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TargetGBM SIGNED

Generating a targeted, brain-permeable and stable polymeric nanoparticle for systemic gene delivery to glioblastoma

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TargetGBM project word cloud

Explore the words cloud of the TargetGBM project. It provides you a very rough idea of what is the project "TargetGBM" about.

first    orientation    drugs    internalization    barrier    cancer    treat    labile    biological    cell    systemic    encoding    glioblastoma    candidates    peptide    loaded    reaching    narrow    tested    human    handles    therapeutics    bbb    mouse    variety    viral    stability    gene    die    blood    round    generate    patients    permeability    subsequently    barriers    ligands    chemistry    cells    promise    gbm    efficacy    mainly    multiforme    expansion    chemical    brain    enhances    polyplex    screened    grow    incurable    acid    protein    thereby    model    tumours    recurrent    potentially    modified    combination    bioorthogonal    treatment    released    efficient    decrease    solid    mrna    conditionally    toxic    dually    designed    transfection    tumour    therapeutic    genetic    prevent    deadly    maximising    surviving    recurrence    window    vitro    prevalent    synthesis    coating    formulations    code    oriented    shown    nanoparticle    efficiency    transport    antibody    sheddable   

Project "TargetGBM" data sheet

The following table provides information about the project.

Coordinator
INSTITUT QUIMIC DE SARRIA 

Organization address
address: CALLE VIA AUGUSTA 384-394
city: Barcelona
postcode: 8017
website: www.iqs.edu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 160˙932 €
 EC max contribution 160˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT QUIMIC DE SARRIA ES (Barcelona) coordinator 160˙932.00

Map

 Project objective

Glioblastoma multiforme (GBM) is the most prevalent deadly brain tumour and is currently incurable. Patients die from recurrent tumours that grow from cells surviving the first round of treatment. This is mainly due to the narrow therapeutic window of current drugs and to the low permeability of these drugs across the blood-brain barrier (BBB). Targeted non-viral delivery systems have shown great promise to decrease side effects of therapeutics and to enable the transport across biological barriers. The main objective in this proposal is to generate a dually targeted nanoparticle loaded with mRNA encoding a conditionally toxic protein to treat brain cancer. The nanoparticle will be modified with two ligands: an antibody for targeting tumour cells and a peptide that enables transport across the BBB. In addition, I will develop an acid-labile coating that enhances the stability of the polyplex in blood and is released upon internalization. This coating will present the ligands in a defined orientation using bioorthogonal chemistry, thereby maximising their targeting efficiency. The chemical handles will be introduced using genetic code expansion in the antibody and solid-phase synthesis in the peptide. A variety of formulations will be screened in vitro to evaluate their stability and transfection efficiency, and BBB permeability will be assessed in a human cell-based BBB model. Subsequently, the efficacy of the most promising candidates will be tested in a GBM mouse model. The combination of a polyplex having high transfection efficiency with a sheddable coating and oriented targeting ligands is designed to generate the first efficient non-viral gene delivery system for the systemic treatment of GBM, reaching all tumour cells to provide a more efficient treatment and potentially prevent recurrence.

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The information about "TARGETGBM" are provided by the European Opendata Portal: CORDIS opendata.

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