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GUTPOLAR SIGNED

Membrane trafficking as a link between cell polarity and intestinal absorptive function: from C. elegans to mammalian miniguts

Total Cost €

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EC-Contrib. €

0

Partnership

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 GUTPOLAR project word cloud

Explore the words cloud of the GUTPOLAR project. It provides you a very rough idea of what is the project "GUTPOLAR" about.

diseases    cells    reintegrating    routes    caused    frankfurt    coding    model    rare    vivo    controls    phenotypes    depletion    genetics    gutpolar    apical    traffic    mammalian    medical    mammals    recapitulates    therapeutic    community    absorption    imaging    epithelial    acquire    mutations    skills    evolutionary    thanks    researcher    despite    array    structural    molecular    microvilli    sustainably    mispolarized    mechanisms    super    conservation    function    border    relies    mechanism    disease    maintenance    organelle    intestinal    elegans    interactions    conserved    functional    bb    er    malabsorption    components    mouse    he    atpase    candidate    polarity    genes    v0    organoids    first    myo5b    par    intestine    action    describe    luminal    interestingly    uncovered    brush    disorders    genetic    lab    microvillus    modules    food    farin    reinforce    link    little    trafficking    physical    pole    mvid    secondment    acidification    cellular    patients    proteins    germany    forming    resolution    inclusion    membrane   

Project "GUTPOLAR" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-05-06   to  2021-05-05

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 196˙707.00

Map

 Project objective

The GUTPOLAR project aims at sustainably reintegrating an Experience Researcher (ER) who will acquire the necessary knowledge and skills to reinforce European research on rare malabsorption diseases. Food absorption relies on the strong polarity of intestinal epithelial cells and the array of microvilli forming a brush border (BB) at their luminal (apical) pole. Some rare genetic malabsorption disorders, characterized by mispolarized PAR polarity modules and BB structural proteins, are caused by mutations in genes coding for membrane traffic factors (i.e. Myo5B in microvillus inclusion disease/MVID). Despite this functional link, little is known about the genetic, physical and functional interactions between membrane traffic, polarity and BB components in vivo and how they control intestinal absorption. The ER uncovered a new role of the V0 sector of the V-ATPase, a complex that controls membrane traffic through organelle acidification, in both polarity and BB components apical polarity maintenance in C. elegans intestine. Most interestingly, V0-ATPase depletion in C. elegans recapitulates the cellular phenotypes observed in patients with MVID, making this complex a very exciting candidate which mechanism, genetic partners and mammalian function need to be characterized. To this end, the ER will first use genetics and super-resolution imaging to study the trafficking routes and the molecular mechanisms controlled by the V0-ATPase in vivo in C. elegans intestine. Then, he will implement mouse intestinal organoids (thanks to a secondment in H. Farin’s lab, Frankfurt, Germany) and use this model to study the conservation of these mechanisms in mammals. Overall, the GUTPOLAR action will allow to describe evolutionary conserved pathways of polarity maintenance and identify some of the mechanisms leading to absorption disorders that may provide the medical community with new therapeutic targets.

 Publications

year authors and title journal last update
List of publications.
2019 Aurélien Bidaud-Meynard, Ophélie Nicolle, Markus Heck, Yann Le Cunff, Grégoire Michaux
A V0-ATPase-dependent apical trafficking pathway maintains the polarity of the intestinal absorptive membrane
published pages: dev174508, ISSN: 0950-1991, DOI: 10.1242/dev.174508
Development 146/11 2019-07-22

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