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Schwann Cell Options for chronic Pain Eradication

Total Cost €


EC-Contrib. €






 SCOPE project word cloud

Explore the words cloud of the SCOPE project. It provides you a very rough idea of what is the project "SCOPE" about.

population    oligodendrocytes    analgesics    medicines    pain    lineages    amplification    molecular    adult    receptor    sciatic    stress    allodynia    mice    unknown    brain    limited    rat    model    central    predictive    identification    nervous    channel    paracrine    primary    injured    neurons    observation    schwann    safety    message    cells    neuroinflammation    mild    tissue    medical    sensory    repertoire    inflammation    oxidative    sustains    neuropathic    transient    inflamed    chronic    safer    anticipate    subpopulation    neuropathies    human    cancer    sensitivity    treatment    nerve    unsatisfactory    enzymes    mouse    innocuous    extend    afflicts    cell    orchestrate    channels    ankyrin    inflammatory    efficacy    hitherto    biomarkers    ensheath    models    prototypical    paradigm    eligible    signalling    stimuli    susceptibility    peripheral    transducer    ligation    analgesic    trpa1    combine    entails    exerts    nociceptors    biosignatures    expressed    acute    autocrine    25    purpose    discovered    discovering    sustain    fibres   

Project "SCOPE" data sheet

The following table provides information about the project.


Organization address
address: Piazza San Marco 4
city: Florence
postcode: 50121

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 2˙185˙921 €
 EC max contribution 2˙185˙921 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2024-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI FIRENZE IT (Florence) coordinator 2˙185˙921.00


 Project objective

Chronic pain, characterized by increased sensitivity to innocuous/mild stimuli (allodynia), afflicts 25% of the European adult population. Efficacy and/or safety of analgesic medicines is limited, and the treatment of chronic pain associated with inflammation, peripheral and central neuropathies and cancer remains unsatisfactory. Thus, identification of novel targets for better and safer analgesics is a major medical need. Transient receptor potential ankyrin 1 (TRPA1) channel, expressed by a subpopulation of primary sensory neurons (nociceptors), has been proposed as a major transducer of acute pain. We have, recently, identified that TRPA1 is expressed in Schwann cells that ensheath peripheral nerve fibres. In a prototypical model of neuropathic pain (sciatic nerve ligation in mice), we discovered that Schwann cell-TRPA1 exerts a hitherto unknown role that, via amplification of the oxidative stress message, sustains neuroinflammation and chronic pain (allodynia). Thus, Schwann cells, through their own repertoire of channels and enzymes orchestrate in the injured/inflamed tissue an autocrine/paracrine signalling pathway to sustain chronic pain. The purpose of the present project is to extend this observation to other models of inflammatory, neuropathic and cancer pain to identify a general paradigm based on Schwann cell/TRPA1/oxidative stress as the pathway that sustains chronic pain. We aim also at identifying in oligodendrocytes (the Schwann cells of the brain) whether the TRPA1/oxidative stress pathway sustains pain in the central nervous system. In mouse, rat and human Schwann cells/oligodendrocytes we aim at identifying biomarkers and combine them into biosignatures predictive of the susceptibility to the development of chronic pain. We anticipate that each molecular step that entails the TRPA1/oxidative stress pathway in Schwann cell lineages is an eligible target for discovering new effective and safer medicines for the treatment of chronic pain.

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The information about "SCOPE" are provided by the European Opendata Portal: CORDIS opendata.

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