Opendata, web and dolomites

TargetGBM SIGNED

Generating a targeted, brain-permeable and stable polymeric nanoparticle for systemic gene delivery to glioblastoma

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 TargetGBM project word cloud

Explore the words cloud of the TargetGBM project. It provides you a very rough idea of what is the project "TargetGBM" about.

first    multiforme    cells    solid    toxic    labile    biological    code    drugs    patients    shown    incurable    viral    recurrent    screened    barriers    therapeutics    antibody    subsequently    gene    barrier    decrease    treatment    candidates    window    genetic    bbb    therapeutic    promise    mainly    mrna    potentially    die    efficient    cancer    oriented    encoding    expansion    protein    surviving    reaching    synthesis    systemic    nanoparticle    polyplex    recurrence    generate    acid    treat    enhances    deadly    tumours    tumour    variety    thereby    orientation    blood    dually    handles    stability    prevalent    internalization    released    permeability    vitro    model    tested    efficacy    mouse    chemistry    combination    chemical    designed    cell    efficiency    gbm    bioorthogonal    maximising    conditionally    transport    human    sheddable    brain    narrow    coating    transfection    modified    loaded    round    ligands    prevent    peptide    grow    glioblastoma    formulations   

Project "TargetGBM" data sheet

The following table provides information about the project.

Coordinator
INSTITUT QUIMIC DE SARRIA 

Organization address
address: CALLE VIA AUGUSTA 384-394
city: Barcelona
postcode: 8017
website: www.iqs.edu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 160˙932 €
 EC max contribution 160˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT QUIMIC DE SARRIA ES (Barcelona) coordinator 160˙932.00

Map

 Project objective

Glioblastoma multiforme (GBM) is the most prevalent deadly brain tumour and is currently incurable. Patients die from recurrent tumours that grow from cells surviving the first round of treatment. This is mainly due to the narrow therapeutic window of current drugs and to the low permeability of these drugs across the blood-brain barrier (BBB). Targeted non-viral delivery systems have shown great promise to decrease side effects of therapeutics and to enable the transport across biological barriers. The main objective in this proposal is to generate a dually targeted nanoparticle loaded with mRNA encoding a conditionally toxic protein to treat brain cancer. The nanoparticle will be modified with two ligands: an antibody for targeting tumour cells and a peptide that enables transport across the BBB. In addition, I will develop an acid-labile coating that enhances the stability of the polyplex in blood and is released upon internalization. This coating will present the ligands in a defined orientation using bioorthogonal chemistry, thereby maximising their targeting efficiency. The chemical handles will be introduced using genetic code expansion in the antibody and solid-phase synthesis in the peptide. A variety of formulations will be screened in vitro to evaluate their stability and transfection efficiency, and BBB permeability will be assessed in a human cell-based BBB model. Subsequently, the efficacy of the most promising candidates will be tested in a GBM mouse model. The combination of a polyplex having high transfection efficiency with a sheddable coating and oriented targeting ligands is designed to generate the first efficient non-viral gene delivery system for the systemic treatment of GBM, reaching all tumour cells to provide a more efficient treatment and potentially prevent recurrence.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TARGETGBM" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "TARGETGBM" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

CoCoNat (2019)

Coordination in constrained and natural distributed systems

Read More  

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

MegaBiCycle (2019)

The role of megafauna in biogeochemical cycles and greenhouse gas fluxes: implications for climate and ecosystems throughout history

Read More