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Modulating skin innervation to treat cutaneous inflammation

Total Cost €


EC-Contrib. €






 NEUROSKIN project word cloud

Explore the words cloud of the NEUROSKIN project. It provides you a very rough idea of what is the project "NEUROSKIN" about.

relatively    peripheral    interface    disease    nevertheless    neuroskin    mediated    sensory    light    densely    profound    utilize    entire    little    stg    forums    unclear    toolbox    neurological    community    healing    technologies    innervations    manipulations    individuals    characterization    map    therapeutic    world    treatment    damage    health    innervating    psoriatic    human    treat    subpopulations    mouse    neuronal    global    worldwide    receive    contained    electrical    innervation    extend    neuromodulators    additional    pathologies    mice    interventions    magnetic    phases    fibers    skin    illnesses    involvement    local    continues    transgenic    external    cutaneous    disorders    plaques    approximately    despite    stages    neurons    tools    model    etiology    erc    drugs    psoriasis    simulation    18th    inflammatory    nerve    autonomic    burden    introduce    representing    understand    of    functions    inflammation    time    repurpose    gut    exploited    interaction    tool    optogenetic    innervated    class   

Project "NEUROSKIN" data sheet

The following table provides information about the project.


Organization address
city: HAIFA
postcode: 32000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2020-10-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Skin disease is one of the most common human illnesses. At any given time, approximately one out of three individuals is affected by skin disease and it is the 18th leading cause of health burden worldwide. Despite this profound impact, skin disease continues to receive relatively little attention in global health forums, and the etiology of most of these conditions is unclear. The skin is our major interface with the external world, densely innervated with sensory and autonomic nerve fibers. Thus, neuromodulators are involved during all phases of skin damage and healing. Nevertheless, we do not fully understand the interaction between skin innervation and skin pathologies. More importantly, the therapeutic potential contained in cutaneous innervation has not been exploited. NEUROSKIN will determine how different skin innervations affect psoriasis, a major skin disease, representing the largest class of skin conditions, those that are mediated by inflammation. We will utilize a transgenic mouse model that enables optogenetic control of local peripheral innervations using light. This model was developed as part of our ERC STG to characterize the involvement of peripheral innervation on gut inflammation. In NEUROSKIN, we will extend this tool to develop additional transgenic mice relevant to cutaneous neuronal subpopulations. In these mice, we will control the activity of neurons innervating the psoriatic plaques at different stages of the disease. This will allow us to map potential of targeted neuronal interventions to treat inflammatory skin conditions. Such characterization is expected to introduce an entire set of therapeutic tools based on neurological manipulations, and allow us to repurpose drugs and other technologies (e.g electrical and magnetic simulation) for the potential treatment of skin disorders. Moreover, NEUROSKIN will introduce a new toolbox that will enable the entire community to study the involvement of skin innervation in skin functions.

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The information about "NEUROSKIN" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-08-15 9:59:14) correctly updated