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BioSilica SIGNED

Materials synthesis in vivo – intracellular formation of nanostructured silica by microalgae

Total Cost €

0

EC-Contrib. €

0

Partnership

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 BioSilica project word cloud

Explore the words cloud of the BioSilica project. It provides you a very rough idea of what is the project "BioSilica" about.

patterned    area    surface    silica    transient    diatom    resolution    tools    data    investigations    takes    cheap    intricate    cells    principles    achievements    structural    material    biocompatible    engineer    inspire    prominent    genetic    catalysis    hierarchical    materials    concentration    ray    condensation    tough    mineralization    elusive    genetically    photonics    inside    marine    magnificent    image    stabilization    nanoscale    regulated    nanotechnology    microscopy    spectroscopy    si    pharmaceuticals    imaging    nevertheless    custom    surpass    obstacle    cell    elucidating    microalgae    designed    hierarchically    phases    functional    array    environmentally    inaccessibility    nano    intracellular    undergoing    chemical    analyze    outcomes    meso    combination    nanometer    diatoms    porous    cellular    biological    situ    silicification    feasible    environment    made    revolutionized    place    suite    elucidate    living    man    biomineralization    form    electron    strategies    reaching    environmental    mechanism    wall    organisms    synthetic    persistent   

Project "BioSilica" data sheet

The following table provides information about the project.

Coordinator		 WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country Israel [IL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 1˙500˙000.00

Map

 Project objective

Organisms evolved the ability to form a magnificent array of functional materials, which surpass any man-made product. A prominent example is diatoms, marine microalgae that form an intricate cell-wall made of meso-porous silica. Diatom silica is a tough, hierarchically built, and biocompatible material that is environmentally friendly and cheap, making it an exciting target for nanotechnology. Nevertheless, the principles of this regulated formation mechanism remain elusive. A persistent obstacle for elucidating biomineralization processes is the inaccessibility of the cellular environment for structural and chemical investigations. Recently, far-reaching developments in electron microscopy have revolutionized our abilities to investigate chemical processes inside living organisms. It is now becoming feasible to image and analyze, with nanometer-scale resolution, an intracellular mineralization process. This proposal aims to elucidate the intracellular mechanism of silica formation by diatoms. We will study cells undergoing the silicification process in situ, using a suite of state-of-the-art electron and X-ray imaging and spectroscopy tools. The combination of structural and chemical data will enable us to elucidate: 1) The concentration and stabilization mechanism of transient Si phases in the cell. 2) The nanoscale environment in which silica condensation takes place. 3) Genetic and environmental strategies to engineer the silicification process for designed outcomes. Diatom silica is a promising material for applications such as photonics, pharmaceuticals, and catalysis, which require hierarchical, high-surface area, nano-materials. The achievements of this project will inspire synthetic methodologies to produce and design nano-patterned silica, and genetically-engineer the biological silicification process to produce custom-made materials.

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The information about "BIOSILICA" are provided by the European Opendata Portal: CORDIS opendata.

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