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RECON SIGNED

Reprogramming Conformation by Fluorination: Exploring New Areas of Chemical Space

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 RECON project word cloud

Explore the words cloud of the RECON project. It provides you a very rough idea of what is the project "RECON" about.

compounds    function    materials    bio    substitution    architectures    history    nature    achiral    limitation    pharmaceuticals    molecules    perfluorination    progress    medicine    commercially    optically    dimensional    stereochemical    aryl    compromise    units    site    space    substrate    scaffolds    disparity    consequently    moieties    venerable    medicinal    agrochemicals    rationally    striking    stereochemically    paucity    agrochemistry    12    largely    inspection    compromises    confirms    uncharted    construction    fluorides    oxidation    patterns    reflects    extremes    chiral    fluorine    enantiopurity    2d    competing    platform    material    synthesis    synthetic    lack    closer    predominantly    contain    substituents    functionalisation    efficiency    elimination    structural    accelerate    occurring    single    multiply    reveals    modular    discovery    40    deoxyfluorination    despite    sp3    starting    functional    confined    chemical    sciences    active    fluorination    magnified    fluorinated    recon    abundance    3d    place    feedstock    organic    generation    scenario    preparing    enormous    sources    basis    fluoride    contrast    exploration    molecule    organofluorine    inexpensive    naturally   

Project "RECON" data sheet

The following table provides information about the project.

Coordinator
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER 

Organization address
address: SCHLOSSPLATZ 2
city: MUENSTER
postcode: 48149
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙999˙375 €
 EC max contribution 1˙999˙375 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER DE (MUENSTER) coordinator 1˙999˙375.00

Map

 Project objective

Despite the abundance of organic compounds in Nature, only 12 contain fluorine. In contrast, fluorinated organic materials account for over 40% of all pharmaceuticals and agrochemicals. Closer inspection of the fluorination patterns in these functional molecules reveals striking extremes towards perfluorination (in both 2D and 3D scaffolds) or single site fluorination predominantly in aryl substituents. Consequently, most fluorinated moieties in functional materials lack stereochemical information and are thus achiral. This disparity between the paucity of naturally occurring organofluorine compounds and their venerable history in functional molecule design confirms the enormous potential of fluorinated materials in the discovery of novel properties. That progress has largely been confined to 3 dimensional achiral and 2 dimensional achiral architectures reflects the synthetic challenges associated with preparing stereochemical defined multiply fluorinated systems. A major limitation in the construction of C(sp3)-F units remains the need for substrate pre-functionalisation via oxidation and the competing substitution/elimination scenario that compromises efficiency in the deoxyfluorination. This problem is magnified in the synthesis of optically active fluorides where the deoxyfluorination can compromise the enantiopurity of the starting materials. The principle aim of RECON is to facilitate exploration of 3D, chiral space by providing access to multiply fluorinated, stereochemically complex organofluorine materials from simple feedstock using inexpensive, commercially available fluoride sources. In providing a modular platform to rationally place function on a structural basis, exploration of uncharted chemical space will accelerate the discovery of next generation materials for medicinal and agrochemistry, material sciences and bio-medicine.

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The information about "RECON" are provided by the European Opendata Portal: CORDIS opendata.

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