Explore the words cloud of the GWAS2FUNC project. It provides you a very rough idea of what is the project "GWAS2FUNC" about.
The following table provides information about the project.
|Coordinator Country||Netherlands [NL]|
|Total cost||2˙378˙412 €|
|EC max contribution||2˙378˙412 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2019-09-01 to 2024-08-31|
Take a look of project's partnership.
Genome-wide association studies (GWAS) of unprecedented sample size have recently provided robust insight into the polygenic architecture of many different brain disorders. Despite this exciting potential, GWAS results have rarely translated into mechanistic disease insight. This is because the detected genetic effects are small and numerous, and hardly ever directly actionable for functional follow-up. In addition, the polygenic nature of brain disorders comes with large genetic heterogeneity, where different patients with the same disorder may carry completely different combinations of genetic risk variants, possibly corresponding to different etiological mechanisms, requiring different treatment regimens. To benefit from GWAS, extensive biological interpretation and insight into genetic heterogeneity is needed. In this ERC I will develop much needed tools for (i) extensive biological interpretation at cellular resolution and (ii) assessing genetic heterogeneity, both aimed at formulating hypotheses that take into account the polygenic nature of brain disorders and can be tested in functional experiments. I will apply the developed tools to a wide range of brain-related traits, providing ample starting points for functional follow-up. As a proof-of-concept I will test the viability of two neuroscientific approaches (iPSC and DREADDs) for functional follow-up of GWAS results. First, I will conduct scRNA sequencing and electrophysiological assessments on iPSC derived neurons and astrocytes from genetically selected (schizophrenia) patients and controls. Second, I will use in vivo chemogenetic manipulation to target specific cell types that have been implicated by GWAS (for insomnia). The primary goal of this proposal is to bridge the gap between GWAS and function. The results will facilitate the translation of GWAS findings for brain disorders into functional mechanisms that are biologically important in disease pathogenesis and, ultimately, treatment design.
|Data Management Plan||Open Research Data Pilot||2020-03-13 11:16:08|
Take a look to the deliverables list in detail: detailed list of GWAS2FUNC deliverables.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GWAS2FUNC" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (email@example.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "GWAS2FUNC" are provided by the European Opendata Portal: CORDIS opendata.
Towards Realistic Modelling of Nucleosome Organization Inside Functional Chromatin DomainsRead More
Overcoming cellular barriers to therapeutic RNA delivery using extracellular vesiclesRead More
High throughput multiplexed trace-analyte screening for diagnostics applicationsRead More