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SUMiDENTITY SIGNED

Deconstructing the role of SUMO on chromatin in cell identity and tissue repair

Total Cost €

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EC-Contrib. €

0

Partnership

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 SUMiDENTITY project word cloud

Explore the words cloud of the SUMiDENTITY project. It provides you a very rough idea of what is the project "SUMiDENTITY" about.

paradigm    tissue    configurations    plays    function    principally    transcriptional    paradigmatic    dynamic    accompanies    dynamics    rapid    critical    opening    identities    avenues    deconjugating    determined    roles    biology    specifications    chromosomal    repair    pluripotent    maintaining    actively    cancer    somatic    chromatin    mechanisms    identity    effort    safeguard    desumoylation    medicine    barrier    mark    cellular    transcription    molecular    cell    questions    fate    injury    transition    vision    central    deposits    totipotent    distinctive    escs    determinants    mechanism    sumo    acts    reciprocally    disease    bound    enforces    uncovered    druggable    gene    reprogramming    explore    underlying    experimental    regulatory    toward    regulated    complementary    conjugating    locus    complexes    regulating    stabilizer    provides    transitions    treatment    pathophysiological    maintenance    notably    substrates    resisting    muscle    fibroblasts    existence    interplay    balance    subverted    pluripotency    types    specify    equilibrium    loci    regulators    functions    corrupted    poorly    sumoylation    regenerative    integrate   

Project "SUMiDENTITY" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙499˙995 €
 EC max contribution 2˙499˙995 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 2˙499˙995.00

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 Project objective

The maintenance of cell identity and how it is subverted in disease are central questions in biology and medicine. The interplay between transcription factor and chromatin configurations plays a key role in maintaining cellular identity, yet how this interplay is regulated is poorly understood. Notably, the existence of possible general mechanisms underlying different cell-state specifications remains to be determined. We have recently uncovered evidence that sumoylation, which deposits a chromatin-associated mark (SUMO) that principally targets transcriptional regulators, acts as a general barrier to cell-fate transitions and enforces two distinctive chromatin types to safeguard somatic and pluripotent cell identities. The central paradigm for the proposed work is that SUMO functions as a general stabilizer of critical chromatin-bound determinants of cell identity and that the equilibrium between conjugating/deconjugating activities provides a general regulatory mechanism for their dynamic targeting to key chromosomal loci, thus actively contributing to cell-fate change. Focusing on reprogramming to pluripotency and transition to totipotent-like states, we propose to: 1) identify relevant locus-specific SUMO substrates/complexes in fibroblasts and ESCs, 2) define the role of SUMO in regulating their function and dynamics and, reciprocally, 3) explore the sumoylation/desumoylation balance that accompanies cell-fate change. A complementary effort seeks 4) to exploit these experimental approaches to study a paradigmatic pathophysiological process involving rapid cell-fate transitions: tissue repair following muscle injury. With a vision toward targeting this druggable pathway for regenerative medicine and cancer treatment, we expect these studies to integrate the gene regulatory roles of SUMO in resisting cell-fate change, thus opening up new avenues to the molecular mechanisms that specify cell identity during development and to how they are corrupted in disease.

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