Opendata, web and dolomites


Generating a targeted, brain-permeable and stable polymeric nanoparticle for systemic gene delivery to glioblastoma

Total Cost €


EC-Contrib. €






 TargetGBM project word cloud

Explore the words cloud of the TargetGBM project. It provides you a very rough idea of what is the project "TargetGBM" about.

glioblastoma    dually    solid    treatment    toxic    shown    peptide    internalization    protein    patients    subsequently    round    generate    polyplex    incurable    released    synthesis    reaching    acid    drugs    treat    therapeutics    cancer    brain    promise    first    prevent    model    efficiency    therapeutic    code    biological    narrow    maximising    efficacy    modified    candidates    screened    window    ligands    blood    cells    conditionally    tumours    deadly    thereby    vitro    labile    formulations    surviving    designed    efficient    mouse    prevalent    enhances    tumour    transfection    cell    handles    chemistry    human    recurrence    sheddable    bbb    variety    loaded    decrease    stability    mainly    tested    multiforme    mrna    grow    genetic    barrier    recurrent    bioorthogonal    potentially    viral    oriented    transport    nanoparticle    combination    coating    orientation    chemical    permeability    die    gbm    gene    expansion    systemic    encoding    antibody    barriers   

Project "TargetGBM" data sheet

The following table provides information about the project.


Organization address
address: CALLE VIA AUGUSTA 384-394
city: Barcelona
postcode: 8017

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 160˙932 €
 EC max contribution 160˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT QUIMIC DE SARRIA ES (Barcelona) coordinator 160˙932.00


 Project objective

Glioblastoma multiforme (GBM) is the most prevalent deadly brain tumour and is currently incurable. Patients die from recurrent tumours that grow from cells surviving the first round of treatment. This is mainly due to the narrow therapeutic window of current drugs and to the low permeability of these drugs across the blood-brain barrier (BBB). Targeted non-viral delivery systems have shown great promise to decrease side effects of therapeutics and to enable the transport across biological barriers. The main objective in this proposal is to generate a dually targeted nanoparticle loaded with mRNA encoding a conditionally toxic protein to treat brain cancer. The nanoparticle will be modified with two ligands: an antibody for targeting tumour cells and a peptide that enables transport across the BBB. In addition, I will develop an acid-labile coating that enhances the stability of the polyplex in blood and is released upon internalization. This coating will present the ligands in a defined orientation using bioorthogonal chemistry, thereby maximising their targeting efficiency. The chemical handles will be introduced using genetic code expansion in the antibody and solid-phase synthesis in the peptide. A variety of formulations will be screened in vitro to evaluate their stability and transfection efficiency, and BBB permeability will be assessed in a human cell-based BBB model. Subsequently, the efficacy of the most promising candidates will be tested in a GBM mouse model. The combination of a polyplex having high transfection efficiency with a sheddable coating and oriented targeting ligands is designed to generate the first efficient non-viral gene delivery system for the systemic treatment of GBM, reaching all tumour cells to provide a more efficient treatment and potentially prevent recurrence.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TARGETGBM" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "TARGETGBM" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

MingleIFT (2020)

Multi-color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of C. Elegans

Read More  

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More  

MathematicsAnalogies (2019)

Mathematics Analogies

Read More