Opendata, web and dolomites

Cryo-SECOM Workflow SIGNED

Unlocking the potential of cryo-electron tomography by simplification of the sample preparation workflow

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Cryo-SECOM Workflow project word cloud

Explore the words cloud of the Cryo-SECOM Workflow project. It provides you a very rough idea of what is the project "Cryo-SECOM Workflow" about.

fib    prize    tomography    secom    em    innovate    operator    vision    horizons    handling    simplifying    ultimate    trying    electron    tems    imaging    area    90    precision    image    manual    sem    incredibly    microscope    nobel    central    simplifies    structure    unlocking    unusable    yield    cryo    integrates    fast    microscopy    unprecedented    basically    reimagined    cheap    completely    tie    cells    samples    light    decreasing    opening    faster    preparation    reducing    delmic    unified    protein    fold    22    robot    automating    offers    expensive    complexity    workstations    gives    additionally    full    unloading    wasted    fulfil    reduces    80    placing    2017    gt    carrier    bacteria    workflow    et    switching    87    quaternary    tremendously    tertiary    costly    prep    loading    time    resolve    performed    phd    hours    structural    automatized    interactions    extreme    biological    biology    bottleneck    chemistry    correlated   

Project "Cryo-SECOM Workflow" data sheet

The following table provides information about the project.

Coordinator
DELMIC BV 

Organization address
address: KANAALWEG 4
city: DELFT
postcode: 2628EB
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 3˙062˙500 €
 EC max contribution 2˙143˙750 € (70%)
 Programme 1. H2020-EU.3. (PRIORITY 'Societal challenges)
2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs)
3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
 Code Call H2020-SMEInst-2018-2020-2
 Funding Scheme SME-2
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DELMIC BV NL (DELFT) coordinator 2˙143˙750.00

Map

 Project objective

'The interest for cryo electron microscopy (cryo-EM) has risen tremendously since the Nobel Prize in Chemistry 2017 was given for Cryo-EM. The next step in Cryo EM, Cryo Electron Tomography (cryo-ET), makes it possible to resolve tertiary and quaternary protein structure interactions in relevant biological samples such as cells and bacteria. However, in the current cryo-ET workflow the sample preparation is the bottleneck. Today, sample preparation is a manual process of 4-8 hours, involves 22 steps and is performed by a PhD level operator. Even so, >80% of the samples end up unusable, due to the extreme complexity of making samples. Sample preparation is therefore also incredibly costly, as imaging time on expensive Cryo-TEMs is wasted on trying to image unusable samples. In order to make cryo-ET fulfil its potential, the sample preparation has to become fast, cheap and reliable. DELMIC has completely reimagined the cryo-ET workflow, with the ultimate vision of completely automating sample preparation. Central to this workflow is the cryo-SECOM, which integrates a correlated cryo light microscope with a FIB/SEM system. Additionally, a unified carrier simplifies the placing and carrying samples around and the sample handling and loading/unloading procedures are automatized. We will tie all workstations together, basically creating a ‘cryo-ET sample prep robot’. This fully integrated workflow approach reduces the switching between many workstations, gives higher yield, and offers unprecedented precision in targeting the area of interest. By simplifying the workflow and reducing the preparation time, the Cryo-SECOM Workflow will allow researchers to innovate faster, decreasing the sample preparation time by 87% and improving the yield by 8-fold. The cost per sample will be greatly reduced by 90%. The Cryo-SECOM Workflow will be key in unlocking the full potential cryo-ET, opening new horizons in structural biology research. ' '

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CRYO-SECOM WORKFLOW" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CRYO-SECOM WORKFLOW" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.3.;H2020-EU.2.3.;H2020-EU.2.1.)

MCBD (2019)

MCBD (MULTI-CORE BIOPSY DEVICE) INNOVATIVE BIOPSY TECHNOLOGY FOR THE NEW ERA OF TARGETED MEDICINE

Read More  

ALICE (2019)

Armored Liftable anti-Intrusion Control Equipment

Read More  

Plasmanorg (2019)

Environmental-friendly organic chemical synthesis in plasma reactor

Read More