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REMEDIA SIGNED

Impact of exposome on the course of lung diseases

Total Cost €

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EC-Contrib. €

0

Partnership

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 REMEDIA project word cloud

Explore the words cloud of the REMEDIA project. It provides you a very rough idea of what is the project "REMEDIA" about.

outside    predict    versatile    models    mortality    exposome    play    causal    diseases    parallel    obstructive    modifiable    database    origin    pan    environmental    unknown    recommendations    unified    extend    mainly    sensor    action    2018    cohorts    external    deciphering    reducing    device    effectiveness    econometric    risk    roots    cystic    simulate    supervised    picture    toolbox    criteria    identification    health    debilitating    phenotype    fibrosis    global    cf    data    network    registries    additional    pulmonary    flexible    prevention    constitute    population    supplemented    gathering    tool    communicable    bhc    chamber    sc1    biomarker    prevents    contribution    life    strategies    combining    efficacy    clear    copd    good    remedia    guidelines    learning    human    exposomes    individual    simulation    performance    atmospheric    variability    opposite    therapeutic    components    inference    breakthrough    share    machine    morbidity    risks    create    model    toolkits    disease    2020    chronic    phenotypic    curable    preventive   

Project "REMEDIA" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 11˙134˙616 €
 EC max contribution 11˙134˙616 € (100%)
 Programme 1. H2020-EU.3.1.2. (Preventing disease)
 Code Call H2020-SC1-2019-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 2˙332˙877.00
2    UNIVERSITE DE PARIS FR (PARIS) participant 1˙672˙881.00
3    FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. DE (MUNCHEN) participant 1˙611˙674.00
4    CAMBRIDGE EPIGENETIX LIMITED UK (SAFFRON WALDEN) participant 1˙037˙694.00
5    DATA MINING INTERNATIONAL SA CH (GENEVE) participant 777˙500.00
6    LIPOTYPE DE (DRESDEN) participant 731˙250.00
7    CENTRE HOSPITALIER INTERCOMMUNAL DE CRETEIL FR (CRETEIL) participant 628˙315.00
8    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) participant 625˙750.00
9    IDRYMA TECHNOLOGIAS KAI EREVNAS EL (IRAKLEIO) participant 462˙500.00
10    INSERM TRANSFERT SA FR (PARIS) participant 442˙500.00
11    UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET NO (TROMSO) participant 345˙617.00
12    KRAEFTENS BEKAEMPELSE DK (KOEBENHAVN) participant 258˙556.00
13    LAURENT NIDDAM EUROPAI KOZOSSEGI JOGASZ IRODA HU (BUDAPEST) participant 207˙500.00
14    UNIVERSITE PARIS DIDEROT - PARIS 7 FR (PARIS) participant 0.00

Map

 Project objective

Chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) are two very debilitating non-communicable diseases that are of particular interest to consider in parallel in a human exposome study. Their roots are opposite: COPD is currently considered to be mainly related to the external exposome, while factors outside of the exposome play a major role in CF. However, COPD and CF share common characteristics such as high phenotypic variability of unknown origin, which prevents good therapeutic efficacy. It is therefore clear that the overall picture must be supplemented by taking into account additional components of the exposome than those currently considered in COPD and CF. Thus, the overall objective of the REMEDIA project is to extend the understanding of the contribution of the exposome, taken as a complex set of different components, to COPD and CF diseases. We will exploit data from existing cohorts and population registries in order to create a unified global database gathering phenotype and exposome information; we will develop a flexible individual sensor device combining environmental and biomarker toolkits; and use a versatile atmospheric simulation chamber to simulate the health effects of complex exposomes. We will use machine learning supervised analyses and causal inference models to identify relevant risk factors; and econometric and cost-effectiveness models to assess the costs, performance and cost-effectiveness of a selection of prevention strategies. The results will be used to develop guidelines to better predict disease risks and constitute the elements of the REMEDIA toolbox (global unified database, sensor device, versatile atmospheric simulation chamber, machine learning supervised analyses, causal inference model, Pan-European multi-criteria risk assessment tool, econometric models, cost-effectiveness models, new guidelines and recommendations). Deciphering the impact of environmental components throughout life on the phenotypic variability of COPD and CF could represent a major breakthrough in reducing morbidity and mortality associated with these two non-curable diseases and would lead to the identification of modifiable risk factors on which preventive action could be implemented. REMEDIA will be part of the European Human Exposome Network established between the 9 projects funded within the Human Exposome programme call H2020-SC1-BHC-2018-2020.

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The information about "REMEDIA" are provided by the European Opendata Portal: CORDIS opendata.

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