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SpheriCal

Reference Certification and Commercialisation of “Universal” Mass Spectrometry Calibration Standards

Total Cost €

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EC-Contrib. €

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Partnership

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 SpheriCal project word cloud

Explore the words cloud of the SpheriCal project. It provides you a very rough idea of what is the project "SpheriCal" about.

efficiency    economic    status    analytes    preliminary    synthetic    peak    false    certified    raw    clinical    ms    techniques    data    species    continuous    trials    material    clinically    environmental    pf    analytical    microbiology    benchmark    successful    fingerprint    biochemistry    preparation    drug    industries    regulatory    biomolecules    commercialize    validation    electrospray    medicine    components    resolution    reinforce    monitoring    prominence    technique    insufficient    spectrometers    bacterial    markets    biomedical    accurately    strict    standards    cutting    experiments    calibrants    reg    assignment    organic    regular    diagnostics    molecules    mass    polymers    spectrometry    poor    maldi    edge    positives    techno    small    cover    throughput    discovery    infection    spherical    6month    instrumentation    building    exhibits    bacteria    media    additional    nature    accurate    lack    calibration    consuming    confirm    disadvantages    drift    ionization    runs    misleading    miss    biological    attempting    esi    absolute    crm    im    lucrative    overcome    feasibility    recorded    time    limiting    critically    reference    shortcomings   

Project "SpheriCal" data sheet

The following table provides information about the project.

Coordinator
POLYMER FACTORY SWEDEN AB 

Organization address
address: TEKNIKRINGEN 48 1 TR
city: STOCKHOLM
postcode: 114 28
website: www.polymerfactory.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website https://www.polymerfactory.com/horizon-2020
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.3. (PRIORITY 'Societal challenges)
2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs)
3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
 Code Call H2020-SMEInst-2018-2020-1
 Funding Scheme SME-1
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2019-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLYMER FACTORY SWEDEN AB SE (STOCKHOLM) coordinator 50˙000.00

Map

 Project objective

Mass spectrometry (MS) is an established benchmark analytical technique to analyse biomolecules, organic molecules and synthetic polymers. MS techniques such as MALDI, IM-MS and ESI (electrospray ionization) are widely used in a range of fields such as biochemistry, clinical microbiology, medicine and drug discovery. Its prominence in these fields is due to the ability to accurately measure the absolute mass, and therefore species present, in complex analytes such as raw biological media, in high throughput experiments. For example, MALDI is used clinically to identify the nature of bacterial infection through the unique biological fingerprint of each bacteria type.

Critically, due to small and continuous changes in the various system components, data recorded exhibits a significant drift over time and between analysis runs, leading to peak miss-assignment and misleading data such as false positives. Therefore, mass spectrometers require regular calibration with a set of known standards in order to provide accurate and meaningful data. Without accurate calibration, MS instrumentation will not produce reliable data, limiting the advancement and efficiency of biomedical and clinical industries and environmental monitoring organizations. Existing calibrants have disadvantages such as time-consuming preparation, poor resolution, cover an insufficient mass range and lack Certified Reference Material (CRM) status.

To overcome these shortcomings of the existing calibrants, PF aim to commercialize a set of cutting-edge synthetic calibration standards called SpheriCal®. We are now attempting to reinforce SpheriCal® as a calibration system with CRM status – allowing access to additional lucrative markets such as clinical diagnostics and other markets with strict regulatory requirements.

Building upon successful development and validation through preliminary end-user trials, through this 6month Phase 1 project we aim to confirm the techno-economic feasibility of SpheriCal

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The information about "SPHERICAL" are provided by the European Opendata Portal: CORDIS opendata.

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