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RECON SIGNED

Reprogramming Conformation by Fluorination: Exploring New Areas of Chemical Space

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 RECON project word cloud

Explore the words cloud of the RECON project. It provides you a very rough idea of what is the project "RECON" about.

fluorides    venerable    fluoride    history    bio    progress    molecule    structural    predominantly    organofluorine    closer    compounds    material    elimination    perfluorination    compromise    stereochemical    limitation    compromises    accelerate    starting    striking    oxidation    fluorine    molecules    substitution    basis    feedstock    fluorination    modular    nature    scaffolds    reveals    site    12    construction    efficiency    dimensional    inexpensive    architectures    materials    extremes    paucity    uncharted    recon    medicine    functionalisation    magnified    synthetic    sciences    synthesis    single    40    abundance    space    stereochemically    fluorinated    aryl    moieties    place    despite    2d    consequently    enormous    functional    naturally    achiral    sp3    multiply    platform    agrochemicals    patterns    reflects    3d    active    lack    chemical    confined    commercially    occurring    optically    chiral    largely    confirms    generation    agrochemistry    inspection    exploration    organic    contain    contrast    scenario    substrate    medicinal    units    discovery    deoxyfluorination    sources    function    enantiopurity    pharmaceuticals    disparity    preparing    rationally    competing    substituents   

Project "RECON" data sheet

The following table provides information about the project.

Coordinator
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER 

Organization address
address: SCHLOSSPLATZ 2
city: MUENSTER
postcode: 48149
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙999˙375 €
 EC max contribution 1˙999˙375 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER DE (MUENSTER) coordinator 1˙999˙375.00

Map

 Project objective

Despite the abundance of organic compounds in Nature, only 12 contain fluorine. In contrast, fluorinated organic materials account for over 40% of all pharmaceuticals and agrochemicals. Closer inspection of the fluorination patterns in these functional molecules reveals striking extremes towards perfluorination (in both 2D and 3D scaffolds) or single site fluorination predominantly in aryl substituents. Consequently, most fluorinated moieties in functional materials lack stereochemical information and are thus achiral. This disparity between the paucity of naturally occurring organofluorine compounds and their venerable history in functional molecule design confirms the enormous potential of fluorinated materials in the discovery of novel properties. That progress has largely been confined to 3 dimensional achiral and 2 dimensional achiral architectures reflects the synthetic challenges associated with preparing stereochemical defined multiply fluorinated systems. A major limitation in the construction of C(sp3)-F units remains the need for substrate pre-functionalisation via oxidation and the competing substitution/elimination scenario that compromises efficiency in the deoxyfluorination. This problem is magnified in the synthesis of optically active fluorides where the deoxyfluorination can compromise the enantiopurity of the starting materials. The principle aim of RECON is to facilitate exploration of 3D, chiral space by providing access to multiply fluorinated, stereochemically complex organofluorine materials from simple feedstock using inexpensive, commercially available fluoride sources. In providing a modular platform to rationally place function on a structural basis, exploration of uncharted chemical space will accelerate the discovery of next generation materials for medicinal and agrochemistry, material sciences and bio-medicine.

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The information about "RECON" are provided by the European Opendata Portal: CORDIS opendata.

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