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EDUC8 SIGNED

Early Stage Researchers EDUCational Program on Factor VIII Immunogenicity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EDUC8 project word cloud

Explore the words cloud of the EDUC8 project. It provides you a very rough idea of what is the project "EDUC8" about.

sectors    deep    generation    realistic    burden    tribute    ambition    antibodies    inhibitors    omic    positive    proteins    pro    technologies    phd    philosopher    educ8    public    exceeds    accumulated    private    individual    onset    drug    core    inhibitor    therapeutic    basic    patient    hemostasis    immunogenicity    immersion    strategic    scientific    exposure    200    anti    form    human    enrolled    education    clinical    startups    entrepreneurship    owing    ethical    exogenous    mind    biotherapeutics    french    decreasing    theoretic    training    immunology    tomorrow    treatment    patients    educational    considerations    enormous    financial    montaigne    coined    de    scientists    societal    complication    haemophilia    replacement    coagulant    therapy    practical    michel    multidisciplinary    translational    viii    academic    discoveries    science    neutralizing    esrs    imagination    true    multicultural    resource    center    fviii    anticipate    creation    pragmatism    conception   

Project "EDUC8" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙100˙708 €
 EC max contribution 2˙100˙708 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2019
 Funding Scheme MSCA-ITN-ETN
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2024-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 274˙802.00
2    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES FR (PARIS 15) participant 274˙802.00
3    DC4U NL (BREUKELEN) participant 265˙619.00
4    Stichting Sanquin Bloedvoorziening NL (Amsterdam) participant 265˙619.00
5    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) participant 261˙499.00
6    JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE (FRANKFURT AM MAIN) participant 252˙788.00
7    TOPAS THERAPEUTICS GMBH DE (HAMBURG) participant 252˙788.00
8    UNIVERSITAETSKLINIKUM BONN DE (BONN) participant 252˙788.00

Map

 Project objective

The development of anti-drug antibodies is the major complication of treatment with biotherapeutics. This is particularly true of patients with haemophilia A (HA) who develop neutralizing antibodies to therapeutic factor VIII (FVIII) following replacement therapy with exogenous pro-coagulant FVIII. The onset of neutralizing antibodies to FVIII, referred to as FVIII inhibitors, represents a major societal concern owing to the enormous cost associated to the clinical management of inhibitor-positive patients, that exceeds 200,000€/patient/year. The EDUC8 program is a multidisciplinary training program with exposure of the enrolled ESRs to a core common educational package and development of individual PhD research projects dedicated to decreasing the societal burden associated with the development of anti-FVIII antibodies in Europe. The core educational program includes exposure to basic science in the fields of immunology and hemostasis, to the most advanced “omic” technologies in order to anticipate tomorrow’s scientific discoveries, and to the importance of ethical considerations and public awareness in today’s research. A key component of the training program is provided by immersion of the ESRs in a clinical center for HA, which will provide them with a unique experience and foster the conception of novel and realistic therapeutic approaches. The ESRs will exploit the accumulated theoretic and practical experience in an entrepreneurship training on key strategic, technical, financial and human resource issues required for the creation of startups. In a tribute to the concept of the fully developed mind coined by the French philosopher Michel de Montaigne on education, our ambition is to form a novel generation of scientists with deep scientific knowledge, multicultural exposure, imagination, pragmatism and understanding of both the academic and private sectors. This will foster translational research in European on the immunogenicity of therapeutic proteins.

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The information about "EDUC8" are provided by the European Opendata Portal: CORDIS opendata.

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