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EDUC8 SIGNED

Early Stage Researchers EDUCational Program on Factor VIII Immunogenicity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EDUC8 project word cloud

Explore the words cloud of the EDUC8 project. It provides you a very rough idea of what is the project "EDUC8" about.

positive    resource    accumulated    imagination    therapeutic    discoveries    practical    technologies    human    immunology    conception    multidisciplinary    science    michel    translational    patient    decreasing    esrs    educ8    200    center    patients    proteins    pragmatism    coined    deep    multicultural    philosopher    basic    onset    considerations    viii    training    ethical    theoretic    immunogenicity    montaigne    societal    owing    exogenous    complication    creation    exposure    anti    drug    enrolled    fviii    omic    antibodies    generation    education    public    burden    true    replacement    strategic    mind    de    biotherapeutics    treatment    immersion    neutralizing    pro    private    academic    hemostasis    form    core    inhibitor    exceeds    haemophilia    inhibitors    entrepreneurship    coagulant    anticipate    french    clinical    realistic    therapy    tomorrow    scientific    sectors    individual    enormous    phd    financial    ambition    scientists    startups    tribute    educational   

Project "EDUC8" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙100˙708 €
 EC max contribution 2˙100˙708 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2019
 Funding Scheme MSCA-ITN-ETN
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2024-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 274˙802.00
2    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES FR (PARIS 15) participant 274˙802.00
3    DC4U NL (BREUKELEN) participant 265˙619.00
4    Stichting Sanquin Bloedvoorziening NL (Amsterdam) participant 265˙619.00
5    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) participant 261˙499.00
6    JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE (FRANKFURT AM MAIN) participant 252˙788.00
7    TOPAS THERAPEUTICS GMBH DE (HAMBURG) participant 252˙788.00
8    UNIVERSITAETSKLINIKUM BONN DE (BONN) participant 252˙788.00

Map

 Project objective

The development of anti-drug antibodies is the major complication of treatment with biotherapeutics. This is particularly true of patients with haemophilia A (HA) who develop neutralizing antibodies to therapeutic factor VIII (FVIII) following replacement therapy with exogenous pro-coagulant FVIII. The onset of neutralizing antibodies to FVIII, referred to as FVIII inhibitors, represents a major societal concern owing to the enormous cost associated to the clinical management of inhibitor-positive patients, that exceeds 200,000€/patient/year. The EDUC8 program is a multidisciplinary training program with exposure of the enrolled ESRs to a core common educational package and development of individual PhD research projects dedicated to decreasing the societal burden associated with the development of anti-FVIII antibodies in Europe. The core educational program includes exposure to basic science in the fields of immunology and hemostasis, to the most advanced “omic” technologies in order to anticipate tomorrow’s scientific discoveries, and to the importance of ethical considerations and public awareness in today’s research. A key component of the training program is provided by immersion of the ESRs in a clinical center for HA, which will provide them with a unique experience and foster the conception of novel and realistic therapeutic approaches. The ESRs will exploit the accumulated theoretic and practical experience in an entrepreneurship training on key strategic, technical, financial and human resource issues required for the creation of startups. In a tribute to the concept of the fully developed mind coined by the French philosopher Michel de Montaigne on education, our ambition is to form a novel generation of scientists with deep scientific knowledge, multicultural exposure, imagination, pragmatism and understanding of both the academic and private sectors. This will foster translational research in European on the immunogenicity of therapeutic proteins.

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The information about "EDUC8" are provided by the European Opendata Portal: CORDIS opendata.

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