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PROT-RESIST SIGNED

Toward the Commercialization of a Proteolytically Resistant APPI Variant for Inhibiting Metastasis in Prostate and Pancreatic Cancer

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PROT-RESIST project word cloud

Explore the words cloud of the PROT-RESIST project. It provides you a very rough idea of what is the project "PROT-RESIST" about.

prostate    leaders    antimetastatic    metastasis    ip    scaffold    amyloid    therapy    parallel    input    optimization    nevertheless    primary    domain    perform    contribution    agents    stage    exhibits    translated    protease    cancer    adjuvant    invasion    beta    clearance    opinion    consequently    carry    engineered    planning    designated    prototype    commercialization    therapeutic    inhibitor    translation    poc    precursor    site    final    specificity    enhanced    confirm    binding    models    promotes    market    cancers    preclinical    intervention    pancreatic    deaths    tumor    care    tumors    protocols    metastatic    stg    medical    resistance    clinical    involvement    generate    directed    therapies    evolution    picomolar    cell    human    treatments    affinity    clinicians    body    feedback    protein    kunitz    windows    mesotrypsin    proteolytic    indications    urgent    soc    anti    ongoing    attractive    feasible    experts    direct    erc    progression    appi    distal    standard    serine    3m    potency    neoadjuvant    decreasing   

Project "PROT-RESIST" data sheet

The following table provides information about the project.

Coordinator
BEN-GURION UNIVERSITY OF THE NEGEV 

Organization address
address: .
city: BEER SHEVA
postcode: 84105
website: www.bgu.ac.il

contact info
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name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Israel [IL]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BEN-GURION UNIVERSITY OF THE NEGEV IL (BEER SHEVA) coordinator 150˙000.00

Map

 Project objective

Distal site tumor metastasis is the leading cause of prostate- and pancreatic-cancer-related deaths; nevertheless, standard-of-care (SoC) treatments and other targeted therapies under development are based on their activity against the primary tumors rather than on their anti-metastatic activity. There is consequently an urgent medical need for new agents targeting the metastatic process. In prostate and pancreatic cancer models, the serine protease mesotrypsin promotes tumor invasion and metastasis, making it an attractive target for therapeutic intervention. In our ERC StG project, we used directed evolution to generate a novel prototype mesotrypsin inhibitor, designated APPI-3M, which is based on the human amyloid β-protein precursor Kunitz protease inhibitor domain (APPI) scaffold. This inhibitor has picomolar affinity, enhanced binding specificity and improved proteolytic resistance to mesotrypsin and exhibits high potency in cell-based and preclinical models of prostate cancer invasion and metastasis. In this PoC proposal, we propose to perform final lead optimization (particularly decreasing body clearance) of APPI-3M towards its commercialization for clinical translation as an antimetastatic therapeutic adjuvant, with the direct involvement in the planning stage of clinicians and other key opinion leaders in the field. The feedback of these experts is expected to confirm the need to address the problem of metastatic progression and to identify potential indications and therapeutic windows for the use of APPI-3M as a neoadjuvant in prostate and pancreatic cancers. This input will be translated into feasible preclinical studies to demonstrate the contribution of APPI-3M therapy to currently ongoing SoC protocols for prostate and pancreatic cancers. In parallel, we will carry out the in-depth market and IP analyses needed for the commercialization of the engineered protein for therapeutic applications.

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The information about "PROT-RESIST" are provided by the European Opendata Portal: CORDIS opendata.

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