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VEGFDANI

Novel enhancers of functional recovery after stroke

Total Cost €

0

EC-Contrib. €

0

Partnership

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 VEGFDANI project word cloud

Explore the words cloud of the VEGFDANI project. It provides you a very rough idea of what is the project "VEGFDANI" about.

first    negotiate    several    meet    active    disorders    transfer    ip    alterations    inhibitors    dependent    commercialization    modulation    direct    nuclear    partnering    manipulating    budget    mouse    therapy    strategy    platform    starting    drug    company    erc    therapeutic    neuronal    lack    minimizing    innovative    period    partnership    conceptually    activators    signaling    industry    transient    mimicking    helped    regulates    stroke    experts    validation    complete    commercial    promotes    discovery    underlie    calcium    prevents    vegfd    ncsa    screening    recovery    cognition    mass    prior    brain    professionals    fund    peptide    expand    forms    companies    close    anti    gene    showed    mimetic    dendritic    senior    233024    morphology    advised    biologically    business    protective    strategies    validate    poc    originating    neurological    nasal    function    regulator    spray    network    demonstrated    vpm    risks    collaborative    expression    concentration    led    add    clear    genes    area    plan    neuroadaptation    model    assays   

Project "VEGFDANI" data sheet

The following table provides information about the project.

Coordinator
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG 

Organization address
address: SEMINARSTRASSE 2
city: HEIDELBERG
postcode: 69117
website: www.uni-heidelberg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 147˙968 €
 EC max contribution 147˙968 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-03-01   to  2016-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG DE (HEIDELBERG) coordinator 147˙968.00

Map

 Project objective

Several forms of neuroadaptation are controlled by transient increases in the nuclear calcium concentration. Nuclear calcium regulates expression of crucial genes and alterations of this signaling network likely underlie many neurological disorders. Our work led us to design two innovative strategies exploiting the therapeutic potential of nuclear calcium signaling: 1-developing direct nuclear calcium signaling activators/inhibitors (NCSA/I) and 2-manipulating expression and/or function of nuclear calcium targets. The proposed activities and budget - taking the ERC-PoC stroke study as the model project – will be used to meet the essential pre-commercial requirements prior starting up a company focusing on early drug discovery in the area of targeted nuclear calcium signaling modulation:

R&D objectives: 1-PoC to validate our lead mimicking a stroke-protective regulator: VEGFD; 2-Add novel drug targets & assays and transfer to screening partner; 3-Mass screening and lead validation to expand IP; Business objectives: 1-Manage emerging IP platform; 2-Complete fund raising during ERC funding period; 3-Close early drug discovery partnership.

As part of the ERC project 233024, we identified a nuclear-calcium dependent gene, VEGFD, as a new anti-stroke drug target. We showed that VEGFD regulates neuronal morphology and cognition and demonstrated that VEGFD delivery in the mouse brain prevents stroke-induced dendritic loss and promotes long-term recovery. We selected a highly biologically active VEGFD peptide mimetic (VPM) as our first lead for a conceptually novel nasal spray stroke therapy.

Senior business experts advised and helped us to establish a business plan and to pre-negotiate collaborative partnerships with companies and institutions required to deliver on our objectives. Thus, by partnering with industry professionals we were able to define a clear go-to-commercialization strategy while minimizing risks originating from possible lack of business experience.

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The information about "VEGFDANI" are provided by the European Opendata Portal: CORDIS opendata.

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