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BioSilica SIGNED

Materials synthesis in vivo – intracellular formation of nanostructured silica by microalgae

Total Cost €

0

EC-Contrib. €

0

Partnership

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 BioSilica project word cloud

Explore the words cloud of the BioSilica project. It provides you a very rough idea of what is the project "BioSilica" about.

catalysis    mineralization    porous    prominent    living    man    spectroscopy    feasible    reaching    principles    nano    environmentally    stabilization    diatoms    environmental    made    environment    photonics    nanotechnology    regulated    transient    nanoscale    functional    tough    inspire    intracellular    material    concentration    elusive    form    condensation    nanometer    si    inside    chemical    inaccessibility    pharmaceuticals    synthetic    mechanism    genetically    undergoing    obstacle    outcomes    biomineralization    biological    ray    area    array    organisms    combination    place    diatom    surface    meso    elucidating    phases    situ    imaging    nevertheless    genetic    silicification    engineer    tools    intricate    microalgae    marine    suite    hierarchically    persistent    strategies    electron    revolutionized    biocompatible    cell    cellular    image    microscopy    elucidate    magnificent    silica    cells    surpass    achievements    hierarchical    investigations    structural    designed    wall    cheap    resolution    analyze    data    takes    custom    patterned    materials   

Project "BioSilica" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 1˙500˙000.00

Map

 Project objective

Organisms evolved the ability to form a magnificent array of functional materials, which surpass any man-made product. A prominent example is diatoms, marine microalgae that form an intricate cell-wall made of meso-porous silica. Diatom silica is a tough, hierarchically built, and biocompatible material that is environmentally friendly and cheap, making it an exciting target for nanotechnology. Nevertheless, the principles of this regulated formation mechanism remain elusive. A persistent obstacle for elucidating biomineralization processes is the inaccessibility of the cellular environment for structural and chemical investigations. Recently, far-reaching developments in electron microscopy have revolutionized our abilities to investigate chemical processes inside living organisms. It is now becoming feasible to image and analyze, with nanometer-scale resolution, an intracellular mineralization process. This proposal aims to elucidate the intracellular mechanism of silica formation by diatoms. We will study cells undergoing the silicification process in situ, using a suite of state-of-the-art electron and X-ray imaging and spectroscopy tools. The combination of structural and chemical data will enable us to elucidate: 1) The concentration and stabilization mechanism of transient Si phases in the cell. 2) The nanoscale environment in which silica condensation takes place. 3) Genetic and environmental strategies to engineer the silicification process for designed outcomes. Diatom silica is a promising material for applications such as photonics, pharmaceuticals, and catalysis, which require hierarchical, high-surface area, nano-materials. The achievements of this project will inspire synthetic methodologies to produce and design nano-patterned silica, and genetically-engineer the biological silicification process to produce custom-made materials.

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The information about "BIOSILICA" are provided by the European Opendata Portal: CORDIS opendata.

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