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EDUC8 SIGNED

Early Stage Researchers EDUCational Program on Factor VIII Immunogenicity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EDUC8 project word cloud

Explore the words cloud of the EDUC8 project. It provides you a very rough idea of what is the project "EDUC8" about.

burden    viii    immunology    startups    tomorrow    antibodies    fviii    public    replacement    financial    treatment    realistic    decreasing    anticipate    resource    pro    complication    educational    coined    french    strategic    positive    inhibitor    montaigne    translational    exceeds    esrs    de    form    clinical    mind    accumulated    inhibitors    enormous    phd    human    exogenous    tribute    scientists    owing    core    true    patients    center    considerations    drug    philosopher    private    omic    proteins    onset    educ8    scientific    societal    patient    hemostasis    academic    practical    conception    ethical    basic    science    deep    immersion    training    generation    immunogenicity    therapy    discoveries    technologies    education    michel    anti    pragmatism    haemophilia    biotherapeutics    theoretic    therapeutic    200    multidisciplinary    neutralizing    multicultural    individual    enrolled    coagulant    exposure    entrepreneurship    creation    ambition    imagination    sectors   

Project "EDUC8" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙100˙708 €
 EC max contribution 2˙100˙708 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2019
 Funding Scheme MSCA-ITN-ETN
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2024-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 274˙802.00
2    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES FR (PARIS 15) participant 274˙802.00
3    DC4U NL (BREUKELEN) participant 265˙619.00
4    Stichting Sanquin Bloedvoorziening NL (Amsterdam) participant 265˙619.00
5    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) participant 261˙499.00
6    JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE (FRANKFURT AM MAIN) participant 252˙788.00
7    TOPAS THERAPEUTICS GMBH DE (HAMBURG) participant 252˙788.00
8    UNIVERSITAETSKLINIKUM BONN DE (BONN) participant 252˙788.00

Map

 Project objective

The development of anti-drug antibodies is the major complication of treatment with biotherapeutics. This is particularly true of patients with haemophilia A (HA) who develop neutralizing antibodies to therapeutic factor VIII (FVIII) following replacement therapy with exogenous pro-coagulant FVIII. The onset of neutralizing antibodies to FVIII, referred to as FVIII inhibitors, represents a major societal concern owing to the enormous cost associated to the clinical management of inhibitor-positive patients, that exceeds 200,000€/patient/year. The EDUC8 program is a multidisciplinary training program with exposure of the enrolled ESRs to a core common educational package and development of individual PhD research projects dedicated to decreasing the societal burden associated with the development of anti-FVIII antibodies in Europe. The core educational program includes exposure to basic science in the fields of immunology and hemostasis, to the most advanced “omic” technologies in order to anticipate tomorrow’s scientific discoveries, and to the importance of ethical considerations and public awareness in today’s research. A key component of the training program is provided by immersion of the ESRs in a clinical center for HA, which will provide them with a unique experience and foster the conception of novel and realistic therapeutic approaches. The ESRs will exploit the accumulated theoretic and practical experience in an entrepreneurship training on key strategic, technical, financial and human resource issues required for the creation of startups. In a tribute to the concept of the fully developed mind coined by the French philosopher Michel de Montaigne on education, our ambition is to form a novel generation of scientists with deep scientific knowledge, multicultural exposure, imagination, pragmatism and understanding of both the academic and private sectors. This will foster translational research in European on the immunogenicity of therapeutic proteins.

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The information about "EDUC8" are provided by the European Opendata Portal: CORDIS opendata.

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