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Schwann Cell Options for chronic Pain Eradication

Total Cost €


EC-Contrib. €






 SCOPE project word cloud

Explore the words cloud of the SCOPE project. It provides you a very rough idea of what is the project "SCOPE" about.

mice    medicines    purpose    tissue    subpopulation    cell    safety    combine    stress    pain    acute    peripheral    ligation    channels    rat    nociceptors    innocuous    biomarkers    mild    cells    25    sustain    ankyrin    repertoire    allodynia    efficacy    cancer    exerts    neurons    discovering    molecular    sustains    message    orchestrate    model    mouse    stimuli    susceptibility    schwann    sciatic    oligodendrocytes    eligible    observation    sensory    lineages    channel    injured    afflicts    paradigm    expressed    brain    unknown    population    adult    chronic    nerve    sensitivity    limited    autocrine    ensheath    nervous    hitherto    analgesic    identification    entails    oxidative    analgesics    medical    central    biosignatures    neuropathic    paracrine    enzymes    inflamed    discovered    amplification    receptor    models    neuropathies    inflammation    transducer    unsatisfactory    anticipate    transient    trpa1    primary    treatment    prototypical    human    signalling    neuroinflammation    safer    extend    fibres    inflammatory    predictive   

Project "SCOPE" data sheet

The following table provides information about the project.


Organization address
address: Piazza San Marco 4
city: Florence
postcode: 50121

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 2˙185˙921 €
 EC max contribution 2˙185˙921 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2024-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI FIRENZE IT (Florence) coordinator 2˙185˙921.00


 Project objective

Chronic pain, characterized by increased sensitivity to innocuous/mild stimuli (allodynia), afflicts 25% of the European adult population. Efficacy and/or safety of analgesic medicines is limited, and the treatment of chronic pain associated with inflammation, peripheral and central neuropathies and cancer remains unsatisfactory. Thus, identification of novel targets for better and safer analgesics is a major medical need. Transient receptor potential ankyrin 1 (TRPA1) channel, expressed by a subpopulation of primary sensory neurons (nociceptors), has been proposed as a major transducer of acute pain. We have, recently, identified that TRPA1 is expressed in Schwann cells that ensheath peripheral nerve fibres. In a prototypical model of neuropathic pain (sciatic nerve ligation in mice), we discovered that Schwann cell-TRPA1 exerts a hitherto unknown role that, via amplification of the oxidative stress message, sustains neuroinflammation and chronic pain (allodynia). Thus, Schwann cells, through their own repertoire of channels and enzymes orchestrate in the injured/inflamed tissue an autocrine/paracrine signalling pathway to sustain chronic pain. The purpose of the present project is to extend this observation to other models of inflammatory, neuropathic and cancer pain to identify a general paradigm based on Schwann cell/TRPA1/oxidative stress as the pathway that sustains chronic pain. We aim also at identifying in oligodendrocytes (the Schwann cells of the brain) whether the TRPA1/oxidative stress pathway sustains pain in the central nervous system. In mouse, rat and human Schwann cells/oligodendrocytes we aim at identifying biomarkers and combine them into biosignatures predictive of the susceptibility to the development of chronic pain. We anticipate that each molecular step that entails the TRPA1/oxidative stress pathway in Schwann cell lineages is an eligible target for discovering new effective and safer medicines for the treatment of chronic pain.

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The information about "SCOPE" are provided by the European Opendata Portal: CORDIS opendata.

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