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GUTPOLAR SIGNED

Membrane trafficking as a link between cell polarity and intestinal absorptive function: from C. elegans to mammalian miniguts

Total Cost €

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EC-Contrib. €

0

Partnership

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 GUTPOLAR project word cloud

Explore the words cloud of the GUTPOLAR project. It provides you a very rough idea of what is the project "GUTPOLAR" about.

patients    par    reinforce    little    reintegrating    polarity    structural    recapitulates    medical    cellular    therapeutic    evolutionary    first    mechanism    maintenance    phenotypes    vivo    secondment    mutations    uncovered    pole    functional    genetics    mammals    mvid    modules    luminal    cells    farin    epithelial    inclusion    thanks    physical    relies    link    acquire    caused    despite    depletion    intestine    components    malabsorption    germany    researcher    border    action    forming    proteins    diseases    controls    gutpolar    membrane    disorders    microvillus    interactions    food    he    mammalian    genetic    acidification    organoids    model    v0    interestingly    bb    conserved    candidate    molecular    apical    sustainably    lab    organelle    intestinal    disease    rare    atpase    traffic    myo5b    brush    er    super    array    community    mispolarized    genes    frankfurt    mouse    function    elegans    mechanisms    absorption    skills    microvilli    routes    imaging    conservation    resolution    trafficking    describe    coding   

Project "GUTPOLAR" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-05-06   to  2021-05-05

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 196˙707.00

Map

 Project objective

The GUTPOLAR project aims at sustainably reintegrating an Experience Researcher (ER) who will acquire the necessary knowledge and skills to reinforce European research on rare malabsorption diseases. Food absorption relies on the strong polarity of intestinal epithelial cells and the array of microvilli forming a brush border (BB) at their luminal (apical) pole. Some rare genetic malabsorption disorders, characterized by mispolarized PAR polarity modules and BB structural proteins, are caused by mutations in genes coding for membrane traffic factors (i.e. Myo5B in microvillus inclusion disease/MVID). Despite this functional link, little is known about the genetic, physical and functional interactions between membrane traffic, polarity and BB components in vivo and how they control intestinal absorption. The ER uncovered a new role of the V0 sector of the V-ATPase, a complex that controls membrane traffic through organelle acidification, in both polarity and BB components apical polarity maintenance in C. elegans intestine. Most interestingly, V0-ATPase depletion in C. elegans recapitulates the cellular phenotypes observed in patients with MVID, making this complex a very exciting candidate which mechanism, genetic partners and mammalian function need to be characterized. To this end, the ER will first use genetics and super-resolution imaging to study the trafficking routes and the molecular mechanisms controlled by the V0-ATPase in vivo in C. elegans intestine. Then, he will implement mouse intestinal organoids (thanks to a secondment in H. Farin’s lab, Frankfurt, Germany) and use this model to study the conservation of these mechanisms in mammals. Overall, the GUTPOLAR action will allow to describe evolutionary conserved pathways of polarity maintenance and identify some of the mechanisms leading to absorption disorders that may provide the medical community with new therapeutic targets.

 Publications

year authors and title journal last update
List of publications.
2019 Aurélien Bidaud-Meynard, Ophélie Nicolle, Markus Heck, Yann Le Cunff, Grégoire Michaux
A V0-ATPase-dependent apical trafficking pathway maintains the polarity of the intestinal absorptive membrane
published pages: dev174508, ISSN: 0950-1991, DOI: 10.1242/dev.174508
Development 146/11 2019-07-22

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