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VEGFDANI

Novel enhancers of functional recovery after stroke

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 VEGFDANI project word cloud

Explore the words cloud of the VEGFDANI project. It provides you a very rough idea of what is the project "VEGFDANI" about.

regulator    promotes    originating    commercial    activators    ncsa    starting    transfer    mimetic    partnership    close    morphology    brain    nasal    manipulating    company    anti    industry    active    erc    dependent    innovative    protective    biologically    professionals    strategies    signaling    validation    233024    conceptually    risks    neurological    neuroadaptation    lack    calcium    prior    period    poc    underlie    helped    area    spray    cognition    transient    expand    strategy    commercialization    drug    complete    regulates    vegfd    model    disorders    gene    minimizing    genes    vpm    budget    several    expression    companies    fund    function    plan    screening    prevents    add    showed    stroke    platform    recovery    mimicking    meet    concentration    therapy    partnering    modulation    neuronal    ip    direct    network    nuclear    first    peptide    inhibitors    senior    led    alterations    forms    validate    clear    therapeutic    dendritic    experts    collaborative    discovery    advised    business    negotiate    assays    mass    demonstrated    mouse   

Project "VEGFDANI" data sheet

The following table provides information about the project.

Coordinator
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG 

Organization address
address: SEMINARSTRASSE 2
city: HEIDELBERG
postcode: 69117
website: www.uni-heidelberg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 147˙968 €
 EC max contribution 147˙968 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-03-01   to  2016-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG DE (HEIDELBERG) coordinator 147˙968.00

Map

 Project objective

Several forms of neuroadaptation are controlled by transient increases in the nuclear calcium concentration. Nuclear calcium regulates expression of crucial genes and alterations of this signaling network likely underlie many neurological disorders. Our work led us to design two innovative strategies exploiting the therapeutic potential of nuclear calcium signaling: 1-developing direct nuclear calcium signaling activators/inhibitors (NCSA/I) and 2-manipulating expression and/or function of nuclear calcium targets. The proposed activities and budget - taking the ERC-PoC stroke study as the model project – will be used to meet the essential pre-commercial requirements prior starting up a company focusing on early drug discovery in the area of targeted nuclear calcium signaling modulation:

R&D objectives: 1-PoC to validate our lead mimicking a stroke-protective regulator: VEGFD; 2-Add novel drug targets & assays and transfer to screening partner; 3-Mass screening and lead validation to expand IP; Business objectives: 1-Manage emerging IP platform; 2-Complete fund raising during ERC funding period; 3-Close early drug discovery partnership.

As part of the ERC project 233024, we identified a nuclear-calcium dependent gene, VEGFD, as a new anti-stroke drug target. We showed that VEGFD regulates neuronal morphology and cognition and demonstrated that VEGFD delivery in the mouse brain prevents stroke-induced dendritic loss and promotes long-term recovery. We selected a highly biologically active VEGFD peptide mimetic (VPM) as our first lead for a conceptually novel nasal spray stroke therapy.

Senior business experts advised and helped us to establish a business plan and to pre-negotiate collaborative partnerships with companies and institutions required to deliver on our objectives. Thus, by partnering with industry professionals we were able to define a clear go-to-commercialization strategy while minimizing risks originating from possible lack of business experience.

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The information about "VEGFDANI" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-12-08 6:25:20) correctly updated