclear calcium targets. The proposed activities and budget - taking the ERC-PoC stroke study as the model project – will be used to meet the essential pre-commercial requirements prior starting up a company focusing on early drug discovery in the area of targeted nuclear calcium signaling modulation:

R&D objectives: 1-PoC to validate our lead mimicking a stroke-protective regulator: VEGFD; 2-Add novel drug targets & assays and transfer to screening partner; 3-Mass screening and lead validation to expand IP; Business objectives: 1-Manage emerging IP platform; 2-Complete fund raising during ERC funding period; 3-Close early drug discovery partnership.

As part of the ERC project 233024, we identified a nuclear-calcium dependent gene, VEGFD, as a new anti-stroke drug target. We showed that VEGFD regulates neuronal morphology and cognition and demonstrated that VEGFD delivery in the mouse brain prevents stroke-induced dendritic loss and promotes long-term recovery. We selected a highly biologically active VEGFD peptide mimetic (VPM) as our first lead for a conceptually novel nasal spray stroke therapy.

Senior business experts advised and helped us to establish a business plan and to pre-negotiate collaborative partnerships with companies and institutions required to deliver on our objectives. Thus, by partnering with industry professionals we were able to define a clear go-to-commercialization strategy while minimizing risks originating from possible lack of business experience.

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The information about "VEGFDANI" are provided by the European Opendata Portal: CORDIS opendata.

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