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EDUC8 SIGNED

Early Stage Researchers EDUCational Program on Factor VIII Immunogenicity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EDUC8 project word cloud

Explore the words cloud of the EDUC8 project. It provides you a very rough idea of what is the project "EDUC8" about.

training    owing    michel    accumulated    translational    immunogenicity    proteins    exposure    immunology    academic    patient    societal    biotherapeutics    phd    realistic    human    sectors    antibodies    exogenous    true    mind    basic    philosopher    drug    positive    inhibitor    200    ambition    fviii    pragmatism    inhibitors    scientific    therapy    coagulant    startups    decreasing    ethical    education    core    viii    therapeutic    tomorrow    treatment    anticipate    individual    financial    multidisciplinary    multicultural    theoretic    replacement    creation    strategic    haemophilia    patients    omic    deep    discoveries    considerations    science    montaigne    hemostasis    exceeds    educational    entrepreneurship    public    imagination    french    immersion    practical    neutralizing    scientists    enrolled    educ8    tribute    conception    technologies    onset    pro    de    form    resource    burden    enormous    center    complication    generation    clinical    private    esrs    anti    coined   

Project "EDUC8" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙100˙708 €
 EC max contribution 2˙100˙708 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2019
 Funding Scheme MSCA-ITN-ETN
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2024-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 274˙802.00
2    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES FR (PARIS 15) participant 274˙802.00
3    DC4U NL (BREUKELEN) participant 265˙619.00
4    Stichting Sanquin Bloedvoorziening NL (Amsterdam) participant 265˙619.00
5    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) participant 261˙499.00
6    JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE (FRANKFURT AM MAIN) participant 252˙788.00
7    TOPAS THERAPEUTICS GMBH DE (HAMBURG) participant 252˙788.00
8    UNIVERSITAETSKLINIKUM BONN DE (BONN) participant 252˙788.00

Map

 Project objective

The development of anti-drug antibodies is the major complication of treatment with biotherapeutics. This is particularly true of patients with haemophilia A (HA) who develop neutralizing antibodies to therapeutic factor VIII (FVIII) following replacement therapy with exogenous pro-coagulant FVIII. The onset of neutralizing antibodies to FVIII, referred to as FVIII inhibitors, represents a major societal concern owing to the enormous cost associated to the clinical management of inhibitor-positive patients, that exceeds 200,000€/patient/year. The EDUC8 program is a multidisciplinary training program with exposure of the enrolled ESRs to a core common educational package and development of individual PhD research projects dedicated to decreasing the societal burden associated with the development of anti-FVIII antibodies in Europe. The core educational program includes exposure to basic science in the fields of immunology and hemostasis, to the most advanced “omic” technologies in order to anticipate tomorrow’s scientific discoveries, and to the importance of ethical considerations and public awareness in today’s research. A key component of the training program is provided by immersion of the ESRs in a clinical center for HA, which will provide them with a unique experience and foster the conception of novel and realistic therapeutic approaches. The ESRs will exploit the accumulated theoretic and practical experience in an entrepreneurship training on key strategic, technical, financial and human resource issues required for the creation of startups. In a tribute to the concept of the fully developed mind coined by the French philosopher Michel de Montaigne on education, our ambition is to form a novel generation of scientists with deep scientific knowledge, multicultural exposure, imagination, pragmatism and understanding of both the academic and private sectors. This will foster translational research in European on the immunogenicity of therapeutic proteins.

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The information about "EDUC8" are provided by the European Opendata Portal: CORDIS opendata.

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