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BioSilica SIGNED

Materials synthesis in vivo – intracellular formation of nanostructured silica by microalgae

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BioSilica project word cloud

Explore the words cloud of the BioSilica project. It provides you a very rough idea of what is the project "BioSilica" about.

structural    condensation    inaccessibility    form    tools    image    revolutionized    meso    biocompatible    data    microscopy    intracellular    spectroscopy    resolution    place    nanoscale    inside    nano    takes    area    investigations    genetically    cells    reaching    nanometer    hierarchical    diatoms    silicification    transient    strategies    custom    persistent    ray    man    designed    situ    chemical    biological    outcomes    genetic    photonics    materials    engineer    magnificent    inspire    analyze    intricate    environment    environmentally    hierarchically    prominent    surpass    material    biomineralization    elucidating    regulated    achievements    array    suite    undergoing    marine    nevertheless    obstacle    silica    porous    cellular    environmental    combination    functional    stabilization    elucidate    tough    mechanism    electron    concentration    diatom    wall    living    patterned    made    mineralization    si    elusive    synthetic    microalgae    principles    catalysis    pharmaceuticals    organisms    imaging    surface    cell    nanotechnology    cheap    phases    feasible   

Project "BioSilica" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 1˙500˙000.00

Map

 Project objective

Organisms evolved the ability to form a magnificent array of functional materials, which surpass any man-made product. A prominent example is diatoms, marine microalgae that form an intricate cell-wall made of meso-porous silica. Diatom silica is a tough, hierarchically built, and biocompatible material that is environmentally friendly and cheap, making it an exciting target for nanotechnology. Nevertheless, the principles of this regulated formation mechanism remain elusive. A persistent obstacle for elucidating biomineralization processes is the inaccessibility of the cellular environment for structural and chemical investigations. Recently, far-reaching developments in electron microscopy have revolutionized our abilities to investigate chemical processes inside living organisms. It is now becoming feasible to image and analyze, with nanometer-scale resolution, an intracellular mineralization process. This proposal aims to elucidate the intracellular mechanism of silica formation by diatoms. We will study cells undergoing the silicification process in situ, using a suite of state-of-the-art electron and X-ray imaging and spectroscopy tools. The combination of structural and chemical data will enable us to elucidate: 1) The concentration and stabilization mechanism of transient Si phases in the cell. 2) The nanoscale environment in which silica condensation takes place. 3) Genetic and environmental strategies to engineer the silicification process for designed outcomes. Diatom silica is a promising material for applications such as photonics, pharmaceuticals, and catalysis, which require hierarchical, high-surface area, nano-materials. The achievements of this project will inspire synthetic methodologies to produce and design nano-patterned silica, and genetically-engineer the biological silicification process to produce custom-made materials.

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The information about "BIOSILICA" are provided by the European Opendata Portal: CORDIS opendata.

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