Opendata, web and dolomites


"""Investigating autophagy enhancement as a therapeutic approach for the treatment of Rett syndrome."""

Total Cost €


EC-Contrib. €






 RTTOPHAGY project word cloud

Explore the words cloud of the RTTOPHAGY project. It provides you a very rough idea of what is the project "RTTOPHAGY" about.

alterations    cellular    involvement    accordance    macromolecules    sequesters    deficits    unknown    intellectual    incidence    aberrant    generalized    profoundly    linked    id    suggest    families    rtt    disorders    events    worldwide    synapses       disorder    neuronal    signaling    preliminary    altered    population    mainly    cells    molecular    defective    disease    ultimately    researcher    mental    cure    lesion    human    dysfunction    skills    cascade    organelles    providers    causing    clinical    participates    lives    group    dissect    degradation    capability    translated    caused    lysosomes    function    restore    neurological    autophagy    models    emerge    restoring    nerudevepmental    social    form    disability    synaptic    syndrome    individuals    mecp2    molecules    burden    transmission    data    mostly    10000    impaired    mutations    autophagosomes    prominent    neurodevelopmental    therapeutic    delivers    considerable    variety    samples    care    genetic    motor    treat    accordingly    therapeutics    health    severe    girls    devastating    approved    catabolic    rett   

Project "RTTOPHAGY" data sheet

The following table provides information about the project.


Organization address
address: VIA OLGETTINA 60
city: MILANO
postcode: 20132

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 171˙473 €
 EC max contribution 171˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2019
 Duration (year-month-day) from 2019-06-03   to  2021-06-16


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    OSPEDALE SAN RAFFAELE SRL IT (MILANO) coordinator 171˙473.00


 Project objective

Intellectual disability (ID) is a generalized neurodevelopmental disorder characterized by deficits in mental abilities, social and motor skills. ID affects about 2-3% of the general population and it is mostly caused by a genetic lesion. Accordingly, mutations in the X-linked MECP2 cause Rett syndrome (RTT), a devastating neurological disorder that, because of its incidence (1:10000), represents the most common form of severe ID in girls worldwide with no approved cure. RTT profoundly affect the lives of affected individuals and their families and represent a considerable burden for health care providers across Europe. While the molecular pathways causing RTT remain mainly unknown, it is recognized that they ultimately lead to prominent alterations of synaptic transmission and neuronal activity. Autophagy is a catabolic process that sequesters aberrant organelles and macromolecules into autophagosomes and delivers it to lysosomes for degradation. Autophagy participates in a variety of events in neuronal cells including synaptic growth and neuronal activity, however, its possible involvement in neurodevelopmental disorders is still mainly neglected. In accordance with a recent study applied to human samples, my preliminary data suggest that autophagy is altered in RTT. By using cellular models of the disease, this project aim at characterize the therapeutic potential of restoring the autophagy pathway in RTT. (i) I will dissect the defective autophagy signaling cascade; (ii) identify target molecules that restore the neuronal dysfunction and synapses transmission; (iii) provide therapeutic targets to treat RTT and other nerudevepmental disorders with impaired autophagy function. My results have the potential to be translated into therapeutics. This research will contribute to provide new clinical targets against RTT. The Experienced Researcher will emerge from the project with new skills, and the capability to lead her own research group.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "RTTOPHAGY" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "RTTOPHAGY" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

POMOC (2019)

Charles IV and the power of marvellous objects

Read More  

NPsVLCD (2019)

Natural Product-Inspired Therapies for Leishmaniasis and Chagas Disease

Read More  

GenEl (2020)

General readout electronics for cross-sectoral application in European research infrastructure

Read More