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SCOPE SIGNED

Schwann Cell Options for chronic Pain Eradication

Total Cost €

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EC-Contrib. €

0

Partnership

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 SCOPE project word cloud

Explore the words cloud of the SCOPE project. It provides you a very rough idea of what is the project "SCOPE" about.

cancer    ensheath    paradigm    allodynia    25    neuropathies    central    extend    ankyrin    mouse    inflammation    autocrine    mild    analgesics    afflicts    cell    model    safer    hitherto    nervous    medicines    neuroinflammation    discovering    stimuli    nerve    chronic    channels    mice    trpa1    inflammatory    human    tissue    exerts    amplification    molecular    signalling    innocuous    stress    fibres    receptor    identification    pain    observation    efficacy    treatment    sciatic    subpopulation    discovered    primary    transducer    anticipate    purpose    lineages    inflamed    neurons    brain    prototypical    acute    safety    entails    medical    cells    expressed    models    sensory    nociceptors    eligible    injured    predictive    unsatisfactory    orchestrate    rat    biosignatures    sustain    channel    repertoire    peripheral    paracrine    oxidative    oligodendrocytes    unknown    schwann    sustains    ligation    enzymes    biomarkers    analgesic    neuropathic    combine    susceptibility    message    adult    population    transient    limited    sensitivity   

Project "SCOPE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI FIRENZE 

Organization address
address: Piazza San Marco 4
city: Florence
postcode: 50121
website: http://www.unifi.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 2˙185˙921 €
 EC max contribution 2˙185˙921 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2024-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI FIRENZE IT (Florence) coordinator 2˙185˙921.00

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 Project objective

Chronic pain, characterized by increased sensitivity to innocuous/mild stimuli (allodynia), afflicts 25% of the European adult population. Efficacy and/or safety of analgesic medicines is limited, and the treatment of chronic pain associated with inflammation, peripheral and central neuropathies and cancer remains unsatisfactory. Thus, identification of novel targets for better and safer analgesics is a major medical need. Transient receptor potential ankyrin 1 (TRPA1) channel, expressed by a subpopulation of primary sensory neurons (nociceptors), has been proposed as a major transducer of acute pain. We have, recently, identified that TRPA1 is expressed in Schwann cells that ensheath peripheral nerve fibres. In a prototypical model of neuropathic pain (sciatic nerve ligation in mice), we discovered that Schwann cell-TRPA1 exerts a hitherto unknown role that, via amplification of the oxidative stress message, sustains neuroinflammation and chronic pain (allodynia). Thus, Schwann cells, through their own repertoire of channels and enzymes orchestrate in the injured/inflamed tissue an autocrine/paracrine signalling pathway to sustain chronic pain. The purpose of the present project is to extend this observation to other models of inflammatory, neuropathic and cancer pain to identify a general paradigm based on Schwann cell/TRPA1/oxidative stress as the pathway that sustains chronic pain. We aim also at identifying in oligodendrocytes (the Schwann cells of the brain) whether the TRPA1/oxidative stress pathway sustains pain in the central nervous system. In mouse, rat and human Schwann cells/oligodendrocytes we aim at identifying biomarkers and combine them into biosignatures predictive of the susceptibility to the development of chronic pain. We anticipate that each molecular step that entails the TRPA1/oxidative stress pathway in Schwann cell lineages is an eligible target for discovering new effective and safer medicines for the treatment of chronic pain.

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The information about "SCOPE" are provided by the European Opendata Portal: CORDIS opendata.

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