Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. alco-ado

ALCO-ADO SIGNED

Unveiling the alcohol-dependent alterations in local dendritic translation of mRNAs in the prefrontal cortex during adolescence

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ALCO-ADO project word cloud

Explore the words cloud of the ALCO-ADO project. It provides you a very rough idea of what is the project "ALCO-ADO" about.

frontal    maturation    functions    cortex    memory    maladaptive    eif2    connections    alpha    males    mesocorticolimbic    proteins    behavioral    defects    tests    poorly    usurps    translation    shown    mrnas    mtorc1    populations    glutamatergic    drugs    biochemistry    intense    drug    local    adolescents    multidisciplinary    synaptic    excessive    alterations    impairs    brain    molecular    analyze    deleterious    modifies    altered    heightened    function    neurocognitive    regions    female    during    neuronal    impulsivity    electrophysiology    differential    mainly    mice    male    gabaergic    plasticity    neurons    involvement    adolescent    profoundly    dependent    implicated    undergoes    interneurons    adolescence    combining    modulates    modifications    behaviors    underlying    addiction    prefrontal    executive    pfc    consumption    females    learning    translatome    alcohol    mechanisms    precise    imaging    composition    defective    form    lasting    sites    uncover    psychological    strength    sensibility    differences    immaturity    regulators    modulating    vulnerability   

Project "ALCO-ADO" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITE DE LIEGE 

Organization address
address: PLACE DU 20 AOUT 7
city: LIEGE
postcode: 4000
website: www.ulg.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Belgium [BE]
 Total cost 178˙320 €
 EC max contribution 178˙320 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LIEGE BE (LIEGE) coordinator 178˙320.00

Map

 Project objective

During adolescence, the brain undergoes intense maturation, particularly in the frontal areas. The prefrontal cortex (PFC) is implicated in executive functions, and its immaturity in adolescents is associated with increased impulsivity and heightened vulnerability to deleterious effects of drugs. Alcohol is the most consumed drug among adolescents, and its excessive consumption profoundly impairs PFC function, leading to long-lasting defective behaviors, psychological problems and neurocognitive defects. However, the precise mechanisms underlying alcohol-induced alterations in PFC maturation remain poorly understood. Alcohol addiction is considered being a maladaptive form of learning and memory, as alcohol usurps the molecular mechanisms underlying those processes, such as long-lasting synaptic plasticity. Long-lasting changes in the strength of synaptic connections mainly depend on the local translation of mRNAs at synaptic sites. It has been shown that alcohol modifies synaptic proteins composition by modulating the activity of key translation regulators, such as mTORC1 and eIF2α, in brain regions associated with the mesocorticolimbic pathway. Here, we propose to analyze the alcohol-dependent modifications of the synaptic translatome of specific neuronal populations (glutamatergic neurons and GABAergic interneurons) in the PFC of adolescent male and female mice, by using a multidisciplinary approach combining biochemistry, imaging, electrophysiology and behavioral tests. This project aims to uncover how alcohol modulates local translation of synaptic proteins in the PFC during adolescence, to identify the targeted synaptic mRNAs and analyze their involvement in altered synaptic plasticity underlying alcohol-dependent defective behaviors. In addition, this project aims at identifying the differential sensibility to alcohol’s effects between males and females as well as the differences in behavioral consequences.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ALCO-ADO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ALCO-ADO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

SAInTHz (2020)

Structuration of aqueous interfaces by Terahertz pulses: A study by Second Harmonic and Sum Frequency Generation

Read More  

LiverMacRegenCircuit (2020)

Elucidating the role of macrophages in liver regeneration and tissue unit formation

Read More  

TheaTheor (2018)

Theorizing the Production of 'Comedia Nueva': The Process of Play Configuration in Spanish Golden Age Theater

Read More