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BREAK SIGNED

Blue light remote analgesia with K+ channels

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 BREAK project word cloud

Explore the words cloud of the BREAK project. It provides you a very rough idea of what is the project "BREAK" about.

lamp    chronic    cp    academic    painful    synergy    interpret    illness    invasive    genes    adoption    plan    optogenetic    antidepressants    opioids    progress    cm    stakeholder    designed    version    treat    gt    12    treatment    spectrum    genetically    reporting    neuron    proteins    nervous    peripheral    demonstrated    global    experiments    minutes    commercial    worse    difficult    cells    disorder    abnormal    lower    situation    hard    relief    causing    population    central    blink2    hours    fruitful    silencing    solution    origin    rats    treatments    constitute    damage    vivo    first    optical    trauma    explore    patients    injected    leads    despite    restraining    medical    skin    tool    weeks    initiated    originally    addiction    partial    brain    exact    nausea    nonspecific    light       drugs    hospitals    pain    mostly    prolonged    kept    device    entities    invasiveness    diagnose    implant    neuropathic    characterised    thirds    centers    stimuli    protein    drug    network    investor    extremely    class    area    break    np    adults    actually    blue    companies    20    inhibitory    pharma    normally    leveraging    distance    engineered    virus   

Project "BREAK" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI MILANO 

Organization address
address: Via Festa Del Perdono 7
city: MILANO
postcode: 20122
website: www.unimi.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) coordinator 150˙000.00

Map

 Project objective

Chronic pain (CP) is a medical condition affecting around 20% of adults in Europe, characterised by an abnormal duration of pain (> 12 weeks) originally initiated by a trauma or illness. Despite significant progress, CP remains extremely hard to treat, with only one-third to two-thirds of patients reporting adequate some pain relief. This situation is even worse for neuropathic pain (NP), a specific class of CP affecting 8% of global population and whose origin mostly depend on peripheral or central nervous damage or disorder, which leads the brain to interpret as pain normally non painful stimuli. NP is difficult to treat due to the large number of entities involved (cells, genes and proteins working in synergy), which makes it hard to rapidly diagnose the exact cause of pain. Drugs targeting the central nervous system (e.g. antidepressants and opioids) provide only partial pain relief and are nonspecific, also causing side effects like addiction, and nausea, thus restraining their adoption for prolonged treatments. BREAK is the first non-invasive inhibitory optogenetic tool specifically designed for NP treatment, with potential application to the whole spectrum of CP. BREAK is composed of a drug and an optical device. The protein BLINK2 is injected in the painful area using a genetically engineered virus, and respond to a specific blue light by silencing the addressed neuron. The lamp can be kept at some distance (cm) from the skin and no implant is required. Just some minutes of treatment results in hours of pain relief, making the invasiveness of BREAK far lower than actually existing solution. A first version of BREAK has already demonstrated in in-vivo experiments on rats. During this project we plan to further develop the treatment and explore its commercial potential. In particular, leveraging from the experience of different partners, we will constitute a fruitful stakeholder network, including Academic centers, hospitals, pharma companies and investor

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The information about "BREAK" are provided by the European Opendata Portal: CORDIS opendata.

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