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AutoCRAT SIGNED

Automated Cellular Robot-Assisted Technologies for translation of discovery-led research in Osteoarthritis

Total Cost €

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EC-Contrib. €

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Partnership

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Project "AutoCRAT" data sheet

The following table provides information about the project.

Coordinator
NATIONAL UNIVERSITY OF IRELAND GALWAY 

Organization address
address: UNIVERSITY ROAD
city: Galway
postcode: H91
website: www.nuigalway.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 7˙452˙770 €
 EC max contribution 7˙452˙770 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2019-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 1˙406˙250.00
2    FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. DE (MUNCHEN) participant 1˙683˙046.00
3    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 1˙006˙181.00
4    UNIVERSITAETSKLINIKUM ESSEN DE (ESSEN) participant 760˙625.00
5    GOETEBORGS UNIVERSITET SE (GOETEBORG) participant 751˙048.00
6    UNIVERSITA DEGLI STUDI DI GENOVA IT (GENOVA) participant 750˙000.00
7    VALITACELL LTD IE (DUBLIN 2) participant 750˙000.00
8    PINTAIL LTD IE (Blackrock) participant 199˙993.00
9    PANAXEA BV NL (AMSTERDAM) participant 145˙625.00

Map

 Project objective

AutoCRAT will develop novel sustainable cell and cell-derived therapies for osteoarthritis (OA). Osteoarthritis, a major disease, results in degradation of cartilage. It is the most common chronic joint condition, currently affecting >40 million Europeans. As no effective treatments for OA are available, it imposes a huge burden on the individual patient and European health care systems. Adult mesenchymal stem/stromal cells (MSCs) show early, promising clinical treatment efficacy in OA. However, costs of MSC production prevents widespread use for patients. Using human induced pluripotent stem cells (hiPSC), AutoCRAT will generate articular chondrocytes (hiCHOs) for cartilage repair to prevent development of OA and hiMSCs to treat established disease as sustainable therapeutic cell sources for therapies. Discovery of the osteoarthritis-specific hiMSC secretome will enable further refinement of these next-generation therapies; this will be achieved by molecular analysis of: 1) hiMSCs treated with synovial fluid from OA patients 2) EVs derived from these therapeutically-activated cells to develop the therapeutic osteoarthritis secretome. To ensure sustainable supply of high quality, affordable products, AutoCRAT will also develop a manufacturing pipeline composed of automated, regulatory-compliant robotic systems for production of the developed hiCHOs and hiMSCs and cell-secreted extracellular vesicle (EVs). The manufacturing pipeline can be extended to many other major diseases. The AutoCRAT consortium is composed of leading European scientific teams in stem cell biology, OA, preclinical efficacy and safety demonstration, GMP- and GAMP-compliant manufacturing of MSCs, regulatory affairs and health economics analysis. All aspects of AutoCRAT discovery and translation innovations will be guided by the imperative to deliver economically viable and regulatory-compliant therapies to OA-patients, the European health care system at large, and benefits to the European economy.

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The information about "AUTOCRAT" are provided by the European Opendata Portal: CORDIS opendata.

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