Opendata, web and dolomites

Cryo-SECOM Workflow SIGNED

Unlocking the potential of cryo-electron tomography by simplification of the sample preparation workflow

Total Cost €


EC-Contrib. €






 Cryo-SECOM Workflow project word cloud

Explore the words cloud of the Cryo-SECOM Workflow project. It provides you a very rough idea of what is the project "Cryo-SECOM Workflow" about.

unusable    90    handling    extreme    automating    structure    expensive    imaging    manual    cells    trying    vision    80    fold    tremendously    delmic    resolve    ultimate    robot    nobel    costly    phd    biology    tie    microscopy    fulfil    unprecedented    electron    samples    time    yield    microscope    chemistry    prize    reduces    additionally    tertiary    secom    fast    innovate    22    em    completely    opening    cheap    precision    operator    light    area    decreasing    87    integrates    wasted    correlated    et    switching    complexity    performed    protein    image    full    preparation    tomography    sem    basically    automatized    reducing    reimagined    cryo    loading    hours    unified    biological    carrier    faster    incredibly    unlocking    simplifies    bottleneck    quaternary    prep    fib    structural    central    placing    gives    workflow    tems    unloading    horizons    workstations    interactions    bacteria    offers    2017    simplifying    gt   

Project "Cryo-SECOM Workflow" data sheet

The following table provides information about the project.


Organization address
address: KANAALWEG 4
city: DELFT
postcode: 2628EB
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 3˙062˙500 €
 EC max contribution 2˙143˙750 € (70%)
 Programme 1. H2020-EU.3. (PRIORITY 'Societal challenges)
2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs)
3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
 Code Call H2020-SMEInst-2018-2020-2
 Funding Scheme SME-2
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DELMIC BV NL (DELFT) coordinator 2˙143˙750.00


 Project objective

'The interest for cryo electron microscopy (cryo-EM) has risen tremendously since the Nobel Prize in Chemistry 2017 was given for Cryo-EM. The next step in Cryo EM, Cryo Electron Tomography (cryo-ET), makes it possible to resolve tertiary and quaternary protein structure interactions in relevant biological samples such as cells and bacteria. However, in the current cryo-ET workflow the sample preparation is the bottleneck. Today, sample preparation is a manual process of 4-8 hours, involves 22 steps and is performed by a PhD level operator. Even so, >80% of the samples end up unusable, due to the extreme complexity of making samples. Sample preparation is therefore also incredibly costly, as imaging time on expensive Cryo-TEMs is wasted on trying to image unusable samples. In order to make cryo-ET fulfil its potential, the sample preparation has to become fast, cheap and reliable. DELMIC has completely reimagined the cryo-ET workflow, with the ultimate vision of completely automating sample preparation. Central to this workflow is the cryo-SECOM, which integrates a correlated cryo light microscope with a FIB/SEM system. Additionally, a unified carrier simplifies the placing and carrying samples around and the sample handling and loading/unloading procedures are automatized. We will tie all workstations together, basically creating a ‘cryo-ET sample prep robot’. This fully integrated workflow approach reduces the switching between many workstations, gives higher yield, and offers unprecedented precision in targeting the area of interest. By simplifying the workflow and reducing the preparation time, the Cryo-SECOM Workflow will allow researchers to innovate faster, decreasing the sample preparation time by 87% and improving the yield by 8-fold. The cost per sample will be greatly reduced by 90%. The Cryo-SECOM Workflow will be key in unlocking the full potential cryo-ET, opening new horizons in structural biology research. ' '

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CRYO-SECOM WORKFLOW" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CRYO-SECOM WORKFLOW" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.3.;H2020-EU.2.3.;H2020-EU.2.1.)

DeltaQon (2019)

IOT and cloud computing for online medical analysis service platform

Read More  

LTS (2020)


Read More  

MindTrack (2019)

Analysis of eye vergence responses for the early detection and monitoring of cognitive and mental disorders

Read More