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Modulating skin innervation to treat cutaneous inflammation

Total Cost €


EC-Contrib. €






 NEUROSKIN project word cloud

Explore the words cloud of the NEUROSKIN project. It provides you a very rough idea of what is the project "NEUROSKIN" about.

contained    damage    repurpose    cutaneous    exploited    local    etiology    toolbox    extend    neuroskin    electrical    plaques    gut    involvement    skin    psoriasis    healing    innervating    worldwide    receive    introduce    individuals    global    community    characterization    profound    interaction    therapeutic    magnetic    erc    light    additional    external    relatively    interface    sensory    simulation    neurons    continues    densely    disease    stages    inflammation    model    little    subpopulations    technologies    fibers    burden    phases    class    inflammatory    tools    understand    nevertheless    unclear    transgenic    time    autonomic    human    neuronal    entire    peripheral    of    stg    interventions    drugs    innervations    illnesses    despite    pathologies    optogenetic    innervated    manipulations    approximately    mice    disorders    utilize    representing    18th    neuromodulators    mediated    treatment    health    psoriatic    mouse    treat    nerve    world    innervation    forums    tool    map    neurological    functions   

Project "NEUROSKIN" data sheet

The following table provides information about the project.


Organization address
city: HAIFA
postcode: 32000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2020-10-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Skin disease is one of the most common human illnesses. At any given time, approximately one out of three individuals is affected by skin disease and it is the 18th leading cause of health burden worldwide. Despite this profound impact, skin disease continues to receive relatively little attention in global health forums, and the etiology of most of these conditions is unclear. The skin is our major interface with the external world, densely innervated with sensory and autonomic nerve fibers. Thus, neuromodulators are involved during all phases of skin damage and healing. Nevertheless, we do not fully understand the interaction between skin innervation and skin pathologies. More importantly, the therapeutic potential contained in cutaneous innervation has not been exploited. NEUROSKIN will determine how different skin innervations affect psoriasis, a major skin disease, representing the largest class of skin conditions, those that are mediated by inflammation. We will utilize a transgenic mouse model that enables optogenetic control of local peripheral innervations using light. This model was developed as part of our ERC STG to characterize the involvement of peripheral innervation on gut inflammation. In NEUROSKIN, we will extend this tool to develop additional transgenic mice relevant to cutaneous neuronal subpopulations. In these mice, we will control the activity of neurons innervating the psoriatic plaques at different stages of the disease. This will allow us to map potential of targeted neuronal interventions to treat inflammatory skin conditions. Such characterization is expected to introduce an entire set of therapeutic tools based on neurological manipulations, and allow us to repurpose drugs and other technologies (e.g electrical and magnetic simulation) for the potential treatment of skin disorders. Moreover, NEUROSKIN will introduce a new toolbox that will enable the entire community to study the involvement of skin innervation in skin functions.

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The information about "NEUROSKIN" are provided by the European Opendata Portal: CORDIS opendata.

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