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PHOTO-WALK SIGNED

Metal-catalyzed remote functionalization of aliphatic amines and amides triggered by photocatalytic sp3 C-H activation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PHOTO-WALK project word cloud

Explore the words cloud of the PHOTO-WALK project. It provides you a very rough idea of what is the project "PHOTO-WALK" about.

ni    corresponding    merge    metal    benzylic    event    limitations    aliphatic    transformation    largely    unactivated    molecular    opportunity    drug    transformations    exploration    derivatization    chain    envisioned    bearing    pharmaceuticals    stage    heteroatom    forging    isomerization    arylation    hydrocarbon    chemical    sp2    molecules    structural    uncharted    catalytic    decades    diversification    photo    strategies    walk    limited    positions    disclosing    strategy    handles    carboxylation    group    ch    allylic    respect    manipulation    bonds    transition    sp3    olefin    lacking    overcome    functionalization    unreachable    last    employing    alkylation    alkyl    directing    amines    photocatalysis    discovery    outstanding    walking    catalyzed    spaces    activation    halide    emerged    sites    confined    functionalizations    complexity    tool    impressive    advancements    feedstocks    attracted    remote    amides    inert    prefunctionalized    photocatalytic    bromide    activated    completely   

Project "PHOTO-WALK" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA 

Organization address
address: AVENIDA PAISSOS CATALANS 16
city: TARRAGONA
postcode: 43007
website: www.iciq.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 160˙932 €
 EC max contribution 160˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-02-03   to  2022-05-05

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA ES (TARRAGONA) coordinator 160˙932.00

Map

 Project objective

Activation of traditionally inert bonds has attracted great attention in the last decades and impressive advancements have been achieved in the catalytic functionalization of CH bonds. Although the great number of catalytic methodologies for the transformation at sp2 CH sites, manipulation of the corresponding sp3 CH bonds remains largely confined to activated allylic and benzylic positions or to sites within reach of an existing directing group. Transition metal-catalyzed olefin isomerization has provided an outstanding tool for remote functionalization of sp3 CH bonds but it requires the use of prefunctionalized molecules, bearing a component or an alkyl bromide. On the other hand, photocatalysis has emerged as a novel strategy for sp3 CH activation but it is limited to the functionalization at the or positions with respect to a heteroatom. PHOTO-WALK will merge the photocatalytic activation of sp3 CH bonds with a Ni-catalyzed chain-walking process, disclosing a completely novel triggering event for the remote functionalization of unactivated aliphatic amines and amides. The approach will overcome the limitations of current strategies for remote functionalization, allowing transformations at sp3 CH sites unreachable by current photocatalytic methods and employing hydrocarbon feedstocks (aliphatic amines and amides) lacking of C=C or C-halide handles. Three functionalizations have been envisioned to increase molecular complexity by forging new C(sp2)–C(sp3) and C(sp3)–C(sp3) bonds: i) remote carboxylation, ii) remote arylation and iii) remote alkylation. PHOTO-WALK has the potential to be applied to the late-stage derivatization of pharmaceuticals, enabling the exploration of uncharted chemical spaces and offering the opportunity for structural diversification in drug discovery.

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The information about "PHOTO-WALK" are provided by the European Opendata Portal: CORDIS opendata.

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