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DONNA SIGNED

Engineering de novo production of chlorinated polyketides in Pseudomonas putida

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DONNA project word cloud

Explore the words cloud of the DONNA project. It provides you a very rough idea of what is the project "DONNA" about.

environment    reprogrammed    white    biosustainability    pursue    polyketide    producing    molecules    platform    society    drug    selective    efficient    innovative    nature    chlorinated    background    environmentally    donna    analogues    pablo    biological    professional    re    industrial    ensures    synthetic    roadmap    model    kt2440    personal    modular    benefit    independent    complete    la    portfolio    microorganism    agrave    novo    economic    sustainable    synthetized    opportunity    progression    biology    synthesis    nordisk    solid    perspective    biosustain    reactions    cell    broad    synthases    smooth    organic    create    polyketides    biotechnology    engineering    nikel    clear    ideal    bio    channeled    win    foundation    dr    metabolic    factories    version    unbeatable    carry    fashion    chemistry    situation    genetic    precursors    bacterium    factored    carte    laboratory    supervision    scientific    researcher    center    rooted    halogenated    dtu    enzymes    compounds    extant    pseudomonas    myself    multiple    receiving    biocatalysts    competitiveness    putida    expert    economy    continue    biosynthesis   

Project "DONNA" data sheet

The following table provides information about the project.

Coordinator
DANMARKS TEKNISKE UNIVERSITET 

Organization address
address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A
city: KGS LYNGBY
postcode: 2800
website: www.dtu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 207˙312 €
 EC max contribution 207˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2022-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) coordinator 207˙312.00

Map

 Project objective

Sustainable economic development requires new biocatalysts to carry out novel, selective synthesis reactions in an environmentally-friendly fashion. Halogenated organic compounds, key products due to their multiple biological activities and industrial applications, continue to be produced via traditional chemistry and their efficient and cost-effective biosynthesis has not been yet achieved. In the present project, rooted in Metabolic Engineering and Synthetic Biology approaches, I will undertake a complete genetic and metabolic engineering of the model bacterium Pseudomonas putida KT2440 to create a platform for the bio-based production of chlorinated polyketides à la carte, which will contribute to the design of new drug analogues. I will establish and implement a clear roadmap from the extant bacterium to a re-factored version of the microorganism capable of efficiently producing chlorinated precursors, which will be channeled to the synthesis of new-to-nature chlorinated polyketides by reprogrammed modular polyketide synthases enzymes. Furthermore, the broad portfolio of halogenated molecules that can be synthetized with the cell factories from this project will contribute to the European knowledge-based bio-economy, enhance the EU's competitiveness in White Biotechnology and benefit the society as a whole. From a personal perspective, the implementation of this challenging and innovative project in The Novo Nordisk Foundation Center for Biosustainability (DTU Biosustain, the ideal scientific environment to pursue the tasks of DONNA), under the supervision of Dr. Pablo I. Nikel (an expert in the field of Metabolic Engineering of Pseudomonas), will be an unbeatable opportunity for both my professional and personal development. My solid scientific background, on the other hand, ensures a smooth progression as an independent researcher in the field of Metabolic Engineering that will result in a win-win situation for myself and the receiving laboratory.

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The information about "DONNA" are provided by the European Opendata Portal: CORDIS opendata.

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