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TargetGBM SIGNED

Generating a targeted, brain-permeable and stable polymeric nanoparticle for systemic gene delivery to glioblastoma

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TargetGBM project word cloud

Explore the words cloud of the TargetGBM project. It provides you a very rough idea of what is the project "TargetGBM" about.

sheddable    gene    efficiency    enhances    variety    prevalent    systemic    dually    surviving    genetic    toxic    internalization    stability    solid    decrease    recurrence    tested    transfection    incurable    candidates    conditionally    mouse    multiforme    encoding    oriented    potentially    subsequently    protein    tumour    window    generate    nanoparticle    maximising    reaching    chemical    efficacy    blood    mainly    prevent    shown    tumours    chemistry    combination    cancer    transport    designed    round    labile    bbb    viral    cells    vitro    barrier    ligands    model    formulations    code    patients    peptide    coating    recurrent    drugs    therapeutic    therapeutics    acid    thereby    first    synthesis    narrow    efficient    mrna    gbm    orientation    polyplex    promise    permeability    cell    glioblastoma    released    die    treat    screened    treatment    expansion    brain    handles    deadly    biological    bioorthogonal    antibody    barriers    modified    human    loaded    grow   

Project "TargetGBM" data sheet

The following table provides information about the project.

Coordinator
INSTITUT QUIMIC DE SARRIA 

Organization address
address: CALLE VIA AUGUSTA 384-394
city: Barcelona
postcode: 8017
website: www.iqs.edu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 160˙932 €
 EC max contribution 160˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT QUIMIC DE SARRIA ES (Barcelona) coordinator 160˙932.00

Map

 Project objective

Glioblastoma multiforme (GBM) is the most prevalent deadly brain tumour and is currently incurable. Patients die from recurrent tumours that grow from cells surviving the first round of treatment. This is mainly due to the narrow therapeutic window of current drugs and to the low permeability of these drugs across the blood-brain barrier (BBB). Targeted non-viral delivery systems have shown great promise to decrease side effects of therapeutics and to enable the transport across biological barriers. The main objective in this proposal is to generate a dually targeted nanoparticle loaded with mRNA encoding a conditionally toxic protein to treat brain cancer. The nanoparticle will be modified with two ligands: an antibody for targeting tumour cells and a peptide that enables transport across the BBB. In addition, I will develop an acid-labile coating that enhances the stability of the polyplex in blood and is released upon internalization. This coating will present the ligands in a defined orientation using bioorthogonal chemistry, thereby maximising their targeting efficiency. The chemical handles will be introduced using genetic code expansion in the antibody and solid-phase synthesis in the peptide. A variety of formulations will be screened in vitro to evaluate their stability and transfection efficiency, and BBB permeability will be assessed in a human cell-based BBB model. Subsequently, the efficacy of the most promising candidates will be tested in a GBM mouse model. The combination of a polyplex having high transfection efficiency with a sheddable coating and oriented targeting ligands is designed to generate the first efficient non-viral gene delivery system for the systemic treatment of GBM, reaching all tumour cells to provide a more efficient treatment and potentially prevent recurrence.

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The information about "TARGETGBM" are provided by the European Opendata Portal: CORDIS opendata.

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