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VEGFDANI

Novel enhancers of functional recovery after stroke

Total Cost €

0

EC-Contrib. €

0

Partnership

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 VEGFDANI project word cloud

Explore the words cloud of the VEGFDANI project. It provides you a very rough idea of what is the project "VEGFDANI" about.

commercialization    prevents    ncsa    cognition    partnership    plan    meet    discovery    first    platform    stroke    underlie    originating    alterations    peptide    genes    collaborative    biologically    fund    transient    negotiate    forms    manipulating    drug    demonstrated    advised    morphology    period    recovery    area    233024    starting    commercial    dependent    minimizing    calcium    ip    brain    gene    add    expression    regulator    clear    innovative    complete    conceptually    anti    close    concentration    showed    assays    validate    network    industry    vegfd    signaling    activators    budget    mimicking    neurological    poc    partnering    strategies    vpm    companies    mouse    spray    nuclear    active    modulation    therapy    nasal    prior    erc    strategy    lack    neuroadaptation    screening    expand    helped    regulates    dendritic    mass    experts    promotes    function    therapeutic    protective    led    direct    model    mimetic    transfer    professionals    neuronal    business    disorders    validation    company    risks    inhibitors    senior    several   

Project "VEGFDANI" data sheet

The following table provides information about the project.

Coordinator
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG 

Organization address
address: SEMINARSTRASSE 2
city: HEIDELBERG
postcode: 69117
website: www.uni-heidelberg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 147˙968 €
 EC max contribution 147˙968 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-03-01   to  2016-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG DE (HEIDELBERG) coordinator 147˙968.00

Map

 Project objective

Several forms of neuroadaptation are controlled by transient increases in the nuclear calcium concentration. Nuclear calcium regulates expression of crucial genes and alterations of this signaling network likely underlie many neurological disorders. Our work led us to design two innovative strategies exploiting the therapeutic potential of nuclear calcium signaling: 1-developing direct nuclear calcium signaling activators/inhibitors (NCSA/I) and 2-manipulating expression and/or function of nuclear calcium targets. The proposed activities and budget - taking the ERC-PoC stroke study as the model project – will be used to meet the essential pre-commercial requirements prior starting up a company focusing on early drug discovery in the area of targeted nuclear calcium signaling modulation:

R&D objectives: 1-PoC to validate our lead mimicking a stroke-protective regulator: VEGFD; 2-Add novel drug targets & assays and transfer to screening partner; 3-Mass screening and lead validation to expand IP; Business objectives: 1-Manage emerging IP platform; 2-Complete fund raising during ERC funding period; 3-Close early drug discovery partnership.

As part of the ERC project 233024, we identified a nuclear-calcium dependent gene, VEGFD, as a new anti-stroke drug target. We showed that VEGFD regulates neuronal morphology and cognition and demonstrated that VEGFD delivery in the mouse brain prevents stroke-induced dendritic loss and promotes long-term recovery. We selected a highly biologically active VEGFD peptide mimetic (VPM) as our first lead for a conceptually novel nasal spray stroke therapy.

Senior business experts advised and helped us to establish a business plan and to pre-negotiate collaborative partnerships with companies and institutions required to deliver on our objectives. Thus, by partnering with industry professionals we were able to define a clear go-to-commercialization strategy while minimizing risks originating from possible lack of business experience.

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The information about "VEGFDANI" are provided by the European Opendata Portal: CORDIS opendata.

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