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GUTPOLAR SIGNED

Membrane trafficking as a link between cell polarity and intestinal absorptive function: from C. elegans to mammalian miniguts

Total Cost €

0

EC-Contrib. €

0

Partnership

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 GUTPOLAR project word cloud

Explore the words cloud of the GUTPOLAR project. It provides you a very rough idea of what is the project "GUTPOLAR" about.

structural    therapeutic    frankfurt    germany    despite    disease    maintenance    he    molecular    luminal    mouse    imaging    diseases    microvilli    patients    describe    inclusion    acquire    array    mammals    absorption    uncovered    gutpolar    mutations    myo5b    intestinal    organelle    function    cellular    interestingly    vivo    proteins    organoids    intestine    elegans    mammalian    reintegrating    border    er    recapitulates    super    candidate    link    functional    atpase    coding    epithelial    sustainably    modules    forming    microvillus    apical    depletion    little    reinforce    genes    food    skills    thanks    polarity    v0    rare    conserved    interactions    mvid    genetic    controls    phenotypes    farin    secondment    mechanism    mechanisms    model    researcher    acidification    routes    mispolarized    brush    disorders    traffic    first    resolution    components    membrane    conservation    trafficking    physical    pole    par    cells    bb    evolutionary    malabsorption    community    caused    relies    medical    lab    genetics    action   

Project "GUTPOLAR" data sheet

The following table provides information about the project.

Coordinator		 CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-05-06   to  2021-05-05

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 196˙707.00

Map

 Project objective

The GUTPOLAR project aims at sustainably reintegrating an Experience Researcher (ER) who will acquire the necessary knowledge and skills to reinforce European research on rare malabsorption diseases. Food absorption relies on the strong polarity of intestinal epithelial cells and the array of microvilli forming a brush border (BB) at their luminal (apical) pole. Some rare genetic malabsorption disorders, characterized by mispolarized PAR polarity modules and BB structural proteins, are caused by mutations in genes coding for membrane traffic factors (i.e. Myo5B in microvillus inclusion disease/MVID). Despite this functional link, little is known about the genetic, physical and functional interactions between membrane traffic, polarity and BB components in vivo and how they control intestinal absorption. The ER uncovered a new role of the V0 sector of the V-ATPase, a complex that controls membrane traffic through organelle acidification, in both polarity and BB components apical polarity maintenance in C. elegans intestine. Most interestingly, V0-ATPase depletion in C. elegans recapitulates the cellular phenotypes observed in patients with MVID, making this complex a very exciting candidate which mechanism, genetic partners and mammalian function need to be characterized. To this end, the ER will first use genetics and super-resolution imaging to study the trafficking routes and the molecular mechanisms controlled by the V0-ATPase in vivo in C. elegans intestine. Then, he will implement mouse intestinal organoids (thanks to a secondment in H. Farin’s lab, Frankfurt, Germany) and use this model to study the conservation of these mechanisms in mammals. Overall, the GUTPOLAR action will allow to describe evolutionary conserved pathways of polarity maintenance and identify some of the mechanisms leading to absorption disorders that may provide the medical community with new therapeutic targets.

 Publications

year authors and title journal last update
List of publications.
2019 Aurélien Bidaud-Meynard, Ophélie Nicolle, Markus Heck, Yann Le Cunff, Grégoire Michaux
A V0-ATPase-dependent apical trafficking pathway maintains the polarity of the intestinal absorptive membrane
published pages: dev174508, ISSN: 0950-1991, DOI: 10.1242/dev.174508 		Development 146/11 2019-07-22

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