Opendata, web and dolomites

SIROCCO SIGNED

Remote control of cellular signalling triggered by magnetic switching

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SIROCCO project word cloud

Explore the words cloud of the SIROCCO project. It provides you a very rough idea of what is the project "SIROCCO" about.

tuned    cross    progression    lack    magnetic    constitutes    functionalized    cellular    activated    stem    sheds    engineering    modified    mechanotransduction    successful    implication    signals    once    functions    cutaneous    cells    diseases    fundamental    modulate    helping    actuation    signalling    deep    adhesion    temporal    spatiotemporal    biochemical    rests    3d    tool    it    scientific    2d    fate    recognize    sirocco    fact    understand    magnetomechanical    manner    living    disciplinary    vitro    models    possibility    light    tested    mnps    turn    instance    surface    oriented    selectively    wound    external    nanoswitchers    treatment    tissue    resolution    extremely    proteins    skin    convert    regeneration    nanoparticles    clear    switchers    techniques    activation    attached    healing    genetically    intracellular    situ    hot    precision    cadherins    cell    remote    receptors    tumour    fragments    capitalizing    stimuli    membrane    invasive    burgeoning    transduction    validated    homeostasis    mechanical    powerful   

Project "SIROCCO" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙798˙454 €
 EC max contribution 1˙798˙454 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-05-01   to  2025-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 1˙798˙454.00

Map

 Project objective

It is becoming increasingly clear that successful tissue engineering rests on capitalizing on more comprehensive understanding of mechanotransduction and its implication in skin homeostasis. In fact, the study of mechanotransduction is now a burgeoning research field, helping us to understand how cells respond to mechanical stimuli and convert them into biochemical signals, which in turn sheds light on the remote control of intracellular functions and the treatment of diseases. However, external activation of cellular signalling constitutes an important challenge due to the lack of non-invasive techniques that can be tuned in a spatiotemporal manner at a deep-tissue level. SIROCCO aims to control different pathways related with cutaneous mechanotransduction by using magnetic switchers in order to enhance wound healing. Magnetic nanoparticles functionalized with oriented fragments of proteins will selectively recognize cell surface adhesion receptors (cadherins) present on the membrane of living cells. Once attached to the cellular surface, the MNPs will be activated using external magnetic fields in order to control key intracellular pathways. This ambitious goal will be validated using genetically modified 2D and 3D in vitro models, and the possibility to enhance wound healing and to modulate stem cell fate will be tested. High precision remote control of cellular functions with temporal resolution is an extremely hot topic in tissue engineering. SIROCCO will go well beyond current state-of-the-art for non-invasive actuation of cellular functions in situ and will provide a powerful magnetomechanical transduction tool for mechanotransduction and tissue regeneration. The fundamental scientific advances proposed by SIROCCO are cross-disciplinary since these magnetic nanoswitchers may also find widespread applications in other processes where these pathways are involved, for instance in tumour progression.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SIROCCO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SIROCCO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

PROPERTY[IN]JUSTICE (2020)

Land, Property and Spatial Justice in International Law

Read More  

EpigeneticScars (2020)

Understanding DSB repair from pathway choice to long term effects and their consequences.

Read More  

sociOlfa (2020)

Learning from social scents: from territory to identity

Read More