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uKNEEversal SIGNED

uKNEEversal: a miniaturized 3D in vitro model of human joint to gain new knowledge on Osteoarthritis pathophysiology

Total Cost €

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EC-Contrib. €

0

Partnership

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 uKNEEversal project word cloud

Explore the words cloud of the uKNEEversal project. It provides you a very rough idea of what is the project "uKNEEversal" about.

poorly    clinical    environment    factually    mechanisms    ooc    animal    3d    poor    recapitulate    organ    symptoms    perspectives    3r    options    legislation    predictive    joint    compartments    basic    pushing    reverse    lack    culture    native    ukneeversal    vitro    fail    scalability    lacks    generation    tools    oa    organs    worldwide    pharma    cross    reflect    functions    molecular    claimed    model    pathology    chip    models    miniaturized    unable    linked    hardly    showed    enhanced    fill    alternative    generating    gap    pharmacological    limited    architecture    simplistic    degenerative    predicting    chips    macroscale    too    filling    transform    complexity    ground    achievable    obstacles    prevalent    animals    disability    sampling    sites    osteoarthritis    dissect    osteoarthritic    drug    breaking    therapies    reversing    diseases    scenario    recapitulating    miniaturization    2d    disease    function    human    accuracy    date    talks    regards   

Project "uKNEEversal" data sheet

The following table provides information about the project.

Coordinator
POLITECNICO DI MILANO 

Organization address
address: PIAZZA LEONARDO DA VINCI 32
city: MILANO
postcode: 20133
website: www.polimi.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 171˙473 €
 EC max contribution 171˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI MILANO IT (MILANO) coordinator 171˙473.00

Map

 Project objective

uKNEEversal aims at generating a comprehensive in vitro human model of Osteoarthritis (OA) to fill lacks of existing pre-clinical tools and open perspectives to investigate OA mechanisms and therapies. Degenerative joint diseases, among which OA is the most prevalent, represent the second cause of disability worldwide. Available pharmacological options are limited and focus on the reduction of symptoms, being unable to factually reverse the pathology. One of the major obstacles towards the development of disease-reversing therapies is the gap of knowledge on OA mechanisms, linked to the lack of reliable OA pre-clinical models. Existing pre-clinical tools are currently not able to dissect OA complexity in terms of cross talks among compartments and molecular pathways affected. Although animal models may offer a complex enough model, they often fail in predicting typical human responses and recent legislation about 3R principle is pushing Pharma towards methods alternative to animals. In this regards, one ground-breaking goal in the field is the generation of an OA model able to reflect the complexity of the disease in vitro. To date, most in vitro OA models, based on traditional 2D and macroscale culture systems, are affected by sampling sites, poor scalability, and are too simplistic to recapitulate joint 3D architecture. As an alternative, human organs-on-chips (OOC) have been claimed able to transform many areas of basic research and drug development. OOC are in vitro tools that can recapitulate a human organ’s function better than traditional culture systems, in a miniaturized environment. Miniaturization has indeed showed an enhanced control leading to in vitro models recapitulating the native organ functions with accuracy hardly achievable at the macroscale. In this scenario, uKNEEversal aims at filling the gap of existing poorly predictive pre-clinical models generating an in vitro human osteoarthritic joint model through organs-on-chip technology.

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The information about "UKNEEVERSAL" are provided by the European Opendata Portal: CORDIS opendata.

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