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PHOTO-WALK SIGNED

Metal-catalyzed remote functionalization of aliphatic amines and amides triggered by photocatalytic sp3 C-H activation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PHOTO-WALK project word cloud

Explore the words cloud of the PHOTO-WALK project. It provides you a very rough idea of what is the project "PHOTO-WALK" about.

largely    overcome    corresponding    last    outstanding    diversification    derivatization    chain    directing    envisioned    amides    stage    allylic    discovery    amines    uncharted    confined    attracted    structural    molecular    sp2    respect    metal    halide    molecules    heteroatom    decades    benzylic    spaces    unreachable    prefunctionalized    walk    drug    photo    ni    carboxylation    positions    activation    olefin    event    inert    strategies    transformation    handles    lacking    functionalizations    activated    arylation    completely    transition    feedstocks    advancements    functionalization    group    hydrocarbon    tool    merge    photocatalysis    impressive    chemical    pharmaceuticals    alkyl    sites    transformations    disclosing    remote    isomerization    manipulation    catalytic    exploration    limited    bonds    limitations    employing    forging    aliphatic    bearing    walking    emerged    sp3    ch    strategy    opportunity    alkylation    catalyzed    complexity    unactivated    photocatalytic    bromide   

Project "PHOTO-WALK" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA 

Organization address
address: AVENIDA PAISSOS CATALANS 16
city: TARRAGONA
postcode: 43007
website: www.iciq.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 160˙932 €
 EC max contribution 160˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-02-03   to  2022-05-05

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA ES (TARRAGONA) coordinator 160˙932.00

Map

 Project objective

Activation of traditionally inert bonds has attracted great attention in the last decades and impressive advancements have been achieved in the catalytic functionalization of CH bonds. Although the great number of catalytic methodologies for the transformation at sp2 CH sites, manipulation of the corresponding sp3 CH bonds remains largely confined to activated allylic and benzylic positions or to sites within reach of an existing directing group. Transition metal-catalyzed olefin isomerization has provided an outstanding tool for remote functionalization of sp3 CH bonds but it requires the use of prefunctionalized molecules, bearing a component or an alkyl bromide. On the other hand, photocatalysis has emerged as a novel strategy for sp3 CH activation but it is limited to the functionalization at the or positions with respect to a heteroatom. PHOTO-WALK will merge the photocatalytic activation of sp3 CH bonds with a Ni-catalyzed chain-walking process, disclosing a completely novel triggering event for the remote functionalization of unactivated aliphatic amines and amides. The approach will overcome the limitations of current strategies for remote functionalization, allowing transformations at sp3 CH sites unreachable by current photocatalytic methods and employing hydrocarbon feedstocks (aliphatic amines and amides) lacking of C=C or C-halide handles. Three functionalizations have been envisioned to increase molecular complexity by forging new C(sp2)–C(sp3) and C(sp3)–C(sp3) bonds: i) remote carboxylation, ii) remote arylation and iii) remote alkylation. PHOTO-WALK has the potential to be applied to the late-stage derivatization of pharmaceuticals, enabling the exploration of uncharted chemical spaces and offering the opportunity for structural diversification in drug discovery.

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The information about "PHOTO-WALK" are provided by the European Opendata Portal: CORDIS opendata.

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