Opendata, web and dolomites

SIROCCO SIGNED

Remote control of cellular signalling triggered by magnetic switching

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SIROCCO project word cloud

Explore the words cloud of the SIROCCO project. It provides you a very rough idea of what is the project "SIROCCO" about.

powerful    burgeoning    treatment    transduction    models    fact    tissue    tested    adhesion    fragments    activation    mechanical    cross    successful    proteins    actuation    attached    stimuli    progression    modified    mnps    magnetic    signalling    clear    temporal    vitro    cells    functionalized    tool    hot    instance    tuned    cell    capitalizing    nanoparticles    engineering    lack    remote    membrane    stem    recognize    spatiotemporal    implication    switchers    cellular    understand    rests    functions    fate    modulate    disciplinary    once    healing    magnetomechanical    it    light    selectively    homeostasis    deep    signals    cadherins    wound    resolution    cutaneous    validated    mechanotransduction    constitutes    diseases    techniques    fundamental    external    tumour    activated    nanoswitchers    convert    situ    3d    possibility    intracellular    skin    helping    sirocco    scientific    living    genetically    sheds    regeneration    invasive    oriented    extremely    biochemical    2d    manner    precision    surface    receptors    turn   

Project "SIROCCO" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙798˙454 €
 EC max contribution 1˙798˙454 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-05-01   to  2025-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 1˙798˙454.00

Map

 Project objective

It is becoming increasingly clear that successful tissue engineering rests on capitalizing on more comprehensive understanding of mechanotransduction and its implication in skin homeostasis. In fact, the study of mechanotransduction is now a burgeoning research field, helping us to understand how cells respond to mechanical stimuli and convert them into biochemical signals, which in turn sheds light on the remote control of intracellular functions and the treatment of diseases. However, external activation of cellular signalling constitutes an important challenge due to the lack of non-invasive techniques that can be tuned in a spatiotemporal manner at a deep-tissue level. SIROCCO aims to control different pathways related with cutaneous mechanotransduction by using magnetic switchers in order to enhance wound healing. Magnetic nanoparticles functionalized with oriented fragments of proteins will selectively recognize cell surface adhesion receptors (cadherins) present on the membrane of living cells. Once attached to the cellular surface, the MNPs will be activated using external magnetic fields in order to control key intracellular pathways. This ambitious goal will be validated using genetically modified 2D and 3D in vitro models, and the possibility to enhance wound healing and to modulate stem cell fate will be tested. High precision remote control of cellular functions with temporal resolution is an extremely hot topic in tissue engineering. SIROCCO will go well beyond current state-of-the-art for non-invasive actuation of cellular functions in situ and will provide a powerful magnetomechanical transduction tool for mechanotransduction and tissue regeneration. The fundamental scientific advances proposed by SIROCCO are cross-disciplinary since these magnetic nanoswitchers may also find widespread applications in other processes where these pathways are involved, for instance in tumour progression.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SIROCCO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SIROCCO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

PROGRESS (2019)

The Enemy of the Good: Towards a Theory of Moral Progress

Read More  

FICOMOL (2019)

Field Control of Cold Molecular Collisions

Read More  

HOLI (2019)

Deep Learning for Holistic Inference

Read More