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INSPIRE SIGNED

INnovation in Safety Pharmacology for Integrated cardiovascular safety assessment to REduce adverse events and late stage drug attrition.

Total Cost €

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EC-Contrib. €

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Partnership

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INSPIRE project word cloud

Explore the words cloud of the INSPIRE project. It provides you a very rough idea of what is the project "INSPIRE" about.

reduce dynamic silico exploring ing pharmacology new local preclinical hands collaborations predictions undesirable animals indicates 3rs structural innovative additionally oncology solutions teams wp3 training inspire software adapt platform changing attrition stage representing sp laboratory hence events academic 15 screens candidates thereby screening hardware vitro hospitals wp1 expertise assays adverse fail transferable providers secondments skills functional drug detect courses scientists off regulators feedback toxicities cardiomyocytes network pharmacodynamic unparalleled haemodynamics technological clinical integration esrs mechanisms cv create validated safety vivo prevalent industry companies constitutes imaging humanized scientific cardiovascular generation combination delivering pharmaceutical uses spectroscopy unites cardio understand mass onset wp2 wp4 vision toxicity vi balanced exploration intersectoral multidisciplinary limitation equip exposure

Project "INSPIRE" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITEIT ANTWERPEN Organization address address: PRINSSTRAAT 13 city: ANTWERPEN postcode: 2000 website: www.ua.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Total cost	4˙021˙968 €
EC max contribution	4˙021˙968 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2019
Funding Scheme	MSCA-ITN-ETN
Starting year	2020
Duration (year-month-day)	from 2020-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITEIT ANTWERPEN UNIVERSITEIT ANTWERPEN Organization address address: PRINSSTRAAT 13 city: ANTWERPEN postcode: 2000 website: www.ua.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ANTWERPEN)	coordinator	768˙960.00
2	THE UNIVERSITY OF NOTTINGHAM THE UNIVERSITY OF NOTTINGHAM Organization address address: University Park city: NOTTINGHAM postcode: NG7 2RD website: www.nottingham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NOTTINGHAM)	participant	606˙345.00
3	NOTOCORD SYSTEMS NOTOCORD SYSTEMS Organization address address: PARC LES GRILLONS 60 ROUTE DE SARTR city: LE PECQ postcode: 78230 LE P website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LE PECQ)	participant	549˙604.00
4	UNIVERSITEIT MAASTRICHT UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	participant	531˙239.00
5	INSTITUT NATIONAL DE RECHERCHE ENINFORMATIQUE ET AUTOMATIQUE INSTITUT NATIONAL DE RECHERCHE ENINFORMATIQUE ET AUTOMATIQUE Organization address address: DOMAINE DE VOLUCEAU ROCQUENCOURT city: LE CHESNAY CEDEX postcode: 78153 website: www.inria.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LE CHESNAY CEDEX)	participant	274˙802.00
6	NCARDIA BV NCARDIA BV Organization address address: GALLILEIWEG 8 city: LEIDEN postcode: 2333 BD website: www.pluriomics.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	265˙619.00
7	WEIZMANN INSTITUTE OF SCIENCE WEIZMANN INSTITUTE OF SCIENCE Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 website: www.weizmann.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (REHOVOT)	participant	263˙500.00
8	UCB BIOPHARMA SRL UCB BIOPHARMA SRL Organization address address: ALLEE DE LA RECHERCHE 60 city: BRUXELLES postcode: 1070 website: www.ucb.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	256˙320.00
9	BOEHRINGER INGELHEIM PHARMA GMBH &CO KG BOEHRINGER INGELHEIM PHARMA GMBH &CO KG Organization address address: BINGER STRASSE 173 city: INGELHEIM postcode: 55218 website: www.boehringer-ingelheim.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (INGELHEIM)	participant	252˙788.00
10	TSE SYSTEMS GMBH TSE SYSTEMS GMBH Organization address address: SIEMENSTRASSE 21 city: BAD HOMBURG VOR DER HOHE postcode: 61352 website: www.tse-systems.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BAD HOMBURG VOR DER HOHE)	participant	252˙788.00

Map

Project objective

New drug candidates often have off-target effects resulting in adverse events, thus representing a major limitation for drug R&D. Safety Pharmacology (SP) aims to detect, understand and reduce undesirable pharmacodynamic effects early-on. Especially, cardiovascular (CV) toxicity is problematic, as it is the most prevalent reason for failure during preclinical development. Moreover, CV toxicity remains a key reason for drug attrition during clinical development and beyond. This indicates current SP screens fail to detect a number of (late-onset) functional or structural CV toxicities. Additionally, SP uses a significant number of laboratory animals, thereby creating opportunities for a better implementation of the 3Rs. The vision of INSPIRE is to advance and “inspire” SP by exploring new technological capabilities (WP1), addressing emerging CV concerns (WP2) and delivering new validated solutions for CV safety screening (WP3). To this end, INSPIRE unites expertise from academic teams, technology-providers, pharmaceutical companies, regulators and hospitals to create a European training platform for 15 Early Stage Researchers (ESRs). Key innovative aspects of INSPIRE include: i) in vitro humanized cardiomyocytes assays, ii) unparalleled in vivo hardware/software solutions, iii) in silico predictions of haemodynamics, iv) mass spectroscopy imaging of drug exposure, v) exploration of mechanisms of late-onset CV toxicity, as observed in cardio-oncology, and vi) early integration of feedback from industry and regulators. Overall, INSPIRE constitutes a multidisciplinary and intersectoral training programme (WP4) with a balanced combination of hands-on research training, intersectoral secondments, local courses and network-wide events on scientific and transferable skills, enabling future R&I collaborations. Hence, INSPIRE will equip the future generation of SP scientists with a wide range of scientific knowledge and the ability to adapt to a dynamic ever-changing industry.

Deliverables

List of deliverables.
Start recruitment procedure	Other	2020-02-27 15:24:01

Take a look to the deliverables list in detail: detailed list of INSPIRE deliverables.

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