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BioPhoCS SIGNED

Bio- & Photo-Catalytic Methods for the Construction of Enantiomerically Pure C-S Bonds in Thiols and Sulphides

Total Cost €

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EC-Contrib. €

0

Partnership

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 BioPhoCS project word cloud

Explore the words cloud of the BioPhoCS project. It provides you a very rough idea of what is the project "BioPhoCS" about.

tools    chemistry    photo    assembling    pot    chemists    containing    designed    flavouring    stereoselective    thiols    strategies    chemicals    pure    adh    asymmetrical    enantiopure    configurations    agrochemicals    penicillins    mechanisms    substrates    catalysts    chiral    thioketones    construct    biocatalysis    bonds    sustainable    odorous    absolute    ligands    enantioselective    cascade    synthesis    pharmaceutical    light    flavours    combination    successful    chemical    reactions    sulphides    kred    biocatalytic    kinetic    sulphur    green    reductase    photocatalytic    manufacturing    compounds    efficient    intriguing    ered    blue    will    enzymes    industries    classes    photocatalysis    lack    nmr    organic    ubiquitous    bio    fragrances    situ    construction    excipients    olfactory    centres    natural    view    catalysis    peculiar    conferred    reaction    ingredients    verticillins    facile    biocatalyse    fine    volatile    thioalkenes    enantiomerically    determined    prepare   

Project "BioPhoCS" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 224˙933.00

Map

 Project objective

Organic sulphur compounds containing C-S chiral centres represent one of the most intriguing classes of chemicals due to their peculiar properties conferred by the unique chemistry of sulphur. Chiral sulphur compounds are known for their olfactory properties as flavours and fragrances and are ubiquitous in natural products and pharmaceutical ingredients such as penicillins and verticillins. Both the flavouring and pharmaceutical properties of chiral sulphur compounds are often determined by their absolute configurations. Therefore, the development of novel, robust and sustainable methods for the enantioselective construction of C-S bonds is of great importance in chemistry. In view of the lack of efficient and stereoselective methods in assembling asymmetrical C-S bonds, within this project we aim to construct enantiopure sulphur compounds through photo- and bio-catalysis. Various strategies have been designed to achieve this target, exploiting blue/green light photocatalysis and biocatalysis by reductase enzymes such as KRED, ADH and ERED. The ability of these enzymes to biocatalyse the enantioselective reduction of thioketones and thioalkenes obtained via photocatalysis, will be investigated. In addition, the combination of photocatalytic synthesis of substrates with the biocatalytic construction of enantiomerically pure C-S bonds in one-pot cascade processes will be developed. These methods will be finally applied to the synthesis of chiral volatile sulphur compounds as odorous excipients, while in-situ NMR kinetic studies of the photo-biocatalytic reactions will be carried out to get a better understanding of the reaction mechanisms. The successful development of these strategies will allow chemists and industries to access facile and sustainable approaches to prepare a wide range of challenging chiral thiols and sulphides to be used in the manufacturing of pharmaceutical ingredients, fine chemical tools (ligands, catalysts), agrochemicals and fragrances.

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