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INSPIRE SIGNED

INnovation in Safety Pharmacology for Integrated cardiovascular safety assessment to REduce adverse events and late stage drug attrition.

Total Cost €

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EC-Contrib. €

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Partnership

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 INSPIRE project word cloud

Explore the words cloud of the INSPIRE project. It provides you a very rough idea of what is the project "INSPIRE" about.

inspire    pharmacology    balanced    representing    scientific    cardiovascular    functional    vi    mechanisms    expertise    skills    wp2    laboratory    humanized    exploration    validated    clinical    providers    events    vitro    attrition    wp4    courses    create    multidisciplinary    collaborations    imaging    esrs    feedback    hence    preclinical    adapt    delivering    additionally    hardware    secondments    pharmacodynamic    spectroscopy    exploring    hands    wp3    off    understand    combination    teams    exposure    hospitals    companies    cv    unparalleled    transferable    equip    prevalent    candidates    cardio    limitation    network    drug    oncology    screening    toxicity    reduce    undesirable    software    adverse    academic    silico    pharmaceutical    constitutes    toxicities    detect    industry    mass    vision    animals    technological    haemodynamics    15    generation    onset    training    screens    assays    structural    vivo    new    uses    wp1    cardiomyocytes    intersectoral    regulators    changing    platform    solutions    ing    predictions    dynamic    local    fail    integration    thereby    scientists    sp    innovative    safety    unites    3rs    indicates    stage   

Project "INSPIRE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT ANTWERPEN 

Organization address
address: PRINSSTRAAT 13
city: ANTWERPEN
postcode: 2000
website: www.ua.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 4˙021˙968 €
 EC max contribution 4˙021˙968 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2019
 Funding Scheme MSCA-ITN-ETN
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT ANTWERPEN BE (ANTWERPEN) coordinator 768˙960.00
2    THE UNIVERSITY OF NOTTINGHAM UK (NOTTINGHAM) participant 606˙345.00
3    NOTOCORD SYSTEMS FR (LE PECQ) participant 549˙604.00
4    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) participant 531˙239.00
5    INSTITUT NATIONAL DE RECHERCHE ENINFORMATIQUE ET AUTOMATIQUE FR (LE CHESNAY CEDEX) participant 274˙802.00
6    NCARDIA BV NL (LEIDEN) participant 265˙619.00
7    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) participant 263˙500.00
8    UCB BIOPHARMA SRL BE (BRUXELLES) participant 256˙320.00
9    BOEHRINGER INGELHEIM PHARMA GMBH &CO KG DE (INGELHEIM) participant 252˙788.00
10    TSE SYSTEMS GMBH DE (BAD HOMBURG VOR DER HOHE) participant 252˙788.00

Map

 Project objective

New drug candidates often have off-target effects resulting in adverse events, thus representing a major limitation for drug R&D. Safety Pharmacology (SP) aims to detect, understand and reduce undesirable pharmacodynamic effects early-on. Especially, cardiovascular (CV) toxicity is problematic, as it is the most prevalent reason for failure during preclinical development. Moreover, CV toxicity remains a key reason for drug attrition during clinical development and beyond. This indicates current SP screens fail to detect a number of (late-onset) functional or structural CV toxicities. Additionally, SP uses a significant number of laboratory animals, thereby creating opportunities for a better implementation of the 3Rs. The vision of INSPIRE is to advance and “inspire” SP by exploring new technological capabilities (WP1), addressing emerging CV concerns (WP2) and delivering new validated solutions for CV safety screening (WP3). To this end, INSPIRE unites expertise from academic teams, technology-providers, pharmaceutical companies, regulators and hospitals to create a European training platform for 15 Early Stage Researchers (ESRs). Key innovative aspects of INSPIRE include: i) in vitro humanized cardiomyocytes assays, ii) unparalleled in vivo hardware/software solutions, iii) in silico predictions of haemodynamics, iv) mass spectroscopy imaging of drug exposure, v) exploration of mechanisms of late-onset CV toxicity, as observed in cardio-oncology, and vi) early integration of feedback from industry and regulators. Overall, INSPIRE constitutes a multidisciplinary and intersectoral training programme (WP4) with a balanced combination of hands-on research training, intersectoral secondments, local courses and network-wide events on scientific and transferable skills, enabling future R&I collaborations. Hence, INSPIRE will equip the future generation of SP scientists with a wide range of scientific knowledge and the ability to adapt to a dynamic ever-changing industry.

 Deliverables

List of deliverables.
Start recruitment procedure Other 2020-02-27 15:24:01

Take a look to the deliverables list in detail:  detailed list of INSPIRE deliverables.

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The information about "INSPIRE" are provided by the European Opendata Portal: CORDIS opendata.

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