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BREAK SIGNED

Blue light remote analgesia with K+ channels

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BREAK project word cloud

Explore the words cloud of the BREAK project. It provides you a very rough idea of what is the project "BREAK" about.

pain    treatment    interpret    engineered    constitute    skin    mostly    implant    np    thirds    illness    drugs    damage    nausea    originally    first    protein    blue    companies    abnormal    brain    8    weeks    investor    peripheral    situation    addiction    12    progress    treatments    leads    leveraging    fruitful    minutes    antidepressants    class    optical    commercial    genes    global    academic    painful    restraining    adults    cp    explore    break    difficult    partial    vivo    worse    pharma    cm    origin    trauma    despite    designed    tool    prolonged    blink2    centers    chronic    invasiveness    demonstrated    experiments    normally    treat    patients    hard    disorder    synergy    network    kept    neuron    exact    nervous    medical    actually    genetically    optogenetic    hospitals    reporting    gt    rats    causing    solution    spectrum    injected    stimuli    20    device    nonspecific    invasive    plan    relief    adoption    neuropathic    stakeholder    characterised    hours    entities    virus    silencing    cells    light    drug    diagnose    version    lower    area    proteins    opioids    lamp    distance    initiated    extremely    population    central    inhibitory   

Project "BREAK" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITA DEGLI STUDI DI MILANO 

Organization address
address: Via Festa Del Perdono 7
city: MILANO
postcode: 20122
website: www.unimi.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Italy [IT]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) coordinator 150˙000.00

Map

 Project objective

Chronic pain (CP) is a medical condition affecting around 20% of adults in Europe, characterised by an abnormal duration of pain (> 12 weeks) originally initiated by a trauma or illness. Despite significant progress, CP remains extremely hard to treat, with only one-third to two-thirds of patients reporting adequate some pain relief. This situation is even worse for neuropathic pain (NP), a specific class of CP affecting 8% of global population and whose origin mostly depend on peripheral or central nervous damage or disorder, which leads the brain to interpret as pain normally non painful stimuli. NP is difficult to treat due to the large number of entities involved (cells, genes and proteins working in synergy), which makes it hard to rapidly diagnose the exact cause of pain. Drugs targeting the central nervous system (e.g. antidepressants and opioids) provide only partial pain relief and are nonspecific, also causing side effects like addiction, and nausea, thus restraining their adoption for prolonged treatments. BREAK is the first non-invasive inhibitory optogenetic tool specifically designed for NP treatment, with potential application to the whole spectrum of CP. BREAK is composed of a drug and an optical device. The protein BLINK2 is injected in the painful area using a genetically engineered virus, and respond to a specific blue light by silencing the addressed neuron. The lamp can be kept at some distance (cm) from the skin and no implant is required. Just some minutes of treatment results in hours of pain relief, making the invasiveness of BREAK far lower than actually existing solution. A first version of BREAK has already demonstrated in in-vivo experiments on rats. During this project we plan to further develop the treatment and explore its commercial potential. In particular, leveraging from the experience of different partners, we will constitute a fruitful stakeholder network, including Academic centers, hospitals, pharma companies and investor

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The information about "BREAK" are provided by the European Opendata Portal: CORDIS opendata.

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